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Persistent detection of varicella-zoster virus DNA in a previously healthy child after severe chickenpox

Autor: Mi-Ran Gent, René A. W. van Lier, Mireille T. M. Vossen, Karla M. C. Peters, Taco W. Kuijpers, Pauline M. E. Wertheim-van Dillen, Koert M. Dolman, Alex van Breda

Publikováno v: Journal of clinical microbiology, 43(11), 5614-5621. American Society for Microbiology

In immunocompetent children with primary varicella-zoster virus (VZV) infection, peak viral loads are detected in peripheral blood near the onset of the vesicular rash. VZV DNA concentrations normally diminish and become undetectable within 3 weeks a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbed9696e7fffec2e44f41c65943e75
https://doi.org/10.1128/jcm.43.11.5614-5621.2005

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Spontaneous outgrowth of EBV-transformed B-cells reflects EBV-specific immunity in vivo; a useful tool in the follow-up of EBV-driven immunoproliferative disorders in allograft recipients

Autor: Taco W. Kuijpers, Debbie van Baarle, Mi-Ran Gent, Pauline M. E. Wertheim-van Dillen, Paul A. Baars, René A. W. van Lier, Jean-Claude Davin, Mireille T. M. Vossen, Marijke T. L. Roos, J. F. L. Weel, Jaap W. Groothoff

Publikováno v: Transplant international, 17(2), 89-96. Wiley-Blackwell

During immunosuppressive medication, Epstein-Barr virus (EBV) infection is associated with a risk of developing posttransplant lymphoproliferative disease (PTLD). The appropriateness of a spontaneous EBV B-cell transformation (SET) assay as a monitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234c1bb5e6b785fa4289b35766fd97f4
https://doi.org/10.1007/s00147-003-0665-4

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Development of virus-specific CD4+ T cells on reexposure to Varicella-Zoster virus

Autor: J. F. L. Weel, Mireille T. M. Vossen, Mi-Ran Gent, René A. W. van Lier, Menno D. de Jong, Taco W. Kuijpers

Publikováno v: The Journal of Infectious Diseases, 190(1), 72-82. Oxford University Press
Journal of infectious diseases, 190(1), 72-82. Oxford University Press

Immunity to childhood diseases is maintained for decades by mechanisms that, at present, are still unclear. We longitudinally studied immune responses in 16 adults exposed to children experiencing varicella (chicken pox). None of the individuals show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0cacb3f638823a173c3c20cd757cee
https://doi.org/10.1086/421277

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Frequencies of Circulating Cytolytic, CD45RA+CD27−, CD8+ T Lymphocytes Depend on Infection with CMV

Autor: J. F. L. Weel, Taco W. Kuijpers, Jean-Claude Davin, Mireille T. M. Vossen, Pauline M. E. Wertheim-van Dillen, Mi-Ran Gent, René A. W. van Lier, Paul A. Baars, Marijke T. L. Roos

Publikováno v: Journal of immunology (Baltimore, Md., 170(8), 4342-4348. American Association of Immunologists

Viral infections may cause serious disease unless the adaptive immune system is able to clear the viral agents through its effector arms. Recent identification and functional characterization of subpopulations of human CD8+ T cells has set the stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343466151ef78ae0a99b789f8f411a00
https://doi.org/10.4049/jimmunol.170.8.4342

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CD27 defines phenotypically and functionally different human NK cell subsets

Autor: Paul A. Baars, Mireille T. M. Vossen, Mourad Matmati, René A. W. van Lier, Taco W. Kuijpers, Mi-Ran Gent, Kirsten M. L. Hertoghs, Jörg Hamann, Georges Leclercq

Publikováno v: Journal of immunology (Baltimore, Md., 180(6), 3739-3745. American Association of Immunologists

The absence of the TNF-receptor family member CD27 marks the stable acquisition of cytolytic effector functions by both CD4+ and CD8+ T cells. We found that the majority of circulating human NK cells was CD27−. These cells were largely CD56dim, con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6067f01262df63bc5a756db3ce292774
https://pubmed.ncbi.nlm.nih.gov/18322179

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Absence of circulating natural killer and primed CD8+ cells in life-threatening varicella

Autor: Menno D. de Jong, Paul A. Baars, Mireille T. M. Vossen, Reneé A.W. van Lier, Taco W. Kuijpers, Maarten H. Biezeveld, Mi-Ran Gent, Ines A. von Rosenstiel

Publikováno v: Journal of infectious diseases, 191(2), 198-206. Oxford University Press
The Journal of Infectious Diseases, 191(2), 198-206. Oxford University Press

Five pediatric patients with no history of immunodeficiency had a life-threatening course of varicella. Strikingly, natural killer (NK) cells were absent from the circulation in all children, and, despite active viral infection, up to 98% of the CD8(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf8914ceeadc16801d0771ca684da66
https://pure.amc.nl/en/publications/absence-of-circulating-natural-killer-and-primed-cd8-cells-in-lifethreatening-varicella(8f19db40-cfa7-4f89-a109-d102179fbc5a).html