Zobrazeno 1 - 10
of 2 440
pro vyhledávání: '"Mfn2"'
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background The interplay between intrauterine and early postnatal environments has been associated with an increased risk of cardiovascular diseases in adulthood, including pulmonary arterial hypertension (PAH). While emerging evidence highl
Externí odkaz:
https://doaj.org/article/597633c4f1074ea6b90323f874bbf1ce
Autor:
Wang Yu, Lun Jie, Zhang Yuying, Yu Mengchao, Liu Xingqian, Guo Jing, Zhang Hongwei, Qiu Wensheng, Fang Jing
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1498-1508 (2024)
MicroRNAs (miRNAs) are implicated in the development of cancers and may serve as potential targets for therapy. However, the functions and underlying mechanisms of miRNAs in cancers are not well understood. This work aims to study the role of miR-373
Externí odkaz:
https://doaj.org/article/1a46f5b453084d70adb7aca4066ed5f9
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionBladder cancer (BCa) is a common malignancy in the urinary tract. It has high recurrence rates and often requires microscopic examination, which presents significant challenges in clinical treatment. Previous research has shown that circu
Externí odkaz:
https://doaj.org/article/e52beea7415c495099a2cdced5b831b6
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionMajor Depression (MD) is a common mental disorder. In East Asian ancestry, the association, causality, and shared genetic basis between blood-based biomarkers and MD remain unclear.MethodsWe investigated the relationships between blood-ba
Externí odkaz:
https://doaj.org/article/0d45b59049144ae998a2af6c94934fde
Publikováno v:
Iraqi Journal of Pharmaceutical Sciences, Vol 33, Iss 2 (2024)
Doxorubicin (DOX) has been used to treat malignant diseases for over 40 years. The main constraint to its clinical application is dose-dependent cardiotoxicity which is regarded as a major matter of concern that limits its medical usefulness. Mitocho
Externí odkaz:
https://doaj.org/article/0e5ed7829da24102b8d4716e9b1cff8a
Publikováno v:
BMC Pediatrics, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Charcot-Marie-Tooth disease (CMT) is a group of single-gene hereditary diseases of peripheral nerve with high clinical variability and genetic heterogeneity. The typical clinical manifestations include progressive muscle weakness
Externí odkaz:
https://doaj.org/article/7fc473ee92e543898fa219242b0dfb4c
Autor:
Xiuhua Liao, Suqin Zhu, Shumin Qiu, Hua Cao, Wenwen Jiang, Huiling Xu, Yan Sun, Beihong Zheng
Publikováno v:
Endocrine Connections, Vol 13, Iss 1, Pp 1-10 (2023)
This study aimed to investigate the role of mitochondrial-related protein Mfn2 in polycystic ovary syndrome (PCOS) and its impact on oocyte development. The pathological features of PCOS model mice were confirmed by hematoxylin–eosin staining and i
Externí odkaz:
https://doaj.org/article/92851381d67043e697edb2e8e902343d
Autor:
Claudia Alberti, Federica Rizzo, Alessia Anastasia, Giacomo Comi, Stefania Corti, Elena Abati
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106467- (2024)
Mutations in the gene encoding MFN2 have been identified as associated with Charcot–Marie–Tooth disease type 2A (CMT2A), a neurological disorder characterized by a broad clinical phenotype involving the entire nervous system. MFN2, a dynamin-like
Externí odkaz:
https://doaj.org/article/61d3992231b24faf865ff203534e3424
Autor:
Lang Hu, Daishi Tang, Bingchao Qi, Dong Guo, Ying Wang, Jing Geng, Xiaoliang Zhang, Liqiang Song, Pan Chang, Wensheng Chen, Feng Fu, Yan Li
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract The heart primarily derives its energy through lipid oxidation. In cardiomyocytes, lipids are stored in lipid droplets (LDs) and are utilized in mitochondria, although the structural and functional connections between these two organelles re
Externí odkaz:
https://doaj.org/article/2c1916f2a1e44655bc311fc1f6f9b97e
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Neutrophils depend heavily on glycolysis for energy production under normal conditions. In contrast, neutrophils require energy supplied by mitochondrial oxidative phosphorylation (OXPHOS) during chemotaxis. However, the mechanism
Externí odkaz:
https://doaj.org/article/58a953e3095749dcbb88cc5c25bc5c89