Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mhd Rami Al Shweiki"'
Autor:
Patrick Oeckl, Heiko Graf, Mhd Rami Al Shweiki, Petra Steinacker, Carlos Schönfeldt-Lecuona, Markus Otto, Albert C. Ludolph
Publikováno v:
Journal of psychiatric research 144, 54-58 (2021). doi:10.1016/j.jpsychires.2021.09.012
Neuroinflammation has been connected to the pathophysiology of major depressive disorder (MDD) and neurochemical biomarkers of glial pathology could aid the diagnosis and might support patient stratification and monitoring in clinical trials. Our stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad2b05e3e36019c5d6ccdf127045f75
https://doi.org/10.1016/j.jpsychires.2021.09.012
https://doi.org/10.1016/j.jpsychires.2021.09.012
Autor:
Nerea Gómez de San José, Julie Goossens, Mhd Rami Al Shweiki, Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Karin M. Danzer, Heiko Graf, Carlos Schönfeldt-Lecuona, Olivia Belbin, Alberto Lleó, Eugeen Vanmechelen, Markus Otto
Publikováno v:
Journal of psychiatric research 156, 390-397 (2022). doi:10.1016/j.jpsychires.2022.10.010
Psychiatric disorders are widely underreported diseases, especially in their early stages. So far, there is no fluid biomarker to confirm the diagnosis of these disorders. Proteomics data suggest the synaptic protein glutamate receptor 4 (GluR4), par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ea92486f0a08b93c9befbf0d9e741b
https://pubmed.ncbi.nlm.nih.gov/36323141
https://pubmed.ncbi.nlm.nih.gov/36323141
Autor:
Mhd Rami Al Shweiki, Johannes Kornhuber, Janine Diehl-Schmid, John C. van Swieten, Markus Otto, Sarah Anderl-Straub, Jochen H. Weishaupt, Martin Lauer, Peggy Barschke, Alexander E Volk, Petra Steinacker, Adrian Danek, Albert C. Ludolph, Patrick Oeckl, Emma L. van der Ende, G. Bernhard Landwehrmeyer, Holger Jahn, Patrick Weydt, Klaus Fassbender, Matthias L. Schroeter, Johannes Prudlo
Publikováno v:
Journal of Neurology Neurosurgery and Psychiatry, 91(5), 503-511. BMJ Publishing Group
Journal of neurology, neurosurgery, and psychiatry 91(5), 503-511 (2020). doi:10.1136/jnnp-2019-322476
Journal of neurology, neurosurgery, and psychiatry 91(5), 503-511 (2020). doi:10.1136/jnnp-2019-322476
ObjectivesThe hexanucleotide repeat expansion in the C9orf72 gene is the most common mutation associated with amyotrophic lateral sclerosis (C9-ALS) and frontotemporal dementia (C9-FTD). Until now, it is unknown which factors define whether C9orf72 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e39a866b365bc1e3f8509103f2b49aa
https://doi.org/10.1136/jnnp-2019-322476
https://doi.org/10.1136/jnnp-2019-322476
Autor:
Samir Abu-Rumeileh, Peggy Barschke, Patrick Oeckl, Simone Baiardi, Angela Mammana, Andrea Mastrangelo, Mhd Rami Al Shweiki, Petra Steinacker, Anna Ladogana, Sabina Capellari, Markus Otto, Piero Parchi
Publikováno v:
International journal of molecular sciences 23(4), 2051 (2022). doi:10.3390/ijms23042051
Proenkephalin (PENK) and prodynorphin (PDYN) are endogenous opioid peptides mainly produced in the striatum and, to a lesser extent, in the cerebral cortex. Dysregulated metabolism and altered cerebrospinal fluid (CSF) levels of PENK and PDYN have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f0f169ec3d2bec56ffd9935f874906
Autor:
Wolfgang Hoehenwarter, Domenika Thieme, Mona Bassal, Petra Majovsky, Mhd Rami Al Shweiki, Mohammad Abukhalaf, Steffen Neumann, Naheed Tabassum, Ali Hmedat, Jörg Ziegler, Carsten Proksch, Mohamed Ayash, Tobias Herr, Justin Lee
Publikováno v:
Molecular plant. 13(12)
