Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Mi-Kyoung Seo"'
Autor:
Dong Hwan Ho, Hyejung Kim, Daleum Nam, Mi Kyoung Seo, Sung Woo Park, Dong-Kyu Kim, Ilhong Son
Publikováno v:
NeuroSci, Vol 5, Iss 3, Pp 301-314 (2024)
Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein are involved in the pathogenesis of Parkinson’s disease. The activity of LRRK2 in microglial cells is associated with neuroinflammation, and LRRK2 inhibitors are crucial for alleviating this neu
Externí odkaz:
https://doaj.org/article/e3d6090638ef442b8c176a26ff976812
Autor:
Dawoon E. Jung, Mi-Kyoung Seo, Jung Hyun Jo, Kahee Kim, Chanyang Kim, Hyundeok Kang, Soo Been Park, Hee Seung Lee, Sangwoo Kim, Si Young Song
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Discovery and verification of diagnostic or therapeutic biomarkers for biliary tract cancer (BTC) is challenging owing to the low prevalence of the disease. Here, we identified and investigated the clinical impact of a fusion gene, Pumilio1-
Externí odkaz:
https://doaj.org/article/87b16b76ddf34dcdb212978e21fcc41d
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4324-4336 (2024)
Astrocytes in the brain contribute to various essential functions, including maintenance of the neuronal framework, survival, communication, metabolic processes, and neurotransmitter levels. Leucine-rich repeat kinase 2 (LRRK2) is associated with the
Externí odkaz:
https://doaj.org/article/486c66daa0e54dc99c091cb975b46bdb
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract Gene expression analysis enhances proper cancer subtyping, a better understanding of the molecular characteristics of cancer, and strategies for precision medicine. However, salivary gland cancer (SGC) subtyping remains largely unexplored be
Externí odkaz:
https://doaj.org/article/0e53d96e2525472ea73fa750f3c24330
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Bipolar disorder (BPD) is a severe mental illness characterized by episodes of depression and mania. To investigate the molecular mechanisms underlying the pathophysiology of bipolar disorder, we performed transcriptome studies using RNA-seq
Externí odkaz:
https://doaj.org/article/8a84af76fcd54bfe8cc77884b53fdc13
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Detecting microsatellite instability (MSI) in colorectal cancers (CRCs) is essential because it is the determinant of treatment strategies, including immunotherapy and chemotherapy. Yet, no attempt has been made to exploit transcriptomic pro
Externí odkaz:
https://doaj.org/article/824666ac97524c649a7ccbc739aaef87
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Early life stress (ELS) causes long-lasting changes in gene expression through epigenetic mechanisms. However, little is known about the effects of ELS in adulthood, specifically across different age groups. In this study, the epigenetic mod
Externí odkaz:
https://doaj.org/article/cbb4ceffde4a4676832084b69846e2b8
Autor:
Hyundeok Kang, Mi-Kyoung Seo, BeumJin Park, Sun Och Yoon, Yoon Woo Koh, Dahee Kim, Sangwoo Kim
Publikováno v:
Translational Oncology, Vol 24, Iss , Pp 101496- (2022)
Introduction: Characterizing the tumor microenvironment (TME) and immune landscape of cancer has been a promising step towards discovering new therapeutic biomarkers and guiding precision medicine; however, its application in mucoepidermoid carcinoma
Externí odkaz:
https://doaj.org/article/eaa4b86044f94ee89078c04995445383
Autor:
BeumJin Park, Seok-Jae Heo, Yong Joon Lee, Mi-Kyoung Seo, Jiyun Hong, Eui-Cheol Shin, Inkyung Jung, Sangwoo Kim
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104467- (2022)
Summary: CD8+ T cells recognize and kill tumor cells with HLA-I tumor antigens in early tumorigenesis, the efficiency of which differs according to antigen-recognition coverage, as shown in earlier tumor onset in HLA-I homozygosity. However, the univ
Externí odkaz:
https://doaj.org/article/e091d2774e8941cfa11d6b252a19614d
Autor:
Tae-Min Kim, In Seok Yang, Byung-Joon Seung, Sejoon Lee, Dohyun Kim, Yoo-Jin Ha, Mi-kyoung Seo, Ka-Kyung Kim, Hyun Seok Kim, Jae-Ho Cheong, Jung-Hyang Sur, Hojung Nam, Sangwoo Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Comparison of spontaneous canine cancers and human cancers may illuminate future therapeutic avenues. Here, genomic analyses of these tumors highlights a convergence on PI3K-Akt oncogenic pathways.
Externí odkaz:
https://doaj.org/article/ab1a0a9b68044115ac3ec182334e71fc