Zobrazeno 1 - 10
of 5 953
pro vyhledávání: '"Mevalonate pathway"'
Autor:
Alejandro Durán, Maximiliano Venegas, Salvador Barahona, Dionisia Sepúlveda, Marcelo Baeza, Víctor Cifuentes, Jennifer Alcaíno
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-13 (2024)
Abstract The yeast Xanthophyllomyces dendrorhous synthesizes astaxanthin, a high-value carotenoid with biotechnological relevance in the nutraceutical and aquaculture industries. However, enhancing carotenoid production through strain engineering rem
Externí odkaz:
https://doaj.org/article/aa3455e8fc3b455289b1a5e2dc1c7d88
Autor:
Hulya Karaca, Murat Kaya, Handan Açelya Kapkac, Serkan Levent, Yusuf Ozkay, Secil Deniz Ozan, Jens Nielsen, Anastasia Krivoruchko
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Background Metabolic engineering enables the sustainable and cost-efficient production of complex chemicals. Efficient production of terpenes in Saccharomyces cerevisiae can be achieved by recruiting an intermediate of the mevalonate pathway
Externí odkaz:
https://doaj.org/article/a295840edbce4ef7bdd81a762e3bc912
Publikováno v:
FEBS Open Bio, Vol 14, Iss 8, Pp 1320-1339 (2024)
Mevalonate kinase is a key regulator of the mevalonate pathway, subject to feedback inhibition by the downstream metabolite farnesyl pyrophosphate. In this study, we validated the hypothesis that monophosphonate compounds mimicking farnesyl pyrophosp
Externí odkaz:
https://doaj.org/article/f3b39f8cb51148878b197019f34d72a3
Autor:
Azka Khan Durrani, Momina Khalid, Awais Raza, Izza Faiz ul Rasool, Waseem Khalid, Muhammad Nadeem Akhtar, Ammar Ahmad Khan, Zunair Abdullah, Babirye Khadijah
Publikováno v:
CyTA - Journal of Food, Vol 22, Iss 1 (2024)
ABSTRACTβ-sitosterol is waxy substance, white in color distributed in a variety of natural plant sources cereals, pulses, legumes, vegetables, fruits, and herbs. Several clinical and preclinical investigations indicate that β-sitosterol has a wide
Externí odkaz:
https://doaj.org/article/2ab97f09d84d4afe9d0875cb4992cdb7
Akademický článek
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Autor:
Diandra Zipinotti dos Santos, Mohamad Elbaz, Emily Branchard, Wiebke Schormann, Carla E. Brown, Autumn R. Meek, Vincent C.O. Njar, Robert J. Hamilton, Mark A. Reed, David W. Andrews, Linda Z. Penn
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116934- (2024)
There is an urgent need to provide immediate and effective options for the treatment of prostate cancer (PCa) to prevent progression to lethal castration-resistant PCa (CRPC). The mevalonate (MVA) pathway is dysregulated in PCa, and statin drugs comm
Externí odkaz:
https://doaj.org/article/699af22ca7604478ae0e47c46ba49ef6
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
Membrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids, glycosylphosphatidylino
Externí odkaz:
https://doaj.org/article/e9c23f10bcfb4e15863c2d0a21c58d48
Autor:
Yasuhiro Kato, Masaru Matsumoto, Natsuki Takano, Mariko Hirao, Kuniko Matsuda, Takehiro Tozuka, Naomi Onda, Shinji Nakamichi, Susumu Takeuchi, Akihiko Miyanaga, Rintaro Noro, Akihiko Gemma, Masahiro Seike
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Introduction A neurotrophic tropomyosin receptor kinase (NTRK)‐tyrosine kinase inhibitor (TKI) has shown dramatic efficacy against malignant tumors harboring an NTRK fusion gene. However, almost all tumors eventually acquire resistance to
Externí odkaz:
https://doaj.org/article/7e17ba81b3294778a9a44409ba4acb39
Autor:
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre PA Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus G Manz, Steffen Boettcher
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 445-474 (2024)
Abstract TP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic option f
Externí odkaz:
https://doaj.org/article/3995291a6c424aeaadea031a81b64f56
Publikováno v:
Cancer Reports, Vol 7, Iss 5, Pp n/a-n/a (2024)
Abstract Background Statins, frequently prescribed medications, work by inhibiting the rate‐limiting enzyme HMG‐CoA reductase (HMGCR) in the mevalonate pathway to reduce cholesterol levels. Due to their multifaceted benefits, statins are being ad
Externí odkaz:
https://doaj.org/article/33a0cbdfe84b4227bd4c874c3678eb3d