Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mette Juul Jacobsen"'
Autor:
Mette Juul Jacobsen, Jakob H. Havgaard, Christian Anthon, Caroline M. Junker Mentzel, Susanna Cirera, Poula Maltha Krogh, Sachin Pundhir, Peter Karlskov-Mortensen, Camilla S. Bruun, Philippe Lesnik, Maryse Guerin, Jan Gorodkin, Claus B. Jørgensen, Merete Fredholm, Romain Barrès
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Reprogramming of adipocyte function in obesity is implicated in metabolic disorders like type 2 diabetes. Here, we used the pig, an animal model sharing many physiological and pathophysiological similarities with humans, to perform in-depth epigenomi
Externí odkaz:
https://doaj.org/article/3694cf17ee5f4b5aa9d134ca74b090ee
Autor:
Emilio Mármol‐Sánchez, Susanna Cirera, Laura M. Zingaretti, Mette Juul Jacobsen, Yuliaxis Ramayo‐Caldas, Claus B. Jørgensen, Merete Fredholm, Tainã Figueiredo Cardoso, Raquel Quintanilla, Marcel Amills
Publikováno v:
Animal Genetics. 53:613-626
The contribution of microRNAs (miRNAs) to mRNA post-transcriptional regulation has often been explored by the post hoc selection of downregulated genes and determining whether they harbor binding sites for miRNAs of interest. This approach, however,
Autor:
Laura M. Zingaretti, Yuliaxis Ramayo-Caldas, Raquel Quintanilla, Merete Fredholm, Susanna Cirera, Tainã Figueiredo Cardoso, Emilio Mármol-Sánchez, Marcel Amills, Claus Jørgensen, Mette Juul Jacobsen
The contribution of microRNAs (miRNAs) to mRNA regulation has often been explored by post hoc selection of downregulated genes and determining whether they harbor binding sites for miRNAs of interest. This approach, however, does not discriminate whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed780e7989a684aee37521624308cc7d
https://doi.org/10.1101/2021.07.14.452370
https://doi.org/10.1101/2021.07.14.452370
Autor:
Mette Juul Jacobsen, Merete Fredholm, Christian Bressen Pipper, Susanna Cirera, Caroline M. Junker Mentzel, Tainã Figueiredo Cardoso, Claus Jørgensen
Publikováno v:
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
The aim of this study was to elucidate the relative impact of three phenotypes often used to characterize obesity on perturbation of molecular pathways involved in obesity. The three obesity-related phenotypes are (1) body mass index (BMI), (2) amoun
Autor:
Henrik D. Pedersen, Berit Østergaard Christoffersen, Camilla Schumacher-Petersen, Rikke Kaae Kirk, Lisbeth H. Olsen, Trine Pagh Ludvigsen, Mette Juul Jacobsen, Susanna Cirera, Emirhan Taşöz, Merete Fredholm, Henning Hvid
Publikováno v:
Nutrition & Diabetes
Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-12 (2020)
Cirera, S, Taşöz, E, Juul Jacobsen, M, Schumacher-Petersen, C, Østergaard Christoffersen, B, Kaae Kirk, R, Pagh Ludvigsen, T, Hvid, H, Duelund Pedersen, H, Høier Olsen, L & Fredholm, M 2020, ' The expression signatures in liver and adipose tissue from obese Göttingen Minipigs reveal a predisposition for healthy fat accumulation ', Nutrition and Diabetes, vol. 10, no. 1, 9 . https://doi.org/10.1038/s41387-020-0112-y
Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-12 (2020)
Cirera, S, Taşöz, E, Juul Jacobsen, M, Schumacher-Petersen, C, Østergaard Christoffersen, B, Kaae Kirk, R, Pagh Ludvigsen, T, Hvid, H, Duelund Pedersen, H, Høier Olsen, L & Fredholm, M 2020, ' The expression signatures in liver and adipose tissue from obese Göttingen Minipigs reveal a predisposition for healthy fat accumulation ', Nutrition and Diabetes, vol. 10, no. 1, 9 . https://doi.org/10.1038/s41387-020-0112-y
