Synthesis of Oxacyclic Scaffolds via Dual Ruthenium Hydride/Brønsted Acid-Catalyzed Isomerization/Cyclization of Allylic Ethers

Autor: David Tanner, Rico Petersen, Erhad Ascic, Thomas E. Nielsen, Mette Reimert Hansen, Ragnhild Gaard Ohm, Casper Lykke Hansen, Daniel Esmarch Madsen

Publikováno v: Chemistry - A European Journal. 20:3297-3300

A ruthenium hydride/Brønsted acid-catalyzed tandem sequence is reported for the synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]indoles (THPIs) and related oxacyclic scaffolds. The process was designed on the premise that readily available allylic ether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce469cd1d4a73ff2708088b4bb91a874
https://doi.org/10.1002/chem.201304270

Combining the Petasis 3-component reaction with multiple modes of cyclization: a build/couple/pair strategy for the synthesis of densely functionalized small molecules

Autor: Thomas Flagstad, Thomas E. Nielsen, Mette Reimert Hansen, Sebastian Thordal Le Quement, Michael Givskov

Publikováno v: ACS combinatorial science. 17(1)

A build/couple/pair strategy for the synthesis of complex and densely functionalized small molecules is presented. The strategy relies on synthetically tractable building blocks (build), that is, diversely substituted hydrazides, α-hydroxy aldehydes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d0ba8987114e5cfd70f1776379e366
https://pubmed.ncbi.nlm.nih.gov/25469710

Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

Autor: Tim Tolker-Nielsen, Mette Reimert Hansen, Michael Givskov, Tim Holm Jakobsen, Thomas E. Nielsen, Olivier Taboureau, Sebastian Thordal Le Quement, Søren Skovstrup

Publikováno v: Chembiochem : a European journal of chemical biology. 15(3)

Bacteria use small signaling molecules to communicate in a process termed “quorum sensing” (QS), which enables the coordination of survival strategies, such as production of virulence factors and biofilm formation. In Gram-negative bacteria, thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49f04eb8fe517b7bb256e73855cf2cb
https://pubmed.ncbi.nlm.nih.gov/24436223

Petasis Three-Component Coupling Reactions of Hydrazides for the Synthesis of Oxadiazolones and Oxazolidinones

Autor: Thomas Flagstad, Thomas E. Nielsen, Michael Givskov, Mette Reimert Hansen, Remi Jacob Thomsen Mikkelsen, Sebastian Thordal Le Quement

Publikováno v: Le Quement, S T, Flagstad, T, Mikkelsen, R J T, Hansen, M R, Givskov, M C & Nielsen, T E 2012, ' Petasis Three-Component Coupling Reactions of Hydrazides for the Synthesis of Oxadiazolones and Oxazolidinones ', Organic Letters, vol. 14, no. 2, pp. 640-643 . https://doi.org/10.1021/ol203280b

An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcoh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7a4e4f46894c21a8ca41cf4c729b53
https://orbit.dtu.dk/en/publications/689fc919-ee7c-421f-8fbc-e3087942cb40