Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mette G Sørensen"'
Autor:
Kim Henriksen, Yaguo Wang, Mette G Sørensen, Natasha Barascuk, Joyce Suhy, Jan T Pedersen, Kevin L Duffin, Robert A Dean, Monika Pajak, Claus Christiansen, Qinlong Zheng, Morten A Karsdal
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64990 (2013)
ObjectiveAlzheimer's disease (AD) is a devastating neurological disease characterized by pathological proteolytic cleavage of tau protein, which appears to initiate death of the neurons. The objective of this study was to investigate whether a proteo
Externí odkaz:
https://doaj.org/article/2b6f9215175d48329c9c1c6a33b5e397
Autor:
Olivier Nosjean, Jean A. Boutin, Morten Hanefeld Dziegiel, Mette G Sørensen, Morten A. Karsdal, Vicki Kaiser Jensen, Kim Henriksen
Publikováno v:
ASSAY and Drug Development Technologies. 9:157-164
The osteoclast initiates resorption by creating a resorption lacuna. The ruffled border surrounding the lacunae arises from exocytosis of lysosomes. To dissolve the inorganic phase of the bone, the vacuolar adenosine triphosphatase, located in the ru
Autor:
A.V. Neutzsky-Wulff, Mette G Sørensen, Toni Segovia-Silvestre, Morten A. Karsdal, Kim Henriksen, Jens Bollerslev, C. Christiansen
Publikováno v:
Human Genetics. 124:561-577
Osteopetrosis is the result of mutations affecting osteoclast function. Careful analyses of osteopetrosis have provided instrumental information on bone remodeling, including the coupling of bone formation to bone resorption. Based on a range of nove
Autor:
Mette G Sørensen, Olivier Nosjean, Kim Henriksen, Morten A. Karsdal, Vicki Kaiser Jensen, Morten Hanefeld Dziegiel
Publikováno v:
Calcified Tissue International. 83:230-242
Osteoclasts possess a large amount of ion transporters, which participate in bone resorption; of these, the vacuolar-adenosine trisphosphatase (V-ATPase) and the chloride-proton antiporter ClC-7 acidify the resorption lacuna. However, whether other i
Autor:
Morten Hanefeld Dziegiel, Mette G Sørensen, Sophie Schaller, Kim Henriksen, Finn Cilius Nielsen, Morten A. Karsdal, Dennis Bang Henriksen
Publikováno v:
Journal of Bone and Mineral Metabolism. 25:36-45
Bone resorption is solely mediated by osteoclasts. Therefore, a pure osteoclast population is of high interest for the investigation of biological aspects of the osteoclasts, such as the direct effect of growth factors and hormones, as well as for te
Autor:
Jeppe Gram, Jens Bollerslev, Morten Hanefeld Dziegiel, Kim Henriksen, Sophie Schaller, Morten A. Karsdal, Mette G Sørensen, R.H. Nielsen, Vincent Everts
Publikováno v:
Journal of Bone and Mineral Research, 21, 58-66. American Society for Bone and Mineral Research
Henriksen, K, Sorensen, M G, Nielsen, R H, Gram, J, Schaller, S, Dziegiel, M H, Everts, V, Bollerslev, J & Karsdal, M A 2006, ' Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification ', Journal of Bone and Mineral Research, vol. 21, pp. 58-66 . https://doi.org/10.1359/JBMR.050905
Henriksen, K, Sørensen, M G, Nielsen, R H, Gram, J, Schaller, S, Dziegiel, M H, Everts, V, Bollerslev, J & Karsdal, M A 2006, ' Degradation of the organic phase of bone by osteoclasts : a secondary role for lysosomal acidification ', Journal of Bone and Mineral Research, vol. 21, no. 1, pp. 58-66 .
Journal of Bone and Mineral Research, 21, 58-66. Wiley-Blackwell
Henriksen, K, Sorensen, M G, Nielsen, R H, Gram, J, Schaller, S, Dziegiel, M H, Everts, V, Bollerslev, J & Karsdal, M A 2006, ' Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification ', Journal of Bone and Mineral Research, vol. 21, pp. 58-66 . https://doi.org/10.1359/JBMR.050905
Henriksen, K, Sørensen, M G, Nielsen, R H, Gram, J, Schaller, S, Dziegiel, M H, Everts, V, Bollerslev, J & Karsdal, M A 2006, ' Degradation of the organic phase of bone by osteoclasts : a secondary role for lysosomal acidification ', Journal of Bone and Mineral Research, vol. 21, no. 1, pp. 58-66 .
Journal of Bone and Mineral Research, 21, 58-66. Wiley-Blackwell
Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that
Autor:
Jens Bollerslev, Kim Henriksen, Jeppe Gram, Sophie Schaller, Anne-Marie Heegaard, Mette G Sørensen, Thomas J. Martin, Morten Hanefeld Dziegiel, Palle Christophersen, Morten A. Karsdal, Claus Christiansen
Publikováno v:
The American Journal of Pathology. 166:467-476
Patients with defective osteoclastic acidification have increased numbers of osteoclasts, with decreased resorption, but bone formation that remains unchanged. We demonstrate that osteoclast survival is increased when acidification is impaired, and t
Autor:
A.V. Neutzsky-Wulff, Mette G Sørensen, Kim Henriksen, Morten A. Karsdal, Diana Julie Leeming, Morten Hanefeld Dziegiel, Dino Kocijancic
Publikováno v:
BMC Musculoskeletal Disorders, Vol 11, Iss 1, p 109 (2010)
BMC Musculoskeletal Disorders
BMC Musculoskeletal Disorders
Background Normal osteoclasts resorb bone by secretion of acid and proteases. Recent studies of patients with loss of function mutations affecting either of these processes have indicated a divergence in osteoclastic phenotypes. These difference in o
Autor:
Per Qvist, Mitsuru Koizumi, Diana Julie Leeming, Niels Lynnerup, Inger Byrjalsen, Michael Fregerslev, Morten A. Karsdal, Claus Christiansen, Mette G Sørensen
Publikováno v:
BMC Cancer, Vol 8, Iss 1, p 180 (2008)
BMC Cancer
BMC Cancer
Background Breast and prostate cancer patients often develop lesions of locally high bone turnover, when the primary tumor metastasizes to the bone causing an abnormal high bone resorption at this site. The objective of the present study was to deter
Publikováno v:
Biochemical and biophysical research communications. 360(4)
Osteoclasts are the sole cells possessing the ability to resorb calcified bone matrix. This occurs via secretion of hydrochloric acid mediated by the V-ATPase and the chloride channel ClC-7. Loss of acidification leads to osteopetrosis characterized