Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Mette M Rosenkilde"'
Autor:
Christian Berg, Michael J Wedemeyer, Motiejus Melynis, Roman R Schlimgen, Lasse H Hansen, Jon Våbenø, Francis C Peterson, Brian F Volkman, Mette M Rosenkilde, Hans R Lüttichau
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010355 (2022)
Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised patients. The UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 different CXC chemokines. One genotype (vCXCL1GT1) is a known agonist for CXCR1 and
Externí odkaz:
https://doaj.org/article/b58f3e9f294b4bb682ffd33432ab9a5c
Autor:
Christian Berg, Martin B Friis, Mette M Rosenkilde, Thomas Benfield, Lene Nielsen, Hans R Lüttichau, Thomas Sundelin
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222053 (2019)
Congenital cytomegalovirus (CMV) infection is a major cause of birth defects ranging from developmental disorders to stillbirth. Most newborns affected by CMV do not present with symptoms at birth but are at risk of sequelae at later stages of their
Externí odkaz:
https://doaj.org/article/e6c8d7efbc7d40ff86808732916bbbde
Autor:
Timothy F Miles, Katja Spiess, Kevin M Jude, Naotaka Tsutsumi, John S Burg, Jessica R Ingram, Deepa Waghray, Gertrud M Hjorto, Olav Larsen, Hidde L Ploegh, Mette M Rosenkilde, K Christopher Garcia
Publikováno v:
eLife, Vol 7 (2018)
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink’ to facilitate evasion of host immune responses. To probe the molecular basis of US28’s unique ligand cr
Externí odkaz:
https://doaj.org/article/ff0943aefac04d7b91e5b86d46807864
Autor:
Víctor González-Motos, Carina Jürgens, Birgit Ritter, Kai A Kropp, Verónica Durán, Olav Larsen, Anne Binz, Werner J D Ouwendijk, Tihana Lenac Rovis, Stipan Jonjic, Georges M G M Verjans, Beate Sodeik, Thomas Krey, Rudolf Bauerfeind, Thomas F Schulz, Benedikt B Kaufer, Ulrich Kalinke, Amanda E I Proudfoot, Mette M Rosenkilde, Abel Viejo-Borbolla
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006346 (2017)
Varicella zoster virus (VZV) is a highly prevalent human pathogen that establishes latency in neurons of the peripheral nervous system. Primary infection causes varicella whereas reactivation results in zoster, which is often followed by chronic pain
Externí odkaz:
https://doaj.org/article/67a7306e93734a6fb0c1a6b9d1cccf9f
Autor:
Gertrud Malene Hjortø, Olav Larsen, Anne Steen, Christian Berg, Viktorija Daugvilaite, Suzan Fares, Morten Hansen, Simi Ali, Mette M Rosenkilde
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The CCR7 ligands CCL19 and CCL21 are increasingly recognized as functionally different (biased). Using mature human dendritic cells (DCs), we show that CCL19 is more potent than CCL21 in inducing 3D chemotaxis. Intriguingly, CCL21 induces prolonged a
Externí odkaz:
https://doaj.org/article/17e2402f4682476ba3ca39d86fdef0ae
Autor:
Mette H. Jensen, Samra J. Sanni, Ditte Riber, Jens J. Holst, Mette M. Rosenkilde, Alexander H. Sparre-Ulrich
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 102006- (2024)
Objectives: Obesity represents a global health crisis with significant patient burdens and healthcare costs. Despite the advances with glucagon-like peptide-1 (GLP-1) receptor agonists in treating obesity, unmet needs remain. This study characterizes
Externí odkaz:
https://doaj.org/article/25f7b2dd9c3443ce984912d0de8ad0d3
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Biased signaling or functional selectivity occurs when a 7TM receptor preferentially activates one of several available pathways. It can be divided into three distinct forms: ligand bias, receptor bias, and tissue or cell bias, where it is mediated b
Externí odkaz:
https://doaj.org/article/4061137081dc4de1a72af09b318fa699
Autor:
Luna Dillemans, Karen Yu, Alexandra De Zutter, Sam Noppen, Mieke Gouwy, Nele Berghmans, Lisa Verhallen, Mirre De Bondt, Lotte Vanbrabant, Stef Brusselmans, Erik Martens, Dominique Schols, Patrick Verschueren, Mette M. Rosenkilde, Pedro Elias Marques, Sofie Struyf, Paul Proost
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract Background Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupled receptor (GPCR), C
Externí odkaz:
https://doaj.org/article/632073f48a4041208b11f2b4ff94603b
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24644 (2011)
BackgroundThe melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60
Externí odkaz:
https://doaj.org/article/dd39398976824e9baf73414537ea5c3f
Autor:
Andreas Lindqvist, Mia Abels, Liliya Shcherbina, Mtakai Ngara, Dmytro Kryvokhyzha, Sabrina Chriett, Matteo Riva, Abul Fajul, Mohammad Barghouth, Cheng Luan, Lena Eliasson, Olav Larsen, Mette M. Rosenkilde, Enming Zhang, Erik Renström, Nils Wierup
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108416- (2023)
Summary: Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreat
Externí odkaz:
https://doaj.org/article/5b28e5d6ce9a49798e8b5a806ad188f3