V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway

Autor: Dennis A. Ausiello, Andrés Hurtado-Lorenzo, Shaliha Bechoua, Alan G. Wildeman, Mhairi A. Skinner, Sylvain G. Bourgoin, Jaafar El Annan, Dennis Brown, Vladimir Marshansky, James E. Casanova, Ge-Hong Sun-Wada, Masamitsu Futai

Publikováno v: Nature Cell Biology. 8:124-136

The recruitment of the small GTPase Arf6 and ARNO from cytosol to endosomal membranes is driven by V-ATPase-dependent intra-endosomal acidification. The molecular mechanism that mediates this pH-sensitive recruitment and its role are unknown. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e06daec513ea2a11d12158cef66d0a1
https://doi.org/10.1038/ncb1348

The 16 kDa subunit of vacuolar H+-ATPase is a novel sarcoglycan-interacting protein

Autor: Mhairi A. Skinner, Qian-Chun Yu, Weixing Shi, Alan G. Wildeman, Yiu-mo Michael Chan, Jiwei Chen

Publikováno v: Biochimica et biophysica acta. 1772(5)

The sarcoglycan complex in muscle consists of alpha-, beta-, gamma- and delta-sarcoglycan and is part of the larger dystrophin-glycoprotein complex (DGC), which is essential for maintaining muscle membrane integrity. Mutations in any of the four sarc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d35c10c21cf27a8667e8d1bcab29bc
https://pubmed.ncbi.nlm.nih.gov/17382524

Dynamic life and death interactions between Mycobacterium smegmatis and J774 macrophages

Autor: Monica Hagedorn, Leila Staali, Maximiliano G. Gutierrez, Mhairi A. Skinner, Mark P. Kuehnel, Elsa Anes, Alan G. Wildeman, Isabelle Maridonneau-Parini, Gareth Griffiths, Holger Kress, Luísa Jordão, Stefanos A. Kalamidas, Pascale Peyron

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cellular Microbiology, 8(6), 939-960. Wiley-Blackwell

After internalization into macrophages non-pathogenic mycobacteria are killed within phagosomes. Pathogenic mycobacteria can block phagosome maturation and grow inside phagosomes but under some conditions can also be killed by macrophages. Killing me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b202d67e6de1e393dda79a65046bc10

beta(1) integrin binds the 16-kDa subunit of vacuolar H(+)-ATPase at a site important for human papillomavirus E5 and platelet-derived growth factor signaling

Autor: Alan G. Wildeman, Mhairi A. Skinner

Publikováno v: The Journal of biological chemistry. 274(33)

Integrins mediate adhesive interactions between cells and the extracellular matrix, and play a role in cell migration, proliferation, differentiation, cytoskeletal organization, and signal transduction. We have identified an interaction between the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84603bf5ac2d10a709c28b9bd44d07e3
https://pubmed.ncbi.nlm.nih.gov/10438481

Dynamic life and death interactions between Mycobacterium smegmatis and J774 macrophages.

Autor: Anes, Elsa¹, Peyron, Pascale^2,3, Staali, Leila³, Jordao, Luisa¹, Gutierrez, Maximiliano G.⁴, Kress, Holger³, Hagedorn, Monica³, Maridonneau-Parini, Isabelle², Skinner, Mhairi A.⁵, Wildeman, Alan G.⁵, Kalamidas, Stefanos A.⁶, Kuehnel, Mark³, Griffiths, Gareth³ griffiths@embl.de

Publikováno v: Cellular Microbiology. Jun2006, Vol. 8 Issue 6, p939-960. 22p. 1 Diagram, 1 Chart, 6 Graphs.