Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine

Autor: Mahesh Tambe, Sarah Unterberger, Mette C. Kriegbaum, Ida Vänttinen, Ezgi June Olgac, Markus Vähä-Koskela, Mika Kontro, Krister Wennerberg, Caroline A. Heckman

Publikováno v: Cell Death and Disease, Vol 15, Iss 10, Pp 1-9 (2024)

Abstract Venetoclax plus azacitidine treatment is clinically beneficial for elderly and unfit acute myeloid leukemia (AML) patients. However, the treatment is rarely curative, and relapse due to resistant disease eventually emerges. Since no current

Externí odkaz: https://doaj.org/article/763798c230da4af69fc6e0e76963425d

Helicobacter pylori Colonization Drives Urokinase Receptor (uPAR) Expression in Murine Gastric Epithelium During Early Pathogenesis

Autor: Warner Alpízar-Alpízar, Mette E. Skindersoe, Lone Rasmussen, Mette C. Kriegbaum, Ib J. Christensen, Ida K. Lund, Martin Illemann, Ole D. Laerum, Karen A. Krogfelt, Leif P. Andersen, Michael Ploug

Publikováno v: Microorganisms, Vol 8, Iss 7, p 1019 (2020)

(1) Background: Persistent Helicobacter pylori infection is the most important risk factor for gastric cancer. The urokinase receptor (uPAR) is upregulated in lesions harboring cancer invasion and inflammation. Circumstantial evidence tends to correl

Externí odkaz: https://doaj.org/article/7900885cc62f42c894a2eb8f073e1fdf

Abstract 5779: A platform utilizing high-grade serous ovarian cancer organoids for prospective patient stratification in functional precision medicine

Autor: Wojciech Senkowski, Laura Gall-Mas, Matias M. Falco, Yilin Li, Kari Lavikka, Mette C. Kriegbaum, Jaana Oikkonen, Daria Bulanova, Elin J. Pietras, Karolin Voßgröne, Yan-Jun Chen, Erdogan P. Erkan, Mia K. Høg, Ida M. Larsen, Tarja Lamminen, Katja Kaipio, Jutta Huvila, Anni Virtanen, Lars H. Engelholm, Pernille Christiansen, Eric Santoni Rugiu, Kaisa Huhtinen, Olli Carpén, Johanna Hynninen, Sampsa Hautaniemi, Anna Vähärautio, Krister Wennerberg

Publikováno v: Cancer Research. 83:5779-5779

High-grade serous ovarian cancer (HGSC) is the most prevalent and lethal ovarian cancer type. While HGSC usually responds well to primary treatment, most cases eventually relapse. Functional precision medicine - tailoring individualized treatments ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::853559906814afa3fafad35a14c34bbc
https://doi.org/10.1158/1538-7445.am2023-5779

Abstract 3069: Efficient establishment and utilization of a high-grade serous ovarian cancer organoid biobank

Autor: Wojciech Senkowski, Laura Gall Mas, Matias M. Falco, Yilin Li, Kari Lavikka, Mette C. Kriegbaum, Jaana Oikkonen, Daria Bulanova, Elin J. Pietras, Karolin Voßgröne, Erdogan P. Erkan, Terese K. Høj, Mia K. Høg, Tarja Lamminen, Katja Kaipio, Anni Virtanen, Lars H. Engelholm, Pernille Christiansen, Eric Santoni-Rugiu, Kaisa Huhtinen, Olli Carpén, Johanna Hynninen, Sampsa Hautaniemi, Anna Vähärautio, Krister Wennerberg

Publikováno v: Cancer Research. 82:3069-3069

Extensive utilization of organoids from high-grade serous ovarian carcinoma (HGSOC), the most common and lethal ovarian cancer, has been hampered by low success rates of long-term culture and scarcity of fresh tumor material. Here we present the deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d0965950091be853786692c75539727
https://doi.org/10.1158/1538-7445.am2022-3069

Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain

Autor: Shanli Chen, Yunbin Jiang, Jinyu Li, Lin Lin, Michael Ploug, Line V. Hansen, Mingdong Huang, Cai Yuan, Mette C. Kriegbaum, Henrik Gårdsvoll, Longguang Jiang

Publikováno v: International Journal of Biological Sciences
Jiang, Y, Lin, L, Chen, S, Jiang, L, Kriegbaum, M C, Gårdsvoll, H, Hansen, L V, Li, J, Ploug, M, Yuan, C & Huang, M 2020, ' Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain ', International Journal of Biological Sciences, vol. 16, no. 6, pp. 981-993 . https://doi.org/10.7150/ijbs.39919

Ly6/uPAR/α-neurotoxin domain (LU-domain) is characterized by the presence of 4-5 disulfide bonds and three flexible loops that extend from a core stacked by several conversed disulfide bonds (thus also named three-fingered protein domain). This high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc539579ecc49334c1a302b89eabe20
https://pubmed.ncbi.nlm.nih.gov/32140067