Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Mi-Kyoung Kwak"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 3, Pp 501-514 (2024)
Abstract Oxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy production. Cells adapt to varying oxygen levels through intricate response systems. Hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α,
Externí odkaz:
https://doaj.org/article/b333f1bca080400486f61699073b31c1
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102632- (2023)
The acquisition of the cancer stem cell (CSC) properties is often mediated by the surrounding microenvironment, and tumor hypoxia is considered an important factor for CSC phenotype development. High levels of NRF2 (Nuclear Factor Erythroid 2-Like 2;
Externí odkaz:
https://doaj.org/article/f8ffbd77d90c45869ad78b75f5ec007e
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Cancer stem cells (CSCs) exhibit intrinsic therapy/stress resistance, which often cause cancer recurrence after therapy. In this study, we investigated the potential relationship between the cluster of differentiation (CD)-133, a CSC marker of colon
Externí odkaz:
https://doaj.org/article/1f0b1ac739704af0a6d2816c4bb15700
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 246-258 (2018)
Cluster of differentiation 44 (CD44) is the most common cancer stem cell (CSC) marker and high CD44 expression has been associated with anticancer drug resistance, tumor recurrence, and metastasis. In this study, we aimed to investigate the molecular
Externí odkaz:
https://doaj.org/article/aea511e8902f44c3b302955ddd9ab6cc
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
Hypoxia, a common element in the tumor environment, leads to Hypoxia-Inducible Factor-1α (HIF-1α) stabilization to modulate cellular metabolism as an adaptive response. In a previous study, we showed that inhibition of the nuclear factor erythroid
Externí odkaz:
https://doaj.org/article/f8513674e89743ee9725a5ba1f33c7d3
Publikováno v:
Molecules, Vol 19, Iss 8, Pp 12727-12759 (2014)
Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a complex disease due to cardiovascular complications and high morbidity;
Externí odkaz:
https://doaj.org/article/680c4bef0b354b3e8de32b0797eccf22
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150791 (2016)
Pravastatin is a lipid-lowering agent that attenuates atherosclerosis. However, the multifactorial pathogenesis of atherosclerosis requires other drugs with different anti-atherogenic mechanisms. We chose sarpogrelate as an anti-platelet agent and a
Externí odkaz:
https://doaj.org/article/f4d1bba58bb84573a9c915f1aa190487
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153965 (2016)
Chronic kidney disease (CKD) is a major complication of metabolic disorders such as diabetes mellitus, obesity, and hypertension. Comorbidity of these diseases is the factor exacerbating CKD progression. Statins are commonly used in patients with met
Externí odkaz:
https://doaj.org/article/f5da78a36861413da1ef9efe9fd3771f
Autor:
Mi-Kyoung Kwak, Kyeong-Ah Jung
Publikováno v:
Molecules, Vol 15, Iss 10, Pp 7266-7291 (2010)
Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and lipids, and is implicated in various human diseases including cancer, neurodegeneration, inflammatory diseases, and aging. In response to oxidative attack, cell
Externí odkaz:
https://doaj.org/article/4311eb8938b3490a8849a1faa7d439ce
Autor:
Min-Gu Song, In-Geun Ryoo, Hye-Young Choi, Bo-Hyun Choi, Sang-Tae Kim, Tae-Hwe Heo, Joo Young Lee, Pil-Hoon Park, Mi-Kyoung Kwak
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134235 (2015)
Blood monocytes are recruited to injured tissue sites and differentiate into macrophages, which protect against pathogens and repair damaged tissues. Reactive oxygen species (ROS) are known to be an important contributor to monocytes' differentiation
Externí odkaz:
https://doaj.org/article/73da25c6aa3c4b4d8f8e50dc02c343a6