Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mia Aaboe Jørgensen"'
Autor:
Marco Carretta, Mads H Andersen, Erika Sutanto-Ward, Inés Lecoq, Evelina Martinenaite, Mia Aaboe Jørgensen, Preeyam Patel, Marion Chapellier, Ayako Pedersen, Shih-Chun Shen, Alex J Muller
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/87906dc5022847b087271844587883ec
Autor:
Marco Donia, Mads Hald Andersen, Lars Grøntved, Daniel Hargbøl Madsen, Inés Lecoq, Evelina Martinenaite, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum, Lucia Lara de la Torre, Simone Kloch Bendtsen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Pancreatic ductal adenocarcinoma (PDAC) is associated with very poor survival, making it the third and fourth leading cause of all cancer-related deaths in the USA and European Union, respectively. The tumor microenvironment (TME) in PDAC
Externí odkaz:
https://doaj.org/article/9b7ffc36e9674c6099fd906a29e40d4b
Autor:
Simone Kloch Bendtsen, Maria Perez-Penco, Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Stine Emilie Weis-Banke, Nicolai Grønne Dahlager Jørgensen, Mia Aaboe Jørgensen, Shamaila Munir Ahmad, Kasper Mølgaard Jensen, Christina Friese, Mia Thorup Lundsager, Astrid Zedlitz Johansen, Marco Carretta, Niels Ødum, Özcan Met, Inge Marie Svane, Daniel Hargbøl Madsen, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Galectin-3 (Gal3) can be expressed by many cells in the tumor microenvironment (TME), including cancer cells, cancer-associated fibroblasts, tumor-associated macrophages, and regulatory T cells (Tregs). In addition to immunosuppression, Gal3 expressi
Externí odkaz:
https://doaj.org/article/4a88182fd3824e069baeb2dcda39bf1d
Autor:
Marco Donia, Mads Hald Andersen, Özcan Met, Lars Grøntved, Daniel Hargbøl Madsen, Inge Marie Svane, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME). Depletion of L-Arg has de
Externí odkaz:
https://doaj.org/article/fff8e87a81a74470aaa2d8cac2b4d443
Autor:
Mads Hald Andersen, Özcan Met, Ayako Wakatsuki Pedersen, Inge Svane, Evelina Martinenaite, Mia Aaboe Jørgensen, Rasmus Erik Johansson Mortensen, Shamaila Munir Ahmad, Stine Emilie Weis-Banke, Morten Orebo Holmström
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/25710882e4574c84a62f97f30e132dc4
Autor:
Stine Emilie Weis-Banke, Mie Linder Hübbe, Morten Orebo Holmström, Mia Aaboe Jørgensen, Simone Kloch Bendtsen, Evelina Martinenaite, Marco Carretta, Inge Marie Svane, Niels Ødum, Ayako Wakatsuki Pedersen, Özcan Met, Daniel Hargbøl Madsen, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2). Here we describe the existence of pro-inflammatory effector T-cells that recognize ARG2 and can directly target
Externí odkaz:
https://doaj.org/article/ea0ac61138cc45ada890530c9c9af0c1
Autor:
Mads Hald Andersen, Vincenzo Bronte, Ayako Wakatsuki Pedersen, Daniel Hargbøll Madsen, Mai-Britt Zocca, Manuela Iezzi, Cristina Frusteri, Francesco De Sanctis, Annalisa Adamo, Marion Chapellier, Katharina Kopp, Evelina Martinenaite, Stine Emilie Weis-Banke, Maria Perez-Penco, Marco Carretta, Mie Linder Hübbe, Stefano Ugel, Mia Aaboe Jørgensen
Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity of ARG1 promotes the formation of an immunosuppressive microenvironment and leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666a35b5cf78d8cf2f4835377ed3e14d
https://doi.org/10.1158/2326-6066.c.6550574
https://doi.org/10.1158/2326-6066.c.6550574
Autor:
Mia Aaboe Jørgensen, Morten Orebo Holmström, Evelina Martinenaite, Caroline Hasselbalch Riley, Hans Carl Hasselbalch, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 7, Iss 9 (2018)
Compelling evidence supports the existence of a profound immune dysregulation in patients with chronic myeloproliferative neoplasms (MPN). Increased Arginase-1 expression has been described in MPN patients and in solid cancers. This increase contribu
Externí odkaz:
https://doaj.org/article/a456711a1bdb48699fe7ea665010c115
Autor:
Shamaila Munir Ahmad, Evelina Martinenaite, Morten Holmström, Mia Aaboe Jørgensen, Özcan Met, Claudia Nastasi, Uffe Klausen, Marco Donia, Lars Møller Pedersen, Lars Munksgaard, Niels Ødum, Anders Woetmann, Inge Marie Svane, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Cell surface molecules of the B7/CD28 family play an important role in T-cell activation and tolerance. The relevance of the PD-1/PD-L1 pathway in cancer has been extensively studied whereas PD-L2 has received less attention. However, recently the ex
Externí odkaz:
https://doaj.org/article/44486a2d00ca4729b4fb08b58c877161
Autor:
Mads Hald Andersen, Özcan Met, Marco Donia, Evelina Martinenaite, Simone Kloch Bendtsen, Mia Aaboe-Jørgensen, Inge Marie Svane, Ayako Wakatsuki Pedersen, Morten Orebo Holmström, Angelos Michail Pavlidis, Stine Emilie Weis-Banke, Rasmus Erik Johansson Mortensen
Publikováno v:
Cell Mol Immunol
Transforming growth factor-beta (TGFβ) is a highly potent immunosuppressive cytokine. Although TGFβ is a tumor suppressor in early/premalignant cancer lesions, the cytokine has several tumor-promoting effects in advanced cancer; abrogation of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3c0673a45bb8d500586bc55720eb1c
https://doi.org/10.1038/s41423-020-00593-5
https://doi.org/10.1038/s41423-020-00593-5