A COVID-19 vaccine candidate composed of SARS-CoV-2 RBD dimer and Neisseria meningitidis outer membrane vesicles

Autor: Darielys Santana-Mederos, Rocmira Perez-Nicado, Yanet Climent, Laura Rodriguez, Belinda Sanchez Ramirez, Sonia Perez-Rodriguez, Meybi Rodriguez, Claudia Labrada, Tays Hernandez, Marianniz Diaz, Ivette Orosa, Ubel Ramirez, Reynaldo Oliva, Raine Garrido, Felix Cardoso, Mario Landys, Roselyn Martinez, Humberto Gonzalez, Tamara Hernandez, Rolando Ochoa-Azze, Jose L. Perez, Juliet Enriquez, Nibaldo Gonzalez, Yenicet Infante, Luis A. Espinosa, Yassel Ramos, Luis Javier González, Carmen Valenzuela, Ana Victoria Casadesus, Briandy Fernandez, Gertrudis Rojas, Beatriz Pérez-Massón, Yaima Tundidor, Ernesto Bermudez, Claudia A. Plasencia, Tammy Boggiano, Eduardo Ojito, Fabrizio Chiodo, Sonsire Fernandez, Françoise Paquet, Cheng Fang, Guang-Wu Chen, Daniel G. Rivera, Yury Valdes-Balbin, Dagmar Garcia-Rivera, Vicente Verez Bencomo

Publikováno v: RSC Chemical Biology
RSC Chemical Biology, Royal Society of Chemistry, In press, ⟨10.1039/D1CB00200G⟩
Santana-Mederos, D, Perez-Nicado, R, Climent, Y, Rodriguez, L, Ramirez, B S, Perez-Rodriguez, S, Rodriguez, M, Labrada, C, Hernandez, T, Diaz, M, Orosa, I, Ramirez, U, Oliva, R, Garrido, R, Cardoso, F, Landys, M, Martinez, R, Gonzalez, H, Hernandez, T, Ochoa-Azze, R, Perez, J L, Enriquez, J, Gonzalez, N, Infante, Y, Espinosa, L A, Ramos, Y, González, L J, Valenzuela, C, Casadesus, A V, Fernandez, B, Rojas, G, Pérez-Massón, B, Tundidor, Y, Bermudez, E, Plasencia, C A, Boggiano, T, Ojito, E, Chiodo, F, Fernandez, S, Garcia-Rivera, D, Fang, C, Chen, G-W, Rivera, D G, Valdes-Balbin, Y, Garcia-Rivera, D & Verez Bencomo, V 2022, ' A COVID-19 vaccine candidate composed of the SARS-CoV-2 RBD dimer and : Neisseria meningitidis outer membrane vesicles ', RSC Chemical Biology, vol. 3, no. 2, pp. 242-249 . https://doi.org/10.1039/d1cb00200g
RSC Chemical Biology, 3(2), 242-249. Royal Society of Chemistry

SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain (RBD) with the host's cellular receptor. Vaccines seek to block this interaction by eliciting neutralizing antibodies, most of which

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https://hal.archives-ouvertes.fr/hal-03519898