Výsledky vyhledávání - "Mhairi A. Skinner"

V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway

Autor: Dennis A. Ausiello, Andrés Hurtado-Lorenzo, Shaliha Bechoua, Alan G. Wildeman, Mhairi A. Skinner, Sylvain G. Bourgoin, Jaafar El Annan, Dennis Brown, Vladimir Marshansky, James E. Casanova, Ge-Hong Sun-Wada, Masamitsu Futai

Publikováno v: Nature Cell Biology. 8:124-136

The recruitment of the small GTPase Arf6 and ARNO from cytosol to endosomal membranes is driven by V-ATPase-dependent intra-endosomal acidification. The molecular mechanism that mediates this pH-sensitive recruitment and its role are unknown. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e06daec513ea2a11d12158cef66d0a1
https://doi.org/10.1038/ncb1348

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Expression of the Vacuolar H+-ATPase 16-kDa Subunit Results in the Triton X-100-insoluble Aggregation of β1 Integrin and Reduction of Its Cell Surface Expression

Autor: Michael Pierce, Intaek Lee, Mhairi A. Skinner, Hua-Bei Guo, Avinash Sujan

Publikováno v: Journal of Biological Chemistry. 279:53007-53014

Vacuolar H(+)-ATPase functions as a vacuolar proton pump and is responsible for acidification of intracellular compartments such as the endoplasmic reticulum, Golgi, lysosomes, and endosomes. Previous reports have demonstrated that a 16-kDa subunit (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdfda6c66bb170dcec27dc451cdacc2
https://doi.org/10.1074/jbc.m405717200

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The 16 kDa subunit of vacuolar H+-ATPase is a novel sarcoglycan-interacting protein

Autor: Mhairi A. Skinner, Qian-Chun Yu, Weixing Shi, Alan G. Wildeman, Yiu-mo Michael Chan, Jiwei Chen

Publikováno v: Biochimica et biophysica acta. 1772(5)

The sarcoglycan complex in muscle consists of alpha-, beta-, gamma- and delta-sarcoglycan and is part of the larger dystrophin-glycoprotein complex (DGC), which is essential for maintaining muscle membrane integrity. Mutations in any of the four sarc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d35c10c21cf27a8667e8d1bcab29bc
https://pubmed.ncbi.nlm.nih.gov/17382524

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V‐ATPase Interacts with ARNO and Arf6 in Early Endosomes and Regulates the Protein Degradative Pathway

Autor: Dennis Brown, Alan G. Wildeman, James E. Casanova, Masamitsu Futai, Vladimir Marshansky, Jaafar El Annan, Andrés Hurtado-Lorenzo, Ge-Hong Sun-Wada, Sylvain G. Bourgoin, Dennis A. Ausiello, Mhairi A. Skinner

Publikováno v: The FASEB Journal. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bbab2687139a9615adf4693d69a9d56
https://doi.org/10.1096/fasebj.20.5.a1225

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Dynamic life and death interactions between Mycobacterium smegmatis and J774 macrophages

Autor: Monica Hagedorn, Leila Staali, Maximiliano G. Gutierrez, Mhairi A. Skinner, Mark P. Kuehnel, Elsa Anes, Alan G. Wildeman, Isabelle Maridonneau-Parini, Gareth Griffiths, Holger Kress, Luísa Jordão, Stefanos A. Kalamidas, Pascale Peyron

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cellular Microbiology, 8(6), 939-960. Wiley-Blackwell

After internalization into macrophages non-pathogenic mycobacteria are killed within phagosomes. Pathogenic mycobacteria can block phagosome maturation and grow inside phagosomes but under some conditions can also be killed by macrophages. Killing me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b202d67e6de1e393dda79a65046bc10

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Suppression of tumor-related glycosylation of cell surface receptors by the 16-kDa membrane subunit of vacuolar H+-ATPase

Autor: Alan G. Wildeman, Mhairi A. Skinner

Publikováno v: The Journal of biological chemistry. 276(51)

The glycosylation of integrins and other cell surface receptors is altered in many transformed cells. Notably, an increase in the number of beta1,6-branched N-linked oligosaccharides correlates strongly with invasive growth of cells. An ectopic expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8489742afae7f7ef1a87c71102fdafd0
https://pubmed.ncbi.nlm.nih.gov/11604389

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beta(1) integrin binds the 16-kDa subunit of vacuolar H(+)-ATPase at a site important for human papillomavirus E5 and platelet-derived growth factor signaling

Autor: Alan G. Wildeman, Mhairi A. Skinner

Publikováno v: The Journal of biological chemistry. 274(33)

Integrins mediate adhesive interactions between cells and the extracellular matrix, and play a role in cell migration, proliferation, differentiation, cytoskeletal organization, and signal transduction. We have identified an interaction between the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84603bf5ac2d10a709c28b9bd44d07e3
https://pubmed.ncbi.nlm.nih.gov/10438481

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Abstract LB-130: The NCI-Nature Pathway Interaction Database: A cell signaling resource

Autor: Mhairi A. Skinner, Carl F. Schaefer, Kenneth H. Buetow, Kira Anthony, Jeffrey Buchoff, Matthew Day

Publikováno v: Cancer Research. 70:LB-130

The NCI-Nature Pathway Interaction Database (PID, http://pid.nci.nih.gov) is a freely available collection of professionally curated and expert-reviewed signaling and regulatory pathways composed of human molecular interactions, signaling events and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8e2a205b4c4225ca997724edc2c0679
https://doi.org/10.1158/1538-7445.am10-lb-130

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