Background Model animals are valuable resources for dissecting basic aspects of the regulation of obesity and metabolism. The translatability of results relies on understanding comparative aspects of molecular pathophysiology. Several studies have sh
Autor:
Sachin Pundhir, Maryse Guerin, Caroline M. Junker Mentzel, Romain Barrès, Jan Gorodkin, Mette Juul Jacobsen, Claus Jørgensen, Camilla S. Bruun, Susanna Cirera, Poula Maltha Krogh, Peter Karlskov-Mortensen, Philippe Lesnik, Jakob Hull Havgaard, Merete Fredholm, Christian Anthon
Publikováno v:
Jacobsen, M J, Havgaard, J H, Anthon, C, Mentzel, C M J, Cirera, S, Krogh, P M, Pundhir, S, Karlskov-Mortensen, P, Bruun, C S, Lesnik, P, Guerin, M, Gorodkin, J, Jørgensen, C B, Fredholm, M & Barrès, R 2019, ' Epigenetic and Transcriptomic Characterization of Pure Adipocyte Fractions From Obese Pigs Identifies Candidate Pathways Controlling Metabolism ', Frontiers in Genetics, vol. 10, 1268 . https://doi.org/10.3389/fgene.2019.01268
Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics
Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics
Reprogramming of adipocyte function in obesity is implicated in metabolic disorders like type 2 diabetes. Here, we used the pig, an animal model sharing many physiological and pathophysiological similarities with humans, to perform in-depth epigenomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062f08fe67afbe6e58e2313e1292b84f
https://curis.ku.dk/portal/da/publications/epigenetic-and-transcriptomic-characterization-of-pure-adipocyte-fractions-from-obese-pigs-identifies-candidate-pathways-controlling-metabolism(d2ed34d7-97c8-4694-915c-dd68dd5da637).html
https://curis.ku.dk/portal/da/publications/epigenetic-and-transcriptomic-characterization-of-pure-adipocyte-fractions-from-obese-pigs-identifies-candidate-pathways-controlling-metabolism(d2ed34d7-97c8-4694-915c-dd68dd5da637).html
Autor:
Merete Fredholm, Peter Karlskov-Mortensen, Maryse Guerin, Alex Clop, Philippe Lesnik, Mette Juul Jacobsen, Claus Jørgensen, Susanna Cirera
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Taste receptors (TASRs) and appetite and reward (AR) mechanisms influence eating behaviour, which in turn affects food intake and risk of obesity. In a previous study, we used next generation sequencing to identify potentially functional mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3a0c9aa4f5ed02b3c76b37ae116252
http://hdl.handle.net/10261/248100
http://hdl.handle.net/10261/248100
Autor:
Christian Anthon, Caroline M. Junker Mentzel, Jan Gorodkin, Camilla S. Bruun, Merete Fredholm, Susanna Cirera, Peter Karlskov-Mortensen, Mette Juul Jacobsen, Claus Jørgensen
Publikováno v:
PLoS ONE
Mentzel, C M J, Anthon, C, Jacobsen, M J, Karlskov-Mortensen, P, Bruun, C V S, Jørgensen, C B, Gorodkin, J, Cirera Salicio, S & Fredholm, M 2015, ' Gender and obesity specific MicroRNA expression in adipose tissue from lean and obese pigs ', P L o S One, vol. 10, no. 7, e0131650 . https://doi.org/10.1371/journal.pone.0131650
PLoS ONE, Vol 10, Iss 7, p e0131650 (2015)
Mentzel, C M J, Anthon, C, Jacobsen, M J, Karlskov-Mortensen, P, Bruun, C V S, Jørgensen, C B, Gorodkin, J, Cirera Salicio, S & Fredholm, M 2015, ' Gender and obesity specific MicroRNA expression in adipose tissue from lean and obese pigs ', P L o S One, vol. 10, no. 7, e0131650 . https://doi.org/10.1371/journal.pone.0131650
PLoS ONE, Vol 10, Iss 7, p e0131650 (2015)
