Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mezmur D. Belew"'
/SummaryIn many organisms, mRNA transcription must be globally repressed in germline precursor cells during specification for them to maintain a germline fate. In C. elegans, germline precursor cells are known as the P lineage, and it is the PIE-1 pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d366d82d9fbe7d4a9c44c8ba70bb19f5
https://doi.org/10.1101/2022.08.30.505898
https://doi.org/10.1101/2022.08.30.505898
/SummaryWhile it has been appreciated for decades that prophase-arrested oocytes are transcriptionally silenced on a global level, the molecular pathways that promote silencing have remained elusive. Previous work inC. eleganshas shown that both topo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::148afe8e83cf7e6b236adeb4c2789c1e
https://doi.org/10.1101/2022.08.28.505591
https://doi.org/10.1101/2022.08.28.505591
Publikováno v:
The Journal of cell biology. 220(9)
While much is known about how transcription is controlled at individual genes, comparatively little is known about how cells regulate gene expression on a genome-wide level. Here, we identify a molecular pathway in the C. elegans germline that contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d4ae7a44ca9956fb5f5abb3bab1397
https://pubmed.ncbi.nlm.nih.gov/34383014
https://pubmed.ncbi.nlm.nih.gov/34383014
Autor:
Zachary Walsh, Philip R. Brauer, Engda G. Hagos, Brian Chernak, William M. Rosencrans, Nadia Houerbi, Mezmur D. Belew, Andrew Blum, Angel Trazo, Changchang Liu, Anna Olson
Publikováno v:
European journal of cell biology. 99(1)
Kruppel-like factor 4 (Human Protein: KLF4; Human Gene: Klf4; Murine Protein: KLF4; Murine Gene: Klf4) is a zinc finger-containing transcription factor with diverse regulatory functions. Mouse embryonic fibroblasts (MEFs) lacking Klf4 exhibit genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4efb520e2e70bee29dc2e9b1c552902
https://pubmed.ncbi.nlm.nih.gov/31839365
https://pubmed.ncbi.nlm.nih.gov/31839365
Publikováno v:
Developmental Cell. 46:302-315.e5
Summary In Caenorhabditis elegans, the primordial germ cells Z2 and Z3 are born during early embryogenesis and then held in a transcriptionally quiescent state where the genome is highly compacted. When hatched L1s feed, the germline genome decompact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141e8bb3d24d96d86415d9ef639d1cf6
https://doi.org/10.1016/j.devcel.2018.07.002
https://doi.org/10.1016/j.devcel.2018.07.002