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Derisking the Polymorph Landscape: The Complex Polymorphism of Mexiletine Hydrochlorid

Autor: James F. McCabe, Matthew T. Mulvee, Jonathan W. Steed, Stefanie Freitag-Pohl, Andrei S. Batsanov, David J. Berry, Katharina Edkins, Sten O. Nilsson Lill, Dmitry S. Yufit, Michael R. Probert, Jessica L. Andrews, David C. Apperley

Publikováno v: Andrews, J L, Nielsson Lill, S O, Freitag-Pohl, S, Apperley, D, Yufit, D S, Batsanov, A S, Mulvee, M T, Edkins, K, McCabe, J F, Berry, D J, Probert, M R & Steed, J W 2021, ' Derisking the Polymorph Landscape: The Complex Polymorphism of Mexiletine Hydrochlorid ', Crystal Growth & Design, vol. 21, no. 12, pp. 7150–7167 . https://doi.org/10.1021/acs.cgd.1c01009
Crystal Growth & Design, 2021, Vol.21(12), pp.7150-7167 [Peer Reviewed Journal]

This work presents an updated solid-form discovery approach to the polymorphism of the antiarrhythmic drug mexiletine hydrochloride, in which experimental and computational techniques are combined to provide a rigorous characterization of the solid-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c36f25318e5c2cfd9e2f75ac2e2372
https://pure.manchester.ac.uk/ws/files/205532675/Mexiletine_CGD_ref_revision_final.docx

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Study protocol for the MEXiletine hydrochloride administration trial: a placebo-controlled, randomised, double-blind, multicentre, crossover study of its efficacy and safety in spinal and bulbar muscular atrophy (MEXPRESS)

Autor: Tomohiko Nakamura, Daisuke Ito, Fumie Kinoshita, Akihiro Hirakawa, Yumiko Kobayashi, Masahisa Katsuno, Yasuhiro Hijikata, Atsushi Hashizume, Tomonori Inagaki, Shinichiro Yamada, Masahiro Nakatochi

Publikováno v: BMJ Open. 8:e023041

IntroductionSpinal and bulbar muscular atrophy (SBMA) is a slowly progressive neuromuscular disease. Cold exposure often leads to worsening of motor symptoms including paresis. Although mexiletine hydrochloride administration has been shown to be eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d095dde9e1fbbdcffaf4068b5d5f2142
https://doi.org/10.1136/bmjopen-2018-023041

Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution

Autor: Constantinos K. Zacharis, Pantelis G. Rigas, Paraskevas D. Tzanavaras

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 48:1254-1260

The first automated method for the determination of mexiletine hydrochloride - an antiarrhythmic agent - is reported. The method is based on the reaction of the analyte with o-phthalaldehyde (OPA) in the presence of sulfite in basic medium using a se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9da9d3251ad85629bd83603dda97fd4
https://doi.org/10.1016/j.jpba.2008.09.017