Sequence-Based Genotyping of Expressed Swine Leukocyte Antigen Class I Alleles by Next-Generation Sequencing Reveal Novel Swine Leukocyte Antigen Class I Haplotypes and Alleles in Belgian, Danish, and Kenyan Fattening Pigs and Göttingen Minipigs

Autor: Mikael Lenz Strube, Richard P. Bishop, Sofie Bruun Hartmann, Gitte Erbs, Maria Rathmann Sørensen, Gregers Jungersen, Mette Ilsøe

Publikováno v: Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology
Sørensen, M R, Ilsøe, M, Strube, M L, Bishop, R, Erbs, G, Hartmann, S B & Jungersen, G 2017, ' Sequence-Based Genotyping of Expressed Swine Leukocyte Antigen Class I Alleles by Next-Generation Sequencing Reveal Novel Swine Leukocyte Antigen Class I Haplotypes and Alleles in Belgian, Danish, and Kenyan Fattening Pigs and Göttingen Minipigs ', Frontiers in Immunology, vol. 8, 701 . https://doi.org/10.3389/fimmu.2017.00701

The need for typing of the swine leukocyte antigen (SLA) is increasing with the expanded use of pigs as models for human diseases and organ-transplantation experiments, their use in infection studies, and for design of veterinary vaccines. Knowledge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3996fddf9db86d0e33239d3c56460bb6
http://journal.frontiersin.org/article/10.3389/fimmu.2017.00701/full

The pig as a model for therapeutic human anti-cancer vaccine development, elucidating the T-cell reactivity against IDO and RhoC

Autor: Nana Haahr Overgaard, Thomas Mørch Frøsig, Simon Welner, Michael Rasmussen, Mette Ilsøe, Maria Rathmann Sørensen, Mads Hald Andersen, Søren Buus, Gregers Jungersen

Publikováno v: Technical University of Denmark Orbit
Overgaard, N H, Frøsig, T M, Welner, S, Rasmussen, M, Ilsøe, M, Sørensen, M R, Andersen, M H, Buus, S & Jungersen, G 2015, ' The pig as a model for therapeutic human anti-cancer vaccine development, elucidating the T-cell reactivity against IDO and RhoC ', 5th European Veterinary Immunology Workshop, Vienna, Austria, 02/09/2015-04/09/2015 .

Immunotherapy against cancer has shown increased overall survival of metastatic cancer patients and is a promising new vaccine target. For this to succeed, appropriate tailoring of vaccine formulations to mount in vivo cytotoxic T cell (CTL) response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ce5f9a1472ac9c949cbf9d4b2b168591
https://orbit.dtu.dk/en/publications/ac7d253f-ced9-49a3-8c6f-a1ff7d265e29

Elucidating the T-cell reactivity against porcine IDO and RhoC to establish the pig as an animal model for vaccine development against human cancer

Autor: Nana Haahr Overgaard, Thomas Mørch Frøsig, Simon Welner, Michael Rasmussen, Mette Ilsøe, Maria Rathmann Sørensen, Mads Hald Andersen, Søren Buus, Gregers Jungersen

Publikováno v: Technical University of Denmark Orbit
Overgaard, N H, Frøsig, T M, Welner, S, Rasmussen, M, Ilsøe, M, Sørensen, M R, Andersen, M H, Buus, S & Jungersen, G 2015, ' Elucidating the T-cell reactivity against porcine IDO and RhoC to establish the pig as an animal model for vaccine development against human cancer ', The 13th Annual Meeting in the Association for Cancer Immunotherapy, Mainz, Germany, 11/05/2015-13/05/2015 .

Immune therapy of cancer has recently experienced a great breakthrough with prolonged overall survival in patients with metastatic disease following the use of checkpoint inhibitors and T cell therapy with ex vivo expanded CD8+ cytotoxic T cells (CTL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ace4494d30103f46e89c497e3894bcf0
https://orbit.dtu.dk/en/publications/91583d6b-694f-4923-97da-a905b1bd3fdb