First-in-human use of a modular capsid virus-like vaccine platform:An open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2

Autor: Merel J Smit, Adam F Sander, Maud B P A Ariaans, Cyrielle Fougeroux, Constanze Heinzel, Rolf Fendel, Meral Esen, Peter G Kremsner, Rob ter Heine, Heiman F Wertheim, Manja Idorn, Søren Riis Paludan, Alexander P Underwood, Alekxander Binderup, Santseharay Ramirez, Jens Bukh, Max Soegaard, Sayit M Erdogan, Tobias Gustavsson, Stine Clemmensen, Thor G Theander, Ali Salanti, Mette Hamborg, Willem A de Jongh, Matthew B B McCall, Morten A Nielsen, Benjamin G Mordmüller, Robert Dagil, Louise Goksøyr, Thomas M Hulen, Christoph Janitzek, Daniel S Jensen, Sune Justesen, Paul K Khalifé, Andrea Kreidenweiss, Telma Lança, Olivia Lie-Andersen, Karina Teelen, Elena Vidal-Calvo

Publikováno v: Smit, M J & COUGH-1 trial study group 2023, ' First-in-human use of a modular capsid virus-like vaccine platform : An open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2 ', The Lancet Microbe, vol. 4, no. 3, pp. e140-e148 . https://doi.org/10.1016/S2666-5247(22)00337-8
The Lancet Microbe, 4, 3, pp. e140-e148
The Lancet Microbe, 4, e140-e148

Contains fulltext : 291067.pdf (Publisher’s version ) (Open Access) BACKGROUND: Capsid virus-like particles (cVLP) have proven safe and immunogenic and can be a versatile platform to counter pandemics. We aimed to clinically test a modular cVLP COV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14ac00b940c34782ba1e1c8bde5833a
https://curis.ku.dk/ws/files/340399546/1_s2.0_S2666524722003378_main.pdf

Studies of the Aggregation of RNase Sa

Autor: Ryan Kramer, Harshit Khasa, Nathan Maddux, Sangeeta B. Joshi, Mette Hamborg, David B. Volkin, C. Russell Middaugh

Publikováno v: Journal of Pharmaceutical Sciences. 103:395-399

Thirty-eight mutants of RNase Sa (ribonuclease from Streptomyces aureofaciens) were examined for their structure, thermal sensitivity, and tendency to aggregate. Although a biphasic correlation was seen between the effect of temperature on structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3af0d2d0c09063c613fa17ed0ed9bd
https://doi.org/10.1002/jps.23841

The influence of sub-unit composition and expression system on the functional antibody response in the development of a VAR2CSA based Plasmodium falciparum placental malaria vaccine

Autor: Anette Strøbæk, Philippe Deloron, Mafalda Resende, Saddou Issifou, Morten Nielsen, Mette Hamborg, Benjamin Mordmüller, Adrian J. F. Luty, Jean-Philippe Chippaux, Willem A. de Jongh, Mette Ø. Agerbæk, Lars Poulsen, Peter G. Kremsner, Odile Leroy, Thor G. Theander, Achille Massougbodji, Charlotte Dyring, Sisse B. Ditlev, Sophie Houard, Nicaise Tuikue Ndam, Ali Salanti

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0135406 (2015)
PLoS ONE

The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such manifestation in which Pf infected erythrocytes (IE) bind to cho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8296e024e6bb54287445619349167a3d
http://www.documentation.ird.fr/hor/fdi:010065258

Protein antigen adsorption to the DDA/TDB liposomal adjuvant: effect on protein structure, stability, and liposome physicochemical characteristics

Autor: Lene Jorgensen, Dennis Christensen, Camilla Foged, Anders Riber Bojsen, Mette Hamborg

Publikováno v: Pharmaceutical research. 30(1)

Understanding the nature of adjuvant-antigen interactions is important for the future design of efficient and safe subunit vaccines, but remains an analytical challenge. We studied the interactions between three model protein antigens and the clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdba83f11d557fbbb4aba03a184d431
https://pubmed.ncbi.nlm.nih.gov/22956169