Zobrazeno 1 - 10
of 794
pro vyhledávání: '"MiRNA biogenesis"'
Publikováno v:
Obesities, Vol 4, Iss 2, Pp 93-105 (2024)
Background: Obesity is a critical public health concern with its prevalence growing at an alarming rate worldwide. The Western diet that typically includes high-fat or high-fructose components is one of the leading contributing factors of obesity. Re
Externí odkaz:
https://doaj.org/article/fb7abbd97ee44692b8db878ba8378e28
Publikováno v:
Parasitology, Vol 151, Pp 539-545 (2024)
Small nucleolar RNAs (snoRNAs) are short non-coding RNAs that are abundant in the nucleoli of eukaryotic cells and play a crucial role in various aspects of ribosomal RNA (rRNA) maturation, including modifications such as 2′-O-methylation or pseudo
Externí odkaz:
https://doaj.org/article/b0681da1410d4df0a116f96668b27623
Publikováno v:
Cellular, Molecular and Biomedical Reports, Vol 3, Iss 2, Pp 73-88 (2023)
MicroRNAs (miRNAs) are, small (roughly 19–25 nucleotides in length), conserved, non-coding, single-stranded, and functional RNA molecules with the properties of gene expression regulation through mRNA degradation, translation repression, mRNA deade
Externí odkaz:
https://doaj.org/article/9b0ab61446e44cfbbc281d498164cff0
Akademický článek
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Autor:
Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 165-174 (2022)
Selective targeting of biologically relevant RNAs with small molecules is a long-standing challenge due to the lack of clear understanding of the binding RNA motifs for small molecules. The standard SELEX procedure allows the identification of specif
Externí odkaz:
https://doaj.org/article/4395786fe8e84c3e961dcc08eaac9c5a
Autor:
Marta Soler, Veronica Davalos, Anaís Sánchez‐Castillo, Carlos Mora‐Martinez, Fernando Setién, Edilene Siqueira, Manuel Castro de Moura, Manel Esteller, Sonia Guil
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 648-664 (2022)
Transcribed ultraconserved regions (T‐UCRs) are noncoding RNAs derived from DNA sequences that are entirely conserved across species. Their expression is altered in many tumor types, and, although a role for T‐UCRs as regulators of gene expressio
Externí odkaz:
https://doaj.org/article/ee3cdf516620494bac93ec6af8f9010f
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabo
Externí odkaz:
https://doaj.org/article/1c6b28f5021e45b38d8fd7aec4254bdf
Autor:
Ning Ding, Bailong Zhang
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
In plants, microRNAs (miRNAs) associate with ARGONAUTE (AGO) proteins and act as sequence-specific repressors of target gene expression, at the post-transcriptional level through target transcript cleavage and/or translational inhibition. MiRNAs are
Externí odkaz:
https://doaj.org/article/87df43515b084499b43bcdbce795ed90
Autor:
Yukun Mao, Na Ni, Linjuan Huang, Jiaming Fan, Hao Wang, Fang He, Qing Liu, Deyao Shi, Kai Fu, Mikhail Pakvasa, William Wagstaff, Andrew Blake Tucker, Connie Chen, Russell R. Reid, Rex C. Haydon, Sherwin H. Ho, Michael J. Lee, Tong-Chuan He, Jian Yang, Le Shen, Lin Cai, Hue H. Luu
Publikováno v:
Genes and Diseases, Vol 8, Iss 6, Pp 918-930 (2021)
As multipotent progenitor cells, mesenchymal stem cells (MSCs) can renew themselves and give rise to multiple lineages including osteoblastic, chondrogenic and adipogenic lineages. It's previously shown that BMP9 is the most potent BMP and induces os
Externí odkaz:
https://doaj.org/article/cffd2239ef6243faac16399b43784961
Autor:
Ji Min Park, Jei-Ming Peng, Yu-Shiuan Shen, Chia-Ying Lin, Tung-Wei Hsu, Yen-Hao Su, Hsin-An Chen, Charupong Saengboonmee, Jung-Su Chang, Ching-Feng Chiu, Yan-Shen Shan
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101576- (2022)
Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes. We previously show
Externí odkaz:
https://doaj.org/article/c8e8f6f349d74d5fa97b79586e8f555a