Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross‐over study

Autor: Ida Kuhlmann, Amanda Nøddebo Nyrup, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Troels Korshøj Bergmann, Per Damkier, Flemming Nielsen, Kurt Højlund, Kim Brøsen

Publikováno v: Clinical and Translational Science, Vol 14, Iss 6, Pp 2408-2419 (2021)

Abstract The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intraven

Externí odkaz: https://doaj.org/article/b40ce672adc646a18fbe9434186c5a6f

No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients

Autor: Ida Kuhlmann, Kim Brøsen, Kenn Dornonville de la Cour, Troels K Bergmann, Mette Marie Hougaard Christensen, Tore Bjerregaard Stage, Stine Thorhauge Zwisler, Per Damkier, Anders Gadegaard Jensen, Rasmus Hjelmar Petersen, Flemming Nielsen, Morten Overgaard

Publikováno v: Kuhlmann, I, Petersen, R H, Overgaard, M, Dornonville de la Cour, K, Zwisler, S, Stage, T B, Christensen, M M H, Bergmann, T K, Damkier, P, Jensen, A G, Nielsen, F & Brøsen, K 2022, ' No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients ', Basic & Clinical Pharmacology & Toxicology, vol. 130, no. 1, pp. 93-102 . https://doi.org/10.1111/bcpt.13667

We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d00b400355041daf5d65f43d1ea4765
https://doi.org/10.1111/bcpt.13667

Glaukom opstået under behandling med sertralin

Autor: morten rix hansen, Mette Marie Hougaard Christensen

Publikováno v: Hansen, M R & Christensen, M M 2021, ' Glaukom opstået under behandling med sertralin ', Maanedsskrift for Almen Praksis, bind 98, nr. 8, s. 572-575 .
University of Southern Denmark

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a865d23dfb93df38747c4f36ac79b4c3
https://portal.findresearcher.sdu.dk/da/publications/53db04c9-e505-45a3-a1e1-08987162ac7a

Using a limited sampling strategy to investigate the interindividual pharmacokinetic variability in metformin:A large prospective trial

Autor: Kim Brøsen, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Sidsel Arnspang Pedersen, Peter Skov Esbech, Ida Kuhlmann

Publikováno v: Kuhlmann, I, Arnspang Pedersen, S, Skov Esbech, P, Bjerregaard Stage, T, Hougaard Christensen, M M & Brøsen, K 2021, ' Using a limited sampling strategy to investigate the interindividual pharmacokinetic variability in metformin : A large prospective trial ', British Journal of Clinical Pharmacology, vol. 87, no. 4, pp. 1963-1969 . https://doi.org/10.1111/bcp.14591

Aims: Recently a limited sampling strategy (LSS) for determination of metformin' pharmacokinetics was developed. The LSS utilizes the plasma concentration of metformin 3 and 10 hours after oral intake of a single dose to estimate the area under the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646972af0eb41422f766cef9a159e6a0
https://findresearcher.sdu.dk:8443/ws/files/174894174/bcp.14591.pdf

The Danish model for the quick and safe implementation of infliximab and etanercept biosimilars

Autor: Stig Andersen, Thomas Bo Jensen, Hanne Rolighed Christensen, Dorthe Bartels, Mette Marie Hougaard Christensen, Eva Aggerholm Sædder, Lars Peter Nielsen, Birgitte Klindt Poulsen

Publikováno v: Jensen, T B, Bartels, D, Sædder, E A, Poulsen, B K, Andersen, S E, Christensen, M M H, Nielsen, L & Christensen, H R 2020, ' The Danish model for the quick and safe implementation of infliximab and etanercept biosimilars ', European Journal of Clinical Pharmacology, vol. 76, no. 1, pp. 35–40 . https://doi.org/10.1007/s00228-019-02765-3
Jensen, T B, Bartels, D, Sædder, E A, Poulsen, B K, Andersen, S E, Christensen, M M H, Nielsen, L & Christensen, H R 2020, ' The Danish model for the quick and safe implementation of infliximab and etanercept biosimilars ', European Journal of Clinical Pharmacology, vol. 76, no. 1, pp. 35-40 . https://doi.org/10.1007/s00228-019-02765-3

Purpose A rapidly increasing use of biological drugs has led to substantial costs. Shift to biosimilars enables considerable reduction of these costs without jeopardizing the treatment of patients, but most countries have extensive possibilities of u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafd9a0788c1ad2f93650d75928bf814
https://vbn.aau.dk/da/publications/253195a6-4e8a-4934-ad4f-d6895a914a7b