Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mhairi C. Towler"'
Autor:
Silvie Timmers, Johan de Vogel-van den Bosch, Mhairi C. Towler, Gert Schaart, Esther Moonen-Kornips, Ronald P. Mensink, Matthijs K. Hesselink, D. Grahame Hardie, Patrick Schrauwen
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 2, Pp 352-359 (2010)
Skeletal muscle triglyceride accumulation is associated with insulin resistance in obesity. Recently, it has been suggested that α lipoic acid (ALA) improves insulin sensitivity by lowering triglyceride accumulation in nonadipose tissues via activat
Externí odkaz:
https://doaj.org/article/6e3efee7a0be4dd087e92f53254c2be4
Autor:
Andrew Philp, Matthew G MacKenzie, Micah Y Belew, Mhairi C Towler, Alan Corstorphine, Angela Papalamprou, D Grahame Hardie, Keith Baar
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77200 (2013)
Performing exercise in a glycogen depleted state increases skeletal muscle lipid utilization and the transcription of genes regulating mitochondrial β-oxidation. Potential candidates for glycogen-mediated metabolic adaptation are the peroxisome prol
Externí odkaz:
https://doaj.org/article/e5d7fa7b55c24790b3f6d96a1ece2973
Publikováno v:
Molecular Biology of the Cell
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
instname
11 pages, 7 figures, 1 table. -- PMID: 20534808 [PubMed]PMCID: PMC2912345Free PMC Article
Lafora progressive myoclonus epilepsy is a fatal neurodegenerative disorder caused by defects in the function of at least two proteins: laforin, a dual-spe
Lafora progressive myoclonus epilepsy is a fatal neurodegenerative disorder caused by defects in the function of at least two proteins: laforin, a dual-spe
Autor:
Kirsteen J. W. Mustard, Keith Baar, John A. Babraj, Calum Sutherland, Henning Wackerhage, Daniel J. Cuthbertson, Michael J. Rennie, Graeme P. Leese, Michaela Thomason-Hughes, D. Grahame Hardie, Mhairi C. Towler, Kevin A. Green
Publikováno v:
Diabetes. 56:2078-2084
Activation of AMP-activated protein kinase (AMPK) in rodent muscle by exercise, metformin, 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR), and adiponectin increases glucose uptake. The aim of this study was to determine whether AICAR
Autor:
David A. Pan, David Carling, Benoit Viollet, D. Grahame Hardie, Pascual Sanz, Mhairi C. Towler, Rosa Viana
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Copyright © by The American Society for Biochemistry and Molecular Biology
Mammalian AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status. AMPK is a heterotrimer of three diffe
Mammalian AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status. AMPK is a heterotrimer of three diffe
Autor:
Mhairi C. Towler, D. Grahame Hardie
Publikováno v:
Circulation Research. 100:328-341
The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with AT
Publikováno v:
Traffic. 5:129-139
Skeletal muscle tissue is made up of highly organized multinuclear cells. The internal organization of the muscle cell is dictated by the necessary regular arrangement of repeated units within the protein myofibrils that mediate muscle contraction. S
Publikováno v:
Molecular Exercise Physiology ISBN: 9780203132142
In this chapter we aim to answer questions such as ‘why and how do we adapt to exercise?’ We begin by highlighting limitations to the classical view of supercompensation in exercise training, before introducing the signal transduction hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f38b20999da027bafc0c57397a6e46ef
https://doi.org/10.4324/9780203132142-11
https://doi.org/10.4324/9780203132142-11
Publikováno v:
Experimental Cell Research. 259:167-179
The endoplasmic reticulum and Golgi apparatus play key roles in regulating the folding, assembly, and transport of newly synthesized proteins along the secretory pathway. We find that the divalent cation manganese disrupts the Golgi apparatus and end
Autor:
Mhairi C. Towler, John M. Lucocq, John James, Sreenivasan Ponnambalam, D.M. Hickinson, Stephen R. James, S. Clough, C.P. Downes
Publikováno v:
University of St Andrews CRIS
The eukaryotic trans-Golgi network (TGN) is a key site for the formation of transport vesicles destined for different intracellular compartments [1]. A key marker for the mammalian TGN is TGN38/46 [2]. This integral membrane glycoprotein cycles betwe