Hindbrain circuits in the control of eating behaviour and energy balance

Autor: Wenwen Cheng, Desiree Gordian, Mette Q. Ludwig, Tune H. Pers, Randy J. Seeley, Martin G. Myers

Publikováno v: Nature Metabolism. 4:826-835

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6a9544fb9f0d8f93c585694ecb69b8c
https://doi.org/10.1038/s42255-022-00606-9

GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity

Autor: Sarah Falk, Jonas Petersen, Charlotte Svendsen, Cesar R. Romero-Leguizamón, Søren Heide Jørgensen, Nathalie Krauth, Mette Q. Ludwig, Kathrine Lundø, Urmas Roostalu, Grethe Skovbjerg, Duy Anh Gurskov Nielsen, Aske Lykke Ejdrup, Tune H. Pers, Oksana Dmytriyeva, Jacob Hecksher-Sørensen, Ulrik Gether, Kristi A. Kohlmeier, Christoffer Clemmensen

Publikováno v: Falk, S, Petersen, J O, Svendsen, C S A, Leguizamon, C R R, Jørgensen, S H, Krauth, N, Ludwig, M Q, Lundø, K, Roostalu, U, Hjort-Gregersen, G S, Nielsen, D A G, Ejdrup, A L, Pers, T H, Dmytriyeva, O, Hecksher-Soerensen, J, Gether, U, Kohlmeier, K A & Clemmensen, C 2023, ' GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity ', Cell Reports, vol. 42, no. 5, 112466 . https://doi.org/10.1016/j.celrep.2023.112466

Glucagon-like peptide-1 receptor (GLP-1R) agonists promote nicotine avoidance. Here, we show that the crosstalk between GLP-1 and nicotine extends beyond effects on nicotine self-administration and can be exploited pharmacologically to amplify the an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e039f98ee08a450e7a8844a6cc07ce38
https://curis.ku.dk/ws/files/346487639/1_s2.0_S2211124723004771_main.pdf

A genetic map of the mouse dorsal vagal complex and its role in obesity

Autor: Stine N Hansen, Desiree Gordian, Lotte Bjerre Knudsen, Sarah J Paulsen, Mette Q Ludwig, Martin G. Myers, Christopher J. Rhodes, Tune H. Pers, Wenwen Cheng, Anna Secher, Charles Pyke, Julie Lee, Kristoffer L. Egerod, Pernille Barkholt

Publikováno v: Nature Metabolism. 3:530-545

The brainstem dorsal vagal complex (DVC) is known to regulate energy balance and is the target of appetite-suppressing hormones, such as glucagon-like peptide 1 (GLP-1). Here we provide a comprehensive genetic map of the DVC and identify neuronal pop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ef0cddb8b41c7acd82d947677cda716
https://doi.org/10.1038/s42255-021-00363-1

A genetic map of the mouse dorsal vagal complex and its role in obesity

Autor: Mette Q, Ludwig, Wenwen, Cheng, Desiree, Gordian, Julie, Lee, Sarah J, Paulsen, Stine N, Hansen, Kristoffer L, Egerod, Pernille, Barkholt, Christopher J, Rhodes, Anna, Secher, Lotte Bjerre, Knudsen, Charles, Pyke, Martin G, Myers, Tune H, Pers

Publikováno v: Nature metabolism. 3(4)

The brainstem dorsal vagal complex (DVC) is known to regulate energy balance and is the target of appetite-suppressing hormones, such as glucagon-like peptide 1 (GLP-1). Here we provide a comprehensive genetic map of the DVC and identify neuronal pop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2eda6be79972a4837e72ed68744e898
https://pubmed.ncbi.nlm.nih.gov/33767443