Altered functional connectivity in preterm neonates with intraventricular hemorrhage assessed using functional near-infrared spectroscopy

Autor: Lilian M. N. Kebaya, Lingkai Tang, Talal Altamimi, Alexandra Kowalczyk, Melab Musabi, Sriya Roychaudhuri, Homa Vahidi, Paige Meyerink, Sandrine de Ribaupierre, Soume Bhattacharya, Leandro Tristao Abi Ramia de Moraes, Keith St. Lawrence, Emma G. Duerden

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Intraventricular hemorrhage (IVH) is a common neurological injury following very preterm birth. Resting-state functional connectivity (RSFC) using functional magnetic resonance imaging (fMRI) is associated with injury severity; yet, fMRI is

Externí odkaz: https://doaj.org/article/d678ebc3f31f43e6ac292bb7df12aac5

Early postnatal administration of an AAV9 gene therapy is safe and efficacious in CLN3 disease

Autor: Tyler B. Johnson, Jon J. Brudvig, Shibi Likhite, Melissa A. Pratt, Katherine A. White, Jacob T. Cain, Clarissa D. Booth, Derek J. Timm, Samantha S. Davis, Brandon Meyerink, Ricardo Pineda, Cassandra Dennys-Rivers, Brian K. Kaspar, Kathrin Meyer, Jill M. Weimer

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

CLN3 disease, caused by biallelic mutations in the CLN3 gene, is a rare pediatric neurodegenerative disease that has no cure or disease modifying treatment. The development of effective treatments has been hindered by a lack of etiological knowledge,

Externí odkaz: https://doaj.org/article/cb379df157064165b746745383d34428

Altered functional connectivity in preterm neonates with intraventricular hemorrhage assessed using functional near-infrared spectroscopy.

Autor: Kebaya LMN; Neonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Paediatrics, Division of Neonatal-Perinatal Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Tang L; Biomedical Engineering, Faculty of Engineering, Western University, London, ON, Canada., Altamimi T; Neonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Kowalczyk A; Neonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Musabi M; Neonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Roychaudhuri S; Neonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Vahidi H; Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Meyerink P; Neonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., de Ribaupierre S; Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Biomedical Engineering, Faculty of Engineering, Western University, London, ON, Canada.; Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Bhattacharya S; Neonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., de Moraes LTAR; Medical Imaging, London Health Sciences Centre, Western University, London, ON, Canada., Lawrence KS; Biomedical Engineering, Faculty of Engineering, Western University, London, ON, Canada.; Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Duerden EG; Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. eduerden@uwo.ca.; Biomedical Engineering, Faculty of Engineering, Western University, London, ON, Canada. eduerden@uwo.ca.; Applied Psychology, Faculty of Education, Western University, 1137 Western Road, London, ON, N6G 1G7, Canada. eduerden@uwo.ca.

Publikováno v: Scientific reports [Sci Rep] 2024 Sep 27; Vol. 14 (1), pp. 22300. Date of Electronic Publication: 2024 Sep 27.

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