Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells.

Autor: Pham TD; Northwestern University, Chicago, IL, United States., Metropulos AE; Northwestern University, Chicago, IL, United States., Mubin N; Northwestern University, Chicago, IL, United States., Becker JH; Northwestern University, Chicago, Illinois, United States., Shah D; Northwestern University, Feinberg School of Medicine, Chicago, IL, United States., Spaulding C; Northwestern University, Chicago, IL, United States., Shields MA; Northwestern University, Chicago, IL, United States., Bentrem DJ; Northwestern University, Chicago, IL, United States., Munshi HG; Northwestern University, Chicago, IL, United States.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20.

Diabetic ketoacidosis masked by both Euglycemia and a primary metabolic alkalosis.

Autor: Hillock MF; University of Illinois College of Medicine, Chicago, IL, United States., Jarmon C; University of Illinois College of Medicine, Chicago, IL, United States., Metropulos AE; Northwestern University Feinberg School of Medicine, Chicago, IL, United States., King R; University of Illinois College of Medicine, Chicago, IL, United States., Tchernodrinski S; University of Illinois College of Medicine, Chicago, IL, United States., Principe DR; University of Illinois College of Medicine, Chicago, IL, United States.; Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Publikováno v: Oxford medical case reports [Oxf Med Case Reports] 2024 Jul 13; Vol. 2024 (7), pp. omae071. Date of Electronic Publication: 2024 Jul 13 (Print Publication: 2024).

BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss.

Autor: Shields MA; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; The Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA., Metropulos AE; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Jesse Brown VA Medical Center, Chicago, IL, USA., Spaulding C; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Jesse Brown VA Medical Center, Chicago, IL, USA., Hirose T; Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama, Japan.; Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Ohno S; Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama, Japan., Pham TND; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; The Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA., Munshi HG; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; The Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA.; Jesse Brown VA Medical Center, Chicago, IL, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 27. Date of Electronic Publication: 2023 Sep 27.

Chromium (VI) promotes lung cancer initiation by activating EGF/ALDH1A1 signalling.

Autor: Metropulos AE; Feinberg School of Medicine, Northwestern University, Chicago IL USA., Becker JH; Department of Surgery, University of Illinois at Chicago, Chicago, IL USA., Principe DR; Medical Scientist Training Program, University of Illinois College of Medicine, Chicago, IL USA.

Publikováno v: Clinical and translational discovery [Clin Transl Discov] 2022 Dec; Vol. 2 (4). Date of Electronic Publication: 2022 Dec 14.

Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity.

Autor: Pham TN; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Jesse Brown VA Medical Center, Chicago, Illinois, USA., Spaulding C; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Jesse Brown VA Medical Center, Chicago, Illinois, USA., Shields MA; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA., Metropulos AE; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Shah DN; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Khalafalla MG; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Principe DR; Medical Scientist Training Program, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA., Bentrem DJ; Jesse Brown VA Medical Center, Chicago, Illinois, USA.; The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA.; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Munshi HG; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Jesse Brown VA Medical Center, Chicago, Illinois, USA.; The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA.

Publikováno v: JCI insight [JCI Insight] 2022 May 09; Vol. 7 (9). Date of Electronic Publication: 2022 May 09.