Výsledky vyhledávání - "Mette Viberg Østergaard"

MO069: Therapeutic Effects of Semaglutide as Mono and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease

Autor: Michael Christensen, Louise S Dalbøge, Thomas Secher, Casper Gravesen Salinas, Rune Ida, Henrik Björk Hansen, Lisbeth N Fink, Mette Viberg Østergaard

Publikováno v: Nephrology Dialysis Transplantation. 37

BACKGROUND AND AIMS Obesity, hyperglycemia and hypertension are critical risk factors for the onset and progression of diabetic kidney disease (DKD). Emerging evidence suggests that sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9efc486a1a74a5fc7759bc4fc8153c1b
https://doi.org/10.1093/ndt/gfac063.021

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Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor

Autor: Lan Ni, Ruth Rollason, Richard J M Coward, Gavin I. Welsh, Abigail C Lay, Mette Viberg Østergaard, Grace Pearson, Hellyeh Hamidi, Virginie M S Betin, Lawrence Gillam, Jenny A Hurcombe, Rachel Lennon, Fern Barrington

Publikováno v: Diabetologia
Lay, A C, Hurcombe, J A, Betin, V M S, Barrington, F, Rollason, R, Ni, L, Gillam, L, Pearson, G M E, Østergaard, M V, Hamidi, H, Lennon, R, Welsh, G I & Coward, R J M 2017, ' Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor ', Diabetologia, vol. 60, no. 11, pp. 2299-2311 . https://doi.org/10.1007/s00125-017-4394-0
Lay, A C, Hurcombe, J, Betin, V, Barrington, F, Rollason, R, Ni, L, Gillam, L, Pearson, G M E, Østergaard, M V, Hamidi, H, Lennon, R, Welsh, G & Coward, R 2017, ' Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor ', Diabetologia . https://doi.org/10.1007/s00125-017-4394-0

Aims/hypothesis Podocytes are insulin-responsive cells of the glomerular filtration barrier and are key in preventing albuminuria, a hallmark feature of diabetic nephropathy. While there is evidence that a loss of insulin signalling to podocytes is d

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Mastiha ( Pistacia lentiscus ) Improves Gut Microbiota Diversity, Hepatic Steatosis, and Disease Activity in a Biopsy‐Confirmed Mouse Model of Advanced Non‐Alcoholic Steatohepatitis and Fibrosis

Autor: George Dedoussis, Giuseppe D'Auria, Claire Kammermeier, Andreas Nygaard Madsen, M. Pilar Francino, Martin Stephan, Uwe Schwahn, Aimo Kannt, Nuria Jiménez-Hernández, Mette Viberg Østergaard, Efstathia Papada

Publikováno v: Molecular Nutrition & Food Research

Scope As a result of the obesity epidemic, the prevalence of non‐alcoholic steatohepatitis (NASH) is increasing. No drug is approved for the treatment of NASH. In this study, the effect of a nutritional supplement, Mastiha or Chios mastic gum, on m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdf57ca76ca13d7f1c3ed374b845fad

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