Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mi Sik Shin"'
Autor:
Banda Narsaiah, Woul Seong Park, Sung-Soo Kim, Seung Kyu Kang, Jin Hee Ahn, Myung Ae Bae, Duck-Hyung Lee, Mi Sik Shin, Mi Ae Jun, Ki Young Kim, Hyae Gyeong Cheon, Sang Dal Rhee, Kwon Sung-Wook
Publikováno v:
Journal of Fluorine Chemistry. 130:1001-1010
A series of triazepane derivatives such as (R)-3-amino-1-(1,2,5-triazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-ones (7, 13a–p) and (R)-3-amino-1-(1,2,5-triazepan-5-yl)-4-(2,4,5-trifluorophenyl)butan-1-ones (17a–e) was synthesized and evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d201984eea6ce40ac98516047f119bb2
https://doi.org/10.1016/j.jfluchem.2009.08.001
https://doi.org/10.1016/j.jfluchem.2009.08.001
Autor:
Sang Dal Rhee, Hyae Gyeong Cheon, Nam Sook Kang, Mi Sik Shin, Seung Kyu Kang, Jie Oh Lee, Jin Hee Ahn, Myung Ae Bae, Ki Young Kim, Woul Seong Park, Sung Gyu Kim, Sun Young Kim, Duck-Hyung Lee, Sung-Soo Kim, Sang Kwon Sohn, Mi Ae Jun, Kwang Rok Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6525-6529
Compounds with homopiperazine skeleton are designed to find a potent DPP-IV inhibitor without inhibiting CYP. Thus a series of β-aminoacyl-containing homopiperazine derivatives was synthesized and evaluated. Compounds with acid moiety were found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73b0a194e15f643e7ac446ecb05b937
https://doi.org/10.1016/j.bmcl.2008.10.076
https://doi.org/10.1016/j.bmcl.2008.10.076
Autor:
Sung-Soo Kim, Ki Young Kim, Woul Seong Park, Seung Kyu Kang, Mi Ae Jun, Jin Hee Ahn, Sang Dal Rhee, Mi Sik Shin, Duck-Hyung Lee, Hyae Gyeong Cheon
Publikováno v:
Bulletin of the Korean Chemical Society. 29:2129-2134
Department of Chemistry, Sogang University, Seoul 121-742, KoreaReceived August 3, 2008In continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of β-aminoacyl-containing 5-, 6- and 7- membered cyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c2347921e1bf26cc9babacd3e891a05
https://doi.org/10.5012/bkcs.2008.29.11.2129
https://doi.org/10.5012/bkcs.2008.29.11.2129
Autor:
Sun Ho Jung, Mi Ae Jun, Jie Oh Lee, Nam Sook Kang, Sung Gyu Kim, Sang-Kwon Sohn, Sun Young Kim, Seung Kyu Kang, Mi Sik Shin, Hyae Gyeong Cheon, Mi Sun Jin, Jin Hee Ahn, Sang Dal Rhee, Sung-Soo Kim, Kwang Rok Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2622-2628
Inhibitors of dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes. A series of β-aminoacyl-containing cyclic hydrazine derivatives were synthesized and evaluated as DPP-IV inhibitors. One member of this se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5960fdc092ee5864aae6ea0590013f
https://doi.org/10.1016/j.bmcl.2007.01.111
https://doi.org/10.1016/j.bmcl.2007.01.111
Autor:
Seung Kyu Kang, Jin Hee Ahn, Sang Dal Rhee, Seung Jun Kim, Won Hoon Jung, Hyae Gyeong Cheon, Sung Soo Kim, Kwang Rok Kim, Sung Don Yang, Joo Rang Woo, Jeong Hyung Lee, Mi Sik Shin, Sun Ho Jung
Publikováno v:
Journal of Medicinal Chemistry. 49:4781-4784
Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d750e2fa427326e408dfefc93eeb9753
https://doi.org/10.1021/jm060389m
https://doi.org/10.1021/jm060389m
Autor:
Min-Sun Kim, Seung Kyu Kang, Jin Hee Ahn, Myung Ae Bae, Dong Hyun Song, Nam Sook Kang, Sang Dal Rhee, Mi Ae Jun, Kwang Rok Kim, Stephen Schneider, Woul Seong Park, Jie Oh Lee, Sung-Soo Kim, Peter Silinski, Ki-Young Kim, Sung-Eun Yoo, Mi Sik Shin
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(5)
A series of β-aminoacyl containing thiazolidine derivatives was synthesized and evaluated for their ability to inhibit DPP-IV. Several thiazolidine derivatives with an acid moiety were found to be potent DPP-IV inhibitors. Among them, compound 2da i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21365a403350f93b33baf46f389cc48
https://pubmed.ncbi.nlm.nih.gov/21306895
https://pubmed.ncbi.nlm.nih.gov/21306895
Autor:
Ki Young Kim, Woul Seong Park, Seung Kyu Kang, Sung-Soo Kim, Jin Hee Ahn, Mi Ae Jun, Sang Dal Rhee, Mi Sik Shin, Duck-Hyung Lee, Hyae Gyeong Cheon
Publikováno v:
ChemInform. 40
Department of Chemistry, Sogang University, Seoul 121-742, KoreaReceived August 3, 2008In continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of β-aminoacyl-containing 5-, 6- and 7- membered cyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91c74211efa6f4579c3203582b6cc15
https://doi.org/10.1002/chin.200912176
https://doi.org/10.1002/chin.200912176
Autor:
Mi Sik Shin, Jae Mok Lee, Sung-Soo Kim, Jeong Hyung Lee, Hyemin Kim, Sun Ho Jung, Jin Ah Kim, Sung Dae Park, Se Hoan Kim, Hyae Gyeong Cheon, Kwang Rok Kim, Sang Dal Rhee, Seung Kyu Kang, Jin Hee Ahn
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(18)
A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARgamma. The best PPARgamma agonist in this series was 9h, which showed an EC(50) value of 15 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d2efc9d69d1ff2f00b44fe07b67d19
https://pubmed.ncbi.nlm.nih.gov/17624777
https://pubmed.ncbi.nlm.nih.gov/17624777