Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Mette Juul Nielsen"'
Autor:
Diana Julie Leeming, Signe Holm Nielsen, Roslyn Vongsuvanh, Pruthviraj Uchila, Mette Juul Nielsen, Alexander L Reese-Petersen, David van der Poorten, Mohammed Eslam, Detlef Schuppan, Morten Asser Karsdal, Jacob George
Publikováno v:
Hepatic Oncology, Vol 8, Iss 2 (2021)
Aim: Type VI collagen, is emerging as a signaling collagen originating from different types of fibroblasts. A specific fragment of Type VI collagen, the pro-peptide, is also known as the hormone endotrophin. We hypothesized that this fibroblast hormo
Externí odkaz:
https://doaj.org/article/245b0969dbbd426da0012c72c208c7a8
Autor:
Signe Holm Nielsen, Nicholas Willumsen, Diana Julie Leeming, Samuel Joseph Daniels, Susanne Brix, Morten Asser Karsdal, Federica Genovese, Mette Juul Nielsen
Publikováno v:
Translational Oncology, Vol 12, Iss 2, Pp 368-374 (2019)
OBJECTIVES: Remodeling of the extracellular matrix (ECM) is a key event in different lung disorders, such as fibrosis and cancer. The most common cell type in the connective tissue is fibroblasts, which transdifferentiate into myofibroblasts upon act
Externí odkaz:
https://doaj.org/article/61a2dabba2604d58a5d86e2ce252cb60
Autor:
Mette Vesterhus, Mette Juul Nielsen, Johannes Roksund Hov, Francesca Saffioti, Tina Manon-Jensen, Diana Julie Leeming, Bjørn Moum, Kirsten Muri Boberg, Massimo Pinzani, Tom Hemming Karlsen, Morten Asser Karsdal, Douglas Thorburn
Publikováno v:
JHEP Reports, Vol 3, Iss 1, Pp 100178- (2021)
Background & Aims: Primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) are phenotypically distinct autoimmune liver diseases that progress to cirrhosis and liver failure; however, their histological
Externí odkaz:
https://doaj.org/article/2f27a591714d49d793cb4ff26417f722
Autor:
Eveline Gart, Wim van Duyvenvoorde, Karin Toet, Martien P. M. Caspers, Lars Verschuren, Mette Juul Nielsen, Diana Julie Leeming, Everton Souto Lima, Aswin Menke, Roeland Hanemaaijer, Jaap Keijer, Kanita Salic, Robert Kleemann, Martine C. Morrison
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1954 (2021)
In obesity-associated non-alcoholic steatohepatitis (NASH), persistent hepatocellular damage and inflammation are key drivers of fibrosis, which is the main determinant of NASH-associated mortality. The short-chain fatty acid butyrate can exert metab
Externí odkaz:
https://doaj.org/article/d68615dbae2a4f9ab2273c659445ae93
Autor:
Nina Kimer, Natasja Stæhr Gudmann, Julie Steen Pedersen, Søren Møller, Mette Juul Nielsen, Diana Julie Leeming, Morten Asser Karsdal, Holger Jon Møller, Flemming Bendtsen, Henning Grønbæk
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203200 (2018)
BACKGROUND AND AIMS:Macrophages play a significant role in chronic liver disease as reflected by elevated soluble (s)CD163 and mannose receptor (sMR) levels and associated with liver disease severity and prognosis. Extracellular matrix remodelling as
Externí odkaz:
https://doaj.org/article/192180fcb8e04db6a3cc186e0781367b
Autor:
Robert eSchierwagen, Sabine eKlein, Diana Julie Leeming, Michaela eGranzow, Mette Juul Nielsen, Tilman eSauerbruch, Aleksander eKrag, Morten A Karlsdal, Jonel eTrebicka
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
BackgroundProgression of liver fibrosis is characterized by synthesis and degradation of extracellular matrix (ECM). Matrix-metalloproteinases (MMP) cleave collagen fibers at a specific site and thereby generate soluble fragments of ECM (neo-epitopes
Externí odkaz:
https://doaj.org/article/2748dddda4e04453a814d379d71edec5
Autor:
Ida Lønsmann, Julie Steen Pedersen, Aleksander Krag, Torben Hansen, Morten Karsdal, Diana Julie Leeming, Mette Juul Nielsen, Flemming Bendtsen
Publikováno v:
Clinical Biochemistry. 113:29-35
Non-invasive tests for non-alcoholic fatty liver disease (NAFLD) are needed for assessing disease stage, prognosis and treatment efficacy. Extracellular matrix biomarkers, such as PRO-C3, are useful as biomarkers of advanced liver fibrosis. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75187f9c48b819331d0223ae65a6640
https://doi.org/10.1016/j.clinbiochem.2022.12.012
https://doi.org/10.1016/j.clinbiochem.2022.12.012
Autor:
Shuyan Du, Diane E. Shevell, Warner Chen, Edgar D. Charles, Uma Kavita, Angie Coste, Fred Poordad, Zachary Goodman, Eric Lawitz, Mette Juul Nielsen, Giridhar S. Tirucherai, Morten A. Karsdal
Publikováno v:
Hepatology. 75:912-923
Background & aims Hepatic fibrosis secondary to HCV infection can lead to cirrhosis and hepatic decompensation. Sustained virologic response (SVR) is possible with direct-acting antiviral drug regimens; however, patients with advanced fibrosis have a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e802021fa75e6b6ce3e5c628a8f75647
https://doi.org/10.1002/hep.32181
https://doi.org/10.1002/hep.32181
Autor:
Maria Kjærgaard, Mette Juul Nielsen, Maja Thiele, Diana Julie Leeming, Jonel Trebicka, Aleksander Krag, Bjørn Stæhr Madsen, Morten A. Karsdal, Sönke Detlefsen, Linda Maria Sevelsted Møller, Natasja Stæhr Gudmann
Publikováno v:
Madsen, B S, Thiele, M, Detlefsen, S, Kjaergaard, M, Møller, L S, Trebicka, J, Nielsen, M J, Gudmann, N S, Leeming, D J, Karsdal, M A & Krag, A 2021, ' PRO-C3 and ADAPT algorithm accurately identify patients with advanced fibrosis due to alcohol-related liver disease ', Alimentary Pharmacology & Therapeutics, vol. 54, no. 5, pp. 699-708 . https://doi.org/10.1111/apt.16513
BACKGROUND: Alcohol is a main cause of preventable deaths and frequently leads to the development of alcohol-related liver disease. Due to the lack of diagnostics, patients are commonly diagnosed after developing clinical manifestations. Recently, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4271f725ec8b6cf5523b171e995b054e
https://doi.org/10.1111/apt.16513
https://doi.org/10.1111/apt.16513
Autor:
Miriam B. Vos, Diane E. Shevell, Diana Julie Leeming, Rebecca Cleeton, Catherine C. Cohen, Morten A. Karsdal, Shelley A. Caltharp, Alton B. Farris, Elizabeth M. Sinclair, Mette Juul Nielsen, Eduardo Castillo‐Leon
Publikováno v:
Hepatology Communications, Vol 5, Iss 11, Pp 1860-1872 (2021)
Hepatology Communications
Hepatology Communications
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may lead to cirrhosis requiring liver transplant. Thus, prompt diagnosis of advanced fibrosis is essential. Our objectives were to examine PRO‐C3 (a neo‐ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9fa3f5f4300f8acd472cd55332dd44
https://doi.org/10.1002/hep4.1766
https://doi.org/10.1002/hep4.1766