Proteome remodeling is a fundamental adaptive response and proteins in complex and functionally related proteins are often co-expressed. Using a deep sampling strategy we define Arabidopsis thaliana tissue core proteomes at around 10,000 proteins per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13faf4b08dadee84d2d2c14cd28f330d
https://pubmed.ncbi.nlm.nih.gov/33007468
https://pubmed.ncbi.nlm.nih.gov/33007468
Autor:
Bastian Hengerer, Mhd Rami Al Shweiki, Cornelia Dorner-Ciossek, Markus Otto, Petra Steinacker, Carlos Schönfeldt-Lecuona, Peggy Barschke, Patrick Oeckl
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
Major depressive disorder (MDD) is a leading cause of morbidity with a lifetime prevalence of 10%. There is increasing evidence suggesting synaptic dysfunction and impaired integrity of certain brain circuits in MDD. Here we investigate the cerebrosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602ea63b96f3271c4c215e6b7a330a09
https://doi.org/10.1038/s41398-020-0825-7
https://doi.org/10.1038/s41398-020-0825-7
Autor:
Markus Otto, Sarah Anderl-Straub, Georg Bernhard Landwehrmeyer, Peggy Barschke, Adrian Pachollek, Steffen Halbgebauer, Petra Steinacker, Patrick Oeckl, Mhd Rami Al Shweiki, Albert C. Ludolph, Jan Lewerenz
Publikováno v:
Movement disorders 36(2), 492-497 (2021). doi:10.1002/mds.28300
RESULTS Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by a selective loss of striatal medium spiny projection neurons (MSNs). Prodynorphin (PDYN) is enriched in a subpopulation of striatal MSNs. Postmortem brains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb3e3789da08dededa375cbe4bcf6e8
https://pubmed.ncbi.nlm.nih.gov/33599006
https://pubmed.ncbi.nlm.nih.gov/33599006
Autor:
Mona Bassal, Mhd Rami Al Shweiki, Joerg Ziegler, Domenika Thieme, Mohammad Abukhalaf, Petra Majovsky, Wolfgang Hoehenwarter, Mohamed Ayash, Tobias Herr, Carsten Proksch, Steffen Neumann, Ali Hmedat
Proteome remodeling is a fundamental adaptive response and proteins in complex and functionally related proteins are often co-expressed. Using a deep sampling strategy we define Arabidopsis thaliana tissue core proteomes at around 10,000 proteins per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bcf730579bbab1cd12721d07650953
Autor:
Bastian Hengerer, Markus Otto, Mhd Rami Al Shweiki, Petra Steinacker, Carlos Schönfeldt-Lecuona, Patrick Oeckl
Publikováno v:
Expert Review of Proteomics. 14:499-514
Major Depressive Disorder (MDD) is the leading cause of global disability, and an increasing body of literature suggests different cerebrospinal fluid (CSF) proteins as biomarkers of MDD. The aim of this review is to summarize the suggested CSF bioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5da35233db5a7b633de761d401e7cf0
https://doi.org/10.1080/14789450.2017.1336435
https://doi.org/10.1080/14789450.2017.1336435
Autor:
Peggy, Barschke, Patrick, Oeckl, Petra, Steinacker, Mhd Rami, Al Shweiki, Jochen H, Weishaupt, G Bernhard, Landwehrmeyer, Sarah, Anderl-Straub, Patrick, Weydt, Janine, Diehl-Schmid, Adrian, Danek, Johannes, Kornhuber, Matthias L, Schroeter, Johannes, Prudlo, Holger, Jahn, Klaus, Fassbender, Martin, Lauer, Emma Louise, van der Ende, John Cornelis, van Swieten, Alexander E, Volk, Albert C, Ludolph, Markus, Otto, Jens, Wiltfang
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry. 91(5)
The hexanucleotide repeat expansion in theWe compared the CSF proteome of 16 C9-ALS and 8 C9-FTD patients and 11 asymptomaticIn total, 2095 CSF proteins were identified and 236 proteins were significantly different in C9-ALS versus C9-FTD including n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f15ff952f08d0af5232f255ff95b68e3
https://pubmed.ncbi.nlm.nih.gov/32132225
https://pubmed.ncbi.nlm.nih.gov/32132225