Obesity is a complex condition that increases the risk of life threatening diseases such as cardiovascular disease and diabetes. Studying the gene regulation of obesity is important for understanding the molecular mechanisms behind the obesity derive
Autor:
Merete Fredholm, Claus Jørgensen, Susanna Cirera, Emil V. R. Appel, Niels Grarup, Torben Hansen, Thierry Huby, Ehm A.A. Galjatovic, Mette Juul Jacobsen, Oluf Pedersen, Camilla S. Bruun, Philipppe Lesnik, Maryse Guerin, Sameer D. Pant, Thomas Mark, Peter Karlskov-Mortensen, Haja N. Kadarmideen, Lisette J. A. Kogelman, Theodorus Meuwissen
Publikováno v:
PLoS ONE
PLoS ONE, 2015, 10 (9), pp.e0137356. ⟨10.1371/journal.pone.0137356⟩
PLoS ONE, Public Library of Science, 2015, 10 (9), pp.e0137356. ⟨10.1371/journal.pone.0137356⟩
Pant, S D, Karlskov-Mortensen, P, Jacobsen, M J, Cirera Salicio, S, Kogelman, L, Bruun, C V S, Mark, T, Jørgensen, C B, Grarup, N, Appel, E V R, Galjatovic, E A A, Hansen, T, Pedersen, O B, Guerin, M, Huby, T, Lesnik, P, Meuwissen, T H E, Kadarmideen, H & Fredholm, M 2015, ' Comparative analyses of QTLs influencing obesity and metabolic phenotypes in pigs and humans ', PLOS ONE, vol. 10, no. 9, e0137356 . https://doi.org/10.1371/journal.pone.0137356
PLoS ONE, Vol 10, Iss 9, p e0137356 (2015)
PLoS ONE, 2015, 10 (9), pp.e0137356. ⟨10.1371/journal.pone.0137356⟩
PLoS ONE, Public Library of Science, 2015, 10 (9), pp.e0137356. ⟨10.1371/journal.pone.0137356⟩
Pant, S D, Karlskov-Mortensen, P, Jacobsen, M J, Cirera Salicio, S, Kogelman, L, Bruun, C V S, Mark, T, Jørgensen, C B, Grarup, N, Appel, E V R, Galjatovic, E A A, Hansen, T, Pedersen, O B, Guerin, M, Huby, T, Lesnik, P, Meuwissen, T H E, Kadarmideen, H & Fredholm, M 2015, ' Comparative analyses of QTLs influencing obesity and metabolic phenotypes in pigs and humans ', PLOS ONE, vol. 10, no. 9, e0137356 . https://doi.org/10.1371/journal.pone.0137356
PLoS ONE, Vol 10, Iss 9, p e0137356 (2015)
International audience; The pig is a well-known animal model used to investigate genetic and mechanistic aspects of human disease biology. They are particularly useful in the context of obesity and metabolic diseases because other widely used models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8155a4ef0610008bdf5c211b1e2249b4
https://hal.sorbonne-universite.fr/hal-01275896
https://hal.sorbonne-universite.fr/hal-01275896
Autor:
Haja N. Kadarmideen, Claus Jørgensen, Mette Juul Jacobsen, Lisette J. A. Kogelman, Merete Fredholm, Camilla S. Bruun, Thomas Mark, Peter Karlskov-Mortensen, Susanna Cirera
Publikováno v:
Frontiers in Genetics
Kogelman, L, Kadarmideen, H, Mark, T, Karlskov-Mortensen, P, Bruun, C V S, Cirera Salicio, S, Jacobsen, M J, Jørgensen, C B & Fredholm, M 2013, ' An F2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans : design and genetic parameters ', Frontiers in Genetics, vol. 4, 29 . https://doi.org/10.3389/fgene.2013.00029
Frontiers in Genetics, Vol 4 (2013)
Kogelman, L, Kadarmideen, H, Mark, T, Karlskov-Mortensen, P, Bruun, C V S, Cirera Salicio, S, Jacobsen, M J, Jørgensen, C B & Fredholm, M 2013, ' An F2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans : design and genetic parameters ', Frontiers in Genetics, vol. 4, 29 . https://doi.org/10.3389/fgene.2013.00029
Frontiers in Genetics, Vol 4 (2013)
Obesity is a rising worldwide public health problem. Difficulties to precisely measure various obesity traits and the genetic heterogeneity in human have been major impediments to completely disentangle genetic factors causing obesity. The pig is a r