Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mette Bentsen"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract In higher organisms, individual cells respond to signals and perturbations by epigenetic regulation and transcriptional adaptation. However, in addition to shifting the expression level of individual genes, the adaptive response of cells can
Externí odkaz:
https://doaj.org/article/c782f278431b4f36bcb91e5da7120192
Autor:
Jihyun Jang, Mette Bentsen, Ye Jun Kim, Erick Kim, Vidu Garg, Chen-Leng Cai, Mario Looso, Deqiang Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Failure of proper ventricular trabeculation is often associated with congenital heart disease. Support from endocardial cells, including the secretion of extracellular matrix and growth factors is critical for trabeculation. However, it is p
Externí odkaz:
https://doaj.org/article/e8ec9ab3b18a479e8dfee5d6b7180d34
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Transcription factors (TFs) are crucial epigenetic regulators, which enable cells to dynamically adjust gene expression in response to environmental signals. Computational procedures like digital genomic footprinting on chromatin accessibili
Externí odkaz:
https://doaj.org/article/410abb5b54e641389b90ff00755559ae
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 3, Pp 568-577 (2022)
Data visualization and interactive data exploration are important aspects of illustrating complex concepts and results from analyses of omics data. A suitable visualization has to be intuitive and accessible. Web-based dashboards have become popular
Externí odkaz:
https://doaj.org/article/c82206558a77411d965f945ffe0d19b8
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4040-4051 (2022)
Cooperativity between transcription factors is important to regulate target gene expression. In particular, the binding grammar of TFs in relation to each other, as well as in the context of other genomic elements, is crucial for TF functionality. Ho
Externí odkaz:
https://doaj.org/article/0523656b6ae444aaa31659dacdc96f0c
Autor:
Mette Bentsen, Philipp Goymann, Hendrik Schultheis, Kathrin Klee, Anastasiia Petrova, René Wiegandt, Annika Fust, Jens Preussner, Carsten Kuenne, Thomas Braun, Johnny Kim, Mario Looso
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Footprinting analysis allows genome-wide investigation of transcription factor (TF) binding on chromatin. Here the authors developed a framework termed TOBIAS aimed at identifying footprints of chromatin-associated proteins from ATAC-seq accessibilit
Externí odkaz:
https://doaj.org/article/e3286bfee3c34ca8982de7e68a99c0a2
Autor:
Jihyun Jang, Mette Bentsen, Ye-Jun Kim, Erick Kim, Vidu Garg, Chen-Leng Cai, Mario Looso, Deqiang Li
BackgroundTrabeculation, a key process in early heart development, is the formation of myocardial trabecular meshwork. The failure of trabeculation often leads to embryonic lethality. Support from endocardial cells, including the secretion of extrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64378abecd6f515fa476427547e2f478
https://doi.org/10.1101/2023.04.12.536668
https://doi.org/10.1101/2023.04.12.536668
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:568-577
Data visualization and interactive data exploration are important aspects of illustrating complex concepts and results from analyses of omics data. A suitable visualization has to be intuitive and accessible. Web-based dashboards have become popular
Publikováno v:
Computational and Structural Biotechnology Journal. 20:4040-4051
Cooperativity between transcription factors is important to regulate target gene expression. In particular, the binding grammar of TFs in relation to each other, as well as in the context of other genomic elements, is crucial for TF functionality. Ho
Autor:
Arica Beisaw, Julia Dallmann, Mario Looso, Stefan Guenther, Chi-Chung Wu, Mette Bentsen, Didier Y.R. Stainier, Carsten Kuenne
Publikováno v:
Circ Res
Rationale: The adult human heart is an organ with low regenerative potential. Heart failure following acute myocardial infarction is a leading cause of death due to the inability of cardiomyocytes to proliferate and replenish lost cardiac muscle. Whi