Výsledky vyhledávání - "Mi Kwon, Son"

Akademický článek

ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a

Autor: Kyung Hee Jung, Mi Kwon Son, Hong Hua Yan, Zhenghuan Fang, Juyoung Kim, Soo Jung Kim, Jung Hee Park, Ji Eun Lee, Young‐Chan Yoon, Myeong Seong Seo, Beom Seok Han, Soyeon Ko, Young Ju Suh, Joo Han Lim, Don‐Haeng Lee, Ziqiang Teo, Jonathan Wei Kiat Wee, Nguan Soon Tan, Soon‐Sun Hong

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 8, Pp 1-19 (2020)

Abstract Pancreatitis is the inflammation of the pancreas. However, little is known about the genes associated with pancreatitis severity. Our microarray analysis of pancreatic tissues from mild and severe acute pancreatitis mice models identified an

Externí odkaz: https://doaj.org/article/9ddcdb3fea6f4d339aa61f04fa2c5ca5

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Combination Therapy of the Active KRAS-Targeting Antibody inRas37 and a PI3K Inhibitor in Pancreatic Cancer

Autor: Min Gyu Woo, Yong Sung Kim, Mi Kwon Son, Seung-Min Shin, Zhenghuan Fang, Kyung Hee Jung, Soon-Sun Hong, Young-Chan Yoon, Hong Hua Yan, Ji Eun Lee, Yeo Wool Kang, Jung Hee Park

Publikováno v: Biomolecules & Therapeutics. 30:274-283

KRAS activating mutations, which are present in more than 90% of pancreatic cancers, drive tumor dependency on the RAS/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Therefore, combined targeting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda310720b90dedc65c717389b364882
https://doi.org/10.4062/biomolther.2021.145

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ANGPTL4 accelerates KRASG12D-Induced acinar to ductal metaplasia and pancreatic carcinogenesis

Autor: Jung Hee Park, Juyoung Kim, Mi Kwon Son, Soo Jung Kim, Hong Hua Yan, Ji Eun Lee, Zhenghuan Fang, Kyung Hee Jung, Soon-Sun Hong, Ju Han Lim

Publikováno v: Cancer Letters. 519:185-198

Oncogenic KRASG12D induces neoplastic transformation of pancreatic acinar cells through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN), and drives pancreatic ductal adenocarcinoma (PDAC). Angiopoietin-like 4 (ANGPT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55c37d8bfb5ad2b07c73db348c985d00
https://doi.org/10.1016/j.canlet.2021.07.036

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Synergistic radiosensitizing effect of BR101801, a specific DNA-dependent protein kinase inhibitor, in various human solid cancer cells and xenografts

Autor: Jae Hee, Lee, Byeongwook, Jeon, Mijeong, Park, Jimin, Ha, Soo Jung, Kim, Mi Kwon, Son, Seungho, Wang, Joo Han, Lee, Youn Kyoung, Jeong

Publikováno v: Am J Cancer Res

DNA-dependent protein kinase (DNA-PK), an essential component of the non-homologous end-joining (NHEJ) repair pathway, plays an important role in DNA damage repair (DDR). Therefore, DNA-PK inhibition is a promising approach for overcoming radiotherap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88aef2ddfc72bb1bee3748cb6b1e3325
https://pubmed.ncbi.nlm.nih.gov/34873471

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KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer

Autor: Yong Sung Kim, Kyung Hee Jung, Soon-Sun Hong, Yeo Wool Kang, Seung-Min Shin, Min Ji Cheon, Soo Jung Kim, Min Gyu Woo, Mi Kwon Son, Boreum Han, Hong Hua Yan, Jung Hee Park, Zhenghuan Fang, Joo Han Lim, Ji Eun Lee

Publikováno v: Cancer Letters. 438:174-186

Pancreatic cancer exhibits an oncogenic KRAS mutation rate of ∼90%. Despite research and drug development efforts focused on KRAS, no targeted therapy has been clinically approved for the treatment of pancreatic cancer with KRAS mutation. Also, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a77d2679d9642277cd1ae9950109fe8
https://doi.org/10.1016/j.canlet.2018.09.013

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Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape

Autor: Min Gyu Woo, Soo Jung Kim, Ji Eun Lee, Zhenghuan Fang, Yong Sung Kim, Seung-Min Shin, Myung Sung Seo, Min Ji Cheon, Kyung Hee Jung, Soon-Sun Hong, Mi Kwon Son, Jung Hee Park, Yeo Wool Kang, Young-Chan Yoon, Hong Hua Yan, Joo Han Lim, Boreum Han, Ji-Sun Kim

Publikováno v: Cancer letters. 507

KRAS mutation is associated with the progression and growth of pancreatic cancer and contributes to chemo-resistance, which poses a significant clinical challenge in pancreatic cancer. Here, we developed a RT22-ep59 antibody (Ab) that directly target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277d479dc1aa3831b57f3f584100c086
https://pubmed.ncbi.nlm.nih.gov/33744388

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ANGPTL 4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a

Autor: Ji Eun Lee, Young-Chan Yoon, Zhenghuan Fang, Don Haeng Lee, Kyung Hee Jung, Soon-Sun Hong, Nguan Soon Tan, Soo Jung Kim, Juyoung Kim, Ziqiang Teo, Jung Hee Park, Joo Han Lim, Jonathan Wei Kiat Wee, Soyeon Ko, Myeong Seong Seo, Beom Seok Han, Young Ju Suh, Mi Kwon Son, Hong Hua Yan

Publikováno v: Publons
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)

Pancreatitis is the inflammation of the pancreas. However, little is known about the genes associated with pancreatitis severity. Our microarray analysis of pancreatic tissues from mild and severe acute pancreatitis mice models identified angiopoieti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf06c5e6ba893d1b11ccf12480c1427d
https://doi.org/10.15252/emmm.201911222

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Radiosensitization of the PI3K inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer

Autor: Hong Hua Yan, Kyung Hee Jung, Soon-Sun Hong, Mi Kwon Son, Zhenghuan Fang, Soo Jung Kim, Boreum Han, Yeo Wool Kang, Jung Hee Park, Juyoung Kim, Joo Han Lim, Ji Eun Lee

Publikováno v: Oncotarget

Activation of PI3K/AKT pathway occurs frequently in tumors and is correlated with radioresistance. The PI3K/AKT pathway can be an important target for improvement of radiotherapy. Although adding of chemotherapy to radiation therapy regimen enhances

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006f582cdbeb6051fc959d0e4812a106
https://doi.org/10.18632/oncotarget.22850

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