Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Mette Dalskov Mosgaard"'
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Akademický článek
Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
Autor: Zarmeena Abid, Mette Dalskov Mosgaard, Giorgio Manfroni, Ritika Singh Petersen, Line Hagner Nielsen, Anette Müllertz, Anja Boisen, Stephan Sylvest Keller
Publikováno v: Polymers, Vol 11, Iss 11, p 1828 (2019)
Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainer
Externí odkaz: https://doaj.org/article/48fa1370ff8e4763887273caf252c71c
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2
Management of oral biofilms by nisin delivery in adhesive microdevices
Autor: Rikke Louise Meyer, Stine Egebro Birk, Anja Boisen, Mette Dalskov Mosgaard, Line Hagner Nielsen, Rolf Bech Kjeldsen
Publikováno v: Birk, S E, Mosgaard, M D, Kjeldsen, R B, Boisen, A, Meyer, R L & Nielsen, L H 2021, ' Management of oral biofilms by nisin delivery in adhesive microdevices ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 167, pp. 83-88 . https://doi.org/10.1016/j.ejpb.2021.07.007
Numerous beneficial microbes thrive in the oral cavity where they form biofilms on dental and mucosal surfaces to get access to nutrients, and to avoid being carried away with the saliva. However, biofilm formation is also a virulence factor as it al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a29ef0c9c309417c75c87a86038383
https://doi.org/10.1016/j.ejpb.2021.07.007
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3
Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
Autor: Ritika Singh Petersen, Anja Boisen, Anette Müllertz, Stephan Sylvest Keller, Mette Dalskov Mosgaard, Zarmeena Abid, Line Hagner Nielsen, Giorgio Manfroni
Publikováno v: Abid, Z, Dalskov Mosgaard, M, Manfroni, G, Singh Petersen, R, Hagner Nielsen, L, Mullertz, A, Boisen, A & Sylvest Keller, S 2019, ' Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery ', Polymers, vol. 11, 1828 . https://doi.org/10.3390/polym11111828
Polymers, Vol 11, Iss 11, p 1828 (2019)
Polymers
Volume 11
Issue 11
Abid, Z, Mosgaard, M D, Manfroni, G, Petersen, R S, Nielsen, L H, Müllertz, A, Boisen, A & Keller, S S 2019, ' Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery ', Polymers, vol. 11, 1828 . https://doi.org/10.3390/polym11111828
Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b366d6830506796a3b5f4338980850c8
https://doi.org/10.3390/polym11111828
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4
Mucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules
Autor: Mette Dalskov Mosgaard, Jette Bredahl Jacobsen, Eva Marxen, Anne Marie Lynge Pedersen
Publikováno v: Marxen, E, Mosgaard, M D, Pedersen, A M L & Jacobsen, J 2017, ' Mucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 121, pp. 121-128 . https://doi.org/10.1016/j.ejpb.2017.09.016
The mucus layer is believed to play a part in drug permeation across the oral mucosa. Human freeze-dried saliva (HFDS) and porcine gastric mucin (PGM) was evaluated as model for mucus layer per se or in conjunction with in vitro and ex vivo buccal pe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0522c8871a432f22de57afee10b21c76
https://orbit.dtu.dk/en/publications/010d91cb-a92a-4b78-ab5a-ccbb8dba9c11
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5
Ex vivo intestinal perfusion model for investigating mucoadhesion of microcontainers
Autor: Stephan Sylvest Keller, Mette Dalskov Mosgaard, Zarmeena Abid, Anette Müllertz, Lasse Højlund Thamdrup, Alina Joukainen Andersen, Ritika Singh Petersen, Line Hagner Nielsen, Sophie Strindberg, Anja Boisen
Publikováno v: Mosgaard, M D, Strindberg, S, Abid, Z, Petersen, R S, Thamdrup, L H E, Andersen, A J, Keller, S S, Müllertz, A, Nielsen, L H & Boisen, A 2019, ' Ex vivo intestinal perfusion model for investigating mucoadhesion of microcontainers ', International Journal of Pharmaceutics, vol. 570, 118658 . https://doi.org/10.1016/j.ijpharm.2019.118658
Dalskov Mosgaard, M, Strindberg, S, Abid, Z, Singh Petersen, R, Højlund Eklund Thamdrup, L, Joukainen Andersen, A, Sylvest Keller, S, Müllertz, A, Hagner Nielsen, L & Boisen, A 2019, ' Ex vivo intestinal perfusion model for investigating mucoadhesion of microcontainers ', International Journal of Pharmaceutics, vol. 570, 118658 . https://doi.org/10.1016/j.ijpharm.2019.118658
Micro fabricated delivery systems have shown promise in increasing oral bioavailability of drugs. Micrometer-sized polymeric devices (microcontainers) have the potential to facilitate unidirectional drug release directly into the intestinal mucosa wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e726535a84ff6d996d6d1e45e540c1
https://doi.org/10.1016/j.ijpharm.2019.118658
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6
High-Throughput Lipolysis in 96-Well Plates for Rapid Screening of Lipid-Based Drug Delivery Systems
Autor: Thomas Rades, Anette Müllertz, Huiling Mu, Philip Jonas Sassene, Mette Dalskov Mosgaard
Publikováno v: Journal of pharmaceutical sciences. 106(4)
The high-throughput in vitro intestinal lipolysis model (HTP) applicable for rapid and low-scale screening of lipid-based drug delivery systems (LbDDSs) was optimized and adjusted as to be conducted in 96-well plates (HTP-96). Three different LbDDSs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af13e010950858b8f1d277f9ddd5f64
https://pubmed.ncbi.nlm.nih.gov/28057543
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7
Elucidating the Molecular Interactions Occurring during Drug Precipitation of Weak Bases from Lipid-Based Formulations: A Case Study with Cinnarizine and a Long Chain Self-Nanoemulsifying Drug Delivery System
Autor: Philip Jonas Sassene, Thomas Rades, Mette Dalskov Mosgaard, Korbinian Löbmann, Flemming H. Larsen, Anette Müllertz, Huiling Mu
Publikováno v: Molecular pharmaceutics. 12(11)
The aim of this study was to investigate if molecular interactions between the weak base cinnarizine and lipolysis products were affecting the morphology of precipitated drug formed during in vitro lipolysis. In vitro lipolysis studies of a self-nano
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ae95ec6e68eda7f371cfda49f60770
https://pubmed.ncbi.nlm.nih.gov/26393273
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8
Development of a high-throughput in vitro intestinal lipolysis model for rapid screening of lipid-based drug delivery systems
Autor: Anette Müllertz, Thomas Rades, Huiling Mu, Mette Dalskov Mosgaard, Philip Jonas Sassene
Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 94
Purpose To develop a high-throughput in vitro intestinal lipolysis (HTP) model, without any means of pH-stat-titration, to enable a fast evaluation of lipid-based drug delivery systems (LbDDS). Material and method The HTP model was compared to the tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a717c23cfe542a9dedfc33d3297c00
https://pubmed.ncbi.nlm.nih.gov/26159837
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