Zobrazeno 1 - 10
of 767
pro vyhledávání: '"Mi-2/NuRD complex"'
Autor:
Yi Qiu, Jiwang Zhang, Bowen Yan, Jennifer Yang, Minyoung Kim, Nicholas Cesari, John Strouboulis, Huacheng Luo, Ross C. Hardison, Suming Huang, Tao Yang
Publikováno v:
Nucleic Acids Research
The activity of hematopoietic factor GATA-1 is modulated through p300/CBP-mediated acetylation and FOG-1 mediated indirect interaction with HDAC1/2 containing NuRD complex. Although GATA-1 acetylation is implicated in GATA-1 activation, the role of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5342f261b241aa41d02b8cbbdb8d55
https://doi.org/10.1093/nar/gkab737
https://doi.org/10.1093/nar/gkab737
DNA methylation atlas and machinery in the developing and regenerating annelid Platynereis dumerilii
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-26 (2021)
BMC Biology
Bmc Biology (1741-7007) (Springer Science and Business Media LLC), 2021-08, Vol. 19, N. 1, P. 148 (26p.)
BMC Biology
Bmc Biology (1741-7007) (Springer Science and Business Media LLC), 2021-08, Vol. 19, N. 1, P. 148 (26p.)
Background Methylation of cytosines in DNA (5mC methylation) is a major epigenetic modification that modulates gene expression and constitutes the basis for mechanisms regulating multiple aspects of embryonic development and cell reprogramming in ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708c699034738165c53106071ef2b912
https://doaj.org/article/c4e5e449aa054d01809fc952d9b6836c
https://doaj.org/article/c4e5e449aa054d01809fc952d9b6836c
Autor:
Xuemei Tan, Ryo Kurita, Dongzhi Li, Liren Wang, Yukio Nakamura, Jiajie Pu, Xiuqin Bao, Dali Li, Yongqiong Liu, Xiaofeng Wei, Xiangmin Xu, Xinhua Zhang, Yuhua Ye, Yunhao Liang, Qianqian Zhang
Publikováno v:
British Journal of Haematology. 193:1220-1227
Reactivation of fetal haemoglobin (HbF) expression is an effective way to treat β-thalassaemia and sickle cell anaemia. In the present study, we identified a novel GATA zinc finger domain-containing protein 2A (GATAD2A) mutation, which contributed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3bae2ede4f6046ba14103556c23ff62
https://doi.org/10.1111/bjh.17511
https://doi.org/10.1111/bjh.17511
Autor:
Simone C. Kleinendorst, Cornelia G. Spruijt, Marijke P. Baltissen, Cathrin Gräwe, Michiel Vermeulen
Publikováno v:
The Febs Journal
FEBS Journal, 288, 10, pp. 3231-3245
FEBS Journal, 288, 3231-3245
FEBS Journal, 288, 10, pp. 3231-3245
FEBS Journal, 288, 3231-3245
Thorough purification and cross‐linking of the NuRD complex from multiple angles led to a high‐density interaction network. The core is formed by MTA‐HDAC and RBBP proteins, to which MBD and GATAD2 proteins dock. The latter proteins associate w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5483dc3ff9bff3b7d189e8ff3ea23f74
https://doi.org/10.1111/febs.15650
https://doi.org/10.1111/febs.15650
Autor:
John W.R. Schwabe, Christopher J. Millard, Christos G. Savva, Timothy J. Ragan, Louise Fairall
Publikováno v:
Nucleic Acids Research
Class I histone deacetylase complexes play essential roles in many nuclear processes. Whilst they contain a common catalytic subunit, they have diverse modes of action determined by associated factors in the distinct complexes. The deacetylase module
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e835dc403e3d543de110c2a0a109236b
https://doi.org/10.1093/nar/gkaa1121
https://doi.org/10.1093/nar/gkaa1121
Akademický článek
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Autor:
Antoni Gañez Zapater, Ann-Kristin Östlund Farrants, Anna Vintermist, Kanwal Tariq, Anna Rolicka, Jaclyn E Quin, Yuan Guo, Fatemeh Sadeghifar, Marie Arsenian-Henriksson
Publikováno v:
The FASEB Journal. 34:10818-10834
Regulation of ribosomal transcription is under tight control from environmental stimuli, and this control involves changes in the chromatin structure. The underlying mechanism of how chromatin changes in response to nutrient and energy supply in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4111708eb3b2c56dafb0ddd06b81ab
https://doi.org/10.1096/fj.202000411r
https://doi.org/10.1096/fj.202000411r
Autor:
Marlene Oeffinger, Tarik Möröy, Charles Joly-Beauparlant, Marina Ayoub, Jean-François Côté, Riyan Chen, Peiman Shooshtarizadeh, Arnaud Droit, Halil Bagci, Kaifee Arman, Anne Helness, Christian Trahan, Jennifer Fraszczak
Publikováno v:
Communications Biology, 4
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Growth factor indepdendent 1 (GFI1) is a SNAG-domain, DNA binding transcriptional repressor which controls myeloid differentiation through molecular mechanisms and co-factors that still remain to be clearly identified. Here we show that GFI1 associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17051cc58718533dcc9d402a4abdca8
https://hdl.handle.net/20.500.11850/519912
https://hdl.handle.net/20.500.11850/519912
Publikováno v:
Doklady Biochemistry and Biophysics. 498:177-179
The Drosophila TTK protein is involved in the processes of cell differentiation and is represented by two isoforms, TTK69 and TTK88, which have a common N-terminal BTB domain and different C-terminal sequences. Earlier, it was shown that TTK69 repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85d0017cc50745bd96584f775c4bb033
https://doi.org/10.1134/s1607672921030042
https://doi.org/10.1134/s1607672921030042
Autor:
Nadia Panera, Cristiano De Stefanis, Anna Pastore, Marco Tartaglia, Ilaria Romito, Rossella Rota, Anna Alisi, Carlo Leonetti, Manlio Vinciguerra, Daniela Gnani, Annalisa Crudele, Emmanuel de Billy, Stefano Levi Mortera, Manuela Porru, Valeria Marzano, Clara Balsano, Maria Rita Braghini, Luca Pompili, Marco Scarsella, Lorenza Putignani, Silvia Pomella, Adrian Libenzio Conti
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)
Background Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumours worldwide. Sorafenib (SOR) is one of the most effective single-drug systemic therapy against advanced HCC, but the identification of novel combination re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2c91afd89edfb39b5133ca41ce696f
https://doi.org/10.1186/s13046-021-02154-8
https://doi.org/10.1186/s13046-021-02154-8