Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Mhairi J. Maxwell"'
Autor:
Yue You, Xueyi Dong, Yong Kiat Wee, Mhairi J. Maxwell, Monther Alhamdoosh, Gordon K. Smyth, Peter F. Hickey, Matthew E. Ritchie, Charity W. Law
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Group heteroscedasticity is commonly observed in pseudo-bulk single-cell RNA-seq datasets and its presence can hamper the detection of differentially expressed genes. Since most bulk RNA-seq methods assume equal group variances, we introduce
Externí odkaz:
https://doaj.org/article/d10773884bdb4c46881828200216a0c4
Autor:
Yue You, Xueyi Dong, Yong Kiat Wee, Mhairi J. Maxwell, Monther Alhamdoosh, Gordon K. Smyth, Peter F. Hickey, Matthew E. Ritchie, Charity W. Law
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/069db538e8c34bdfb20f76f929315fd0
Autor:
Devy Deliyanti, Dean M. Talia, Tong Zhu, Mhairi J. Maxwell, Alex Agrotis, Jack R. Jerome, Emily M. Hargreaves, Steven Gerondakis, Margaret L. Hibbs, Fabienne Mackay, Jennifer L. Wilkinson-Berka
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The local immune responses in the eye are attenuated to preserve sight. Surprisingly, Deliyanti et al. show that regulatory T cells (Tregs) take an active role in protecting the eye from neovascularization in oxygen-induced retinopathy, and that inte
Externí odkaz:
https://doaj.org/article/50f3675a81e5466f9c5075205f5d2ecb
Autor:
Yue You, Xueyi Dong, Yong Kiat Wee, Mhairi J Maxwell, Monther Alhamdoosh, Gordon K Smyth, Peter F Hickey, Matthew E Ritchie, Charity W Law
Group heteroscedasticity is commonly observed in pseudo-bulk single-cell RNA-seq datasets and when not modelled appro-priately, its presence can hamper the detection of differentially expressed genes. Most bulk RNA-seq methods assume equal group vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5509008b16cb382dad91d45a4990521b
https://doi.org/10.1101/2022.09.12.507511
https://doi.org/10.1101/2022.09.12.507511
Autor:
Nicole Kucera, Jiulia Satiaputra, Janice .H.C. Plani-Lam, Cindy Le, Evan Ingley, Mhairi J Maxwell, Susan Wu, Cathy Quilici, Alison Louw, Edward Bastow, Margaret L. Hibbs, Neli Slavova-Azmanova
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d98f3670a7c8cc20de76b255b16b70f
https://doi.org/10.1096/fasebj.2021.35.s1.00181
https://doi.org/10.1096/fasebj.2021.35.s1.00181
Autor:
Dean M Talia, Devy Deliyanti, Alex Agrotis, Tong Zhu, Emily M Hargreaves, S Gerondakis, Jack R Jerome, Jennifer L. Wilkinson-Berka, Mhairi J Maxwell, Fabienne Mackay, Margaret L. Hibbs
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Neovascular retinopathies are major causes of vision loss; yet treatments to prevent the condition are inadequate. The role of regulatory T cells in neovascular retinopathy is unknown. Here we show that in retinopathy regulatory T cells are transient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bf95bf7959f0474402123cbeb8cdf2
http://link.springer.com/article/10.1038/s41467-017-00751-w
http://link.springer.com/article/10.1038/s41467-017-00751-w
Autor:
Nicole Kucera, Jiulia Satiaputra, Evan Ingley, Mhairi J Maxwell, Cathy Quilici, Alison Louw, Cindy Le, Neli Slavova-Azmanova, Susan Wu, Margaret L. Hibbs, Janice .H.C. Plani-Lam, Edward Bastow
Publikováno v:
Blood. 136:24-24
Erythroleukemia (M6 subtype of Acute Myeloid Leukaemia) is uncommon but has a poor prognosis, with reports of successful differentiation therapy using erythropoietin (Epo). Signaling through the Epo-receptor, which involves JAK2 and Lyn tyrosine kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bc02a8ded850e6c18641c741a74b230
https://doi.org/10.1182/blood-2020-140187
https://doi.org/10.1182/blood-2020-140187
Autor:
Daniel P Steinfort, S Passey, Gary P. Anderson, Maverick Lau, Natalie A. Sims, Michelle J. Hansen, Margaret L. Hibbs, Louis Irving, Cassandra M.N. Castelino, Mhairi J Maxwell, Evelyn Tsantikos, Narelle E. McGregor
Chronic obstructive pulmonary disease (COPD) is an incurable inflammatory lung disease that afflicts millions of people worldwide, and it is the fourth leading cause of death. Systemic comorbidities affecting the heart, skeletal muscle, bone, and met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3f5605dd42da148b24a490011926f7
https://europepmc.org/articles/PMC5983324/
https://europepmc.org/articles/PMC5983324/
Publikováno v:
International Journal of Clinical Rheumatology. 9:519-535
The Lyn tyrosine kinase plays a key regulatory role in the immune system that was first highlighted by the phenotype of Lyn-/- mice. These animals develop an autoimmune disease similar to the autoimmune disorder systemic lupus erythematosus. Deregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c975fc453a176226087f84038183e70f
https://doi.org/10.2217/ijr.14.44
https://doi.org/10.2217/ijr.14.44
Autor:
Pablo A. Silveira, Robyn Maree Slattery, Alexandra I. Ziegler, Margaret L. Hibbs, Magdalena Plebanski, Jessica Stolp, J. F. A. P. Miller, Mhairi J Maxwell, Pere Santamaria, Abhirup Jayasimhan, Melanie Le Page, Haoyao Guo
Publikováno v:
Diabetologia. 56:2659-2668
Type 1 diabetes is characterised by early peri-islet insulitis and insulin autoantibodies, followed by invasive insulitis and beta cell destruction. The immunological events that precipitate invasive insulitis are not well understood. We tested the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c078b70d7251fbcdaef055442d09a10
https://doi.org/10.1007/s00125-013-3038-2
https://doi.org/10.1007/s00125-013-3038-2