Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts.

Autor: Horne RI; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Metrick MA 2nd; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.; College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Man W; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Rinauro DJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Brotzakis ZF; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Chia S; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.; Bioprocessing Technology Institute, Agency of Science, Technology and Research (A*STAR), 138668, Singapore., Meisl G; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2023 Sep 06; Vol. 14 (17), pp. 3125-3131. Date of Electronic Publication: 2023 Aug 14.

Computational maturation of a single-domain antibody against Aβ42 aggregation.

Autor: Lin J; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK ps589@cam.ac.uk mv245@cam.ac.uk., Figazzolo C; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK ps589@cam.ac.uk mv245@cam.ac.uk., Metrick MA 2nd; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK ps589@cam.ac.uk mv245@cam.ac.uk., Sormanni P; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK ps589@cam.ac.uk mv245@cam.ac.uk., Vendruscolo M; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK ps589@cam.ac.uk mv245@cam.ac.uk.

Publikováno v: Chemical science [Chem Sci] 2021 Oct 07; Vol. 12 (41), pp. 13940-13948. Date of Electronic Publication: 2021 Oct 07 (Print Publication: 2021).

Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear.

Autor: Ferreira NC; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Charco JM; CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain., Plagenz J; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Orru CD; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Denkers ND; Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA., Metrick MA 2nd; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Hughson AG; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Griffin KA; Colorado Division of Parks and Wildlife, Wildlife Health Program, 4330 Laporte Avenue, Fort Collins, CO, USA., Race B; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Hoover EA; Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA., Castilla J; CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain., Nichols TA; USDA-APHIS-VS-Cervid Health Program, Fort Collins, CO, USA., Miller MW; Colorado Division of Parks and Wildlife, Wildlife Health Program, 4330 Laporte Avenue, Fort Collins, CO, USA., Caughey B; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. bcaughey@nih.gov.

Publikováno v: Scientific reports [Sci Rep] 2021 Apr 08; Vol. 11 (1), pp. 7702. Date of Electronic Publication: 2021 Apr 08.

Temporal Characterization of Prion Shedding in Secreta of White-Tailed Deer in Longitudinal Study of Chronic Wasting Disease, United States.

Autor: Denkers, Nathaniel D.¹, McNulty, Erin E.¹, Kraft, Caitlyn N.¹, Nalls, Amy V.¹, Westrich, Joseph A.¹, Hoover, Edward A.¹, Mathiason, Candace K.¹ candace.mathiason@colostate.edu

Publikováno v: Emerging Infectious Diseases. Oct2024, Vol. 30 Issue 10, p2118-2127. 10p.

4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.

Autor: Saijo E; LPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA., Metrick MA 2nd; LPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA., Koga S; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Parchi P; IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139, Bologna, Italy.; Department of Experimental Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138, Bologna, Italy., Litvan I; Department of Neurosciences, Parkinson and Other Movement Disorders Center, University of California, San Diego, CA, USA., Spina S; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Boxer A; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Rojas JC; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Galasko D; Department of Neurosciences, University of California, San Diego, CA, