Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Mhairi Nimick"'
Autor:
Hannah Palmer, Mhairi Nimick, Aloran Mazumder, Sebastien Taurin, Zohaib Rana, Rhonda J. Rosengren
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 853 (2022)
Androgen receptor (AR)-castrate-resistant prostate cancer (CRPC) is an aggressive form of prostate cancer that does not have clinically approved targeted treatment options. To this end, the cytotoxic potential of raloxifene and the synthetic curcumin
Externí odkaz:
https://doaj.org/article/af40c00f01894d87b20e909f23539b10
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other lipids released from cells at the same time. An increasing volume of anecdotal reports and interest in the pla
Externí odkaz:
https://doaj.org/article/0deab7b24cc44707bc5f970d36018079
Publikováno v:
Biology, Vol 10, Iss 12, p 1326 (2021)
Folivore marsupials, such as brushtail possum (Trichosurus Vulpecula) and koala (Phascolarctos cinereus), can metabolise higher levels of dietary terpenes, such as cineole, that are toxic to eutherian mammals. While the highly efficient drug metaboli
Externí odkaz:
https://doaj.org/article/b66688e6aa8b45f69af43c9793cbb1b2
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract ALK positive non-small cell lung cancer is highly responsive to ALK inhibitors such as crizotinib, but drug resistance typically develops within a year of treatment. In this study we investigated whether IGF-1R is an independent druggable ta
Externí odkaz:
https://doaj.org/article/398999e043dc426f9106b6eb7c119b5d
Autor:
Nensi Shrestha, Zabeen Lateef, Orleans Martey, Abigail R. Bland, Mhairi Nimick, Rhonda Rosengren, John C. Ashton
Publikováno v:
F1000Research, Vol 8 (2019)
Lung cancer drug development requires screening in animal models. We aimed to develop orthotopic models of human non-small lung cancer using A549 and H3122 cells delivered by tail vein injection. This procedure has been used previously for a mouse lu
Externí odkaz:
https://doaj.org/article/ea9d4aefef0546e585750238b98f57ec
Autor:
Tony Ferrar, Delphine Chamousset, Veerle De Wever, Mhairi Nimick, Jens Andersen, Laura Trinkle-Mulcahy, Greg B. G. Moorhead
Publikováno v:
Biology Open, Vol 1, Iss 2, Pp 128-139 (2012)
Summary The promiscuous activity of protein phosphatase one (PP1) is controlled in the cell by associated proteins termed regulatory or targeting subunits. Using biochemical and proteomic approaches we demonstrate that the autosomal recessive nonsynd
Externí odkaz:
https://doaj.org/article/238a250b0f1a4e108c0dd18b2d2c5dc1
Autor:
Veerle De Wever, David C Lloyd, Isha Nasa, Mhairi Nimick, Laura Trinkle-Mulcahy, Robert Gourlay, Nick Morrice, Greg B G Moorhead
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39510 (2012)
Metazoan mitosis requires remodelling of sub-cellular structures to ensure proper division of cellular and genetic material. Faults often lead to genomic instability, cell cycle arrests and disease onset. These key structural changes are under tight
Externí odkaz:
https://doaj.org/article/b674daa69e1f4f0c8d8b023cea388afa
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9424
The potential to improve the effectiveness and efficiency of potential oestrogen-based oral contraceptives (fertility control) for possums was investigated by comparing the inhibitory potential of hepatic CYP3A and UGT2B catalytic activity using a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c3c7e0c4fe6a044dd35989c207e4fb
Autor:
David B. Finlay, Warwick Mackie, Hunter D.J. Webb, Lucy R. Thomsen, Mhairi Nimick, Rhonda J. Rosengren, Julie A. Marusich, Michelle Glass, Jenny L. Wiley
Publikováno v:
Pharmacology Biochemistry and Behavior. 223:173530
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb3a6f7935e785cd2bb37c12f7386765
https://doi.org/10.1016/j.pbb.2023.173530
https://doi.org/10.1016/j.pbb.2023.173530
Autor:
Sebastien Taurin, Khaled Greish, Vignesh Sundararajan, Orleans N. K. Martey, Mhairi Nimick, Rhonda J. Rosengren
Publikováno v:
International Journal of Nanomedicine
Orleans Martey,1 Mhairi Nimick,1 Sebastien Taurin,1 Vignesh Sundararajan,1 Khaled Greish,2 Rhonda J Rosengren1 1Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; 2Department of Molecular Medicine, College of Medici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450b57210ebae99f572dc0918cd2961c
https://doi.org/10.2147/ijn.s148908
https://doi.org/10.2147/ijn.s148908