Amino acid primed mTOR activity is essential for heart regeneration.

Autor: Miklas JW; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Levy S; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA., Hofsteen P; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Pathology, University of Washington, Seattle, WA 98109, USA.; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA., Mex DI; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA., Clark E; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Muster J; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.; Department of Pharmacology, University of Washington, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Robitaille AM; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Pharmacology, University of Washington, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Sivaram G; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA., Abell L; Department of Pathology, University of Washington, Seattle, WA 98109, USA.; Mitochondria and Metabolism Center, University of Washington, Seattle, WA 98109, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA., Goodson JM; Department of Pathology, University of Washington, Seattle, WA 98109, USA., Pranoto I; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA., Madan A; Covance Genomics Laboratory, Redmond, WA 98052, USA., Chin MT; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Pathology, University of Washington, Seattle, WA 98109, USA.; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA.; Department of Medicine/Cardiology, University of Washington, Seattle, WA 98109, USA., Tian R; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA.; Mitochondria and Metabolism Center, University of Washington, Seattle, WA 98109, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA., Murry CE; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.; Department of Pathology, University of Washington, Seattle, WA 98109, USA.; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA.; Department of Medicine/Cardiology, University of Washington, Seattle, WA 98109, USA., Moon RT; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Pharmacology, University of Washington, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Wang Y; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA 98195, USA., Ruohola-Baker H; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA.

Publikováno v: IScience [iScience] 2021 Dec 06; Vol. 25 (1), pp. 103574. Date of Electronic Publication: 2021 Dec 06 (Print Publication: 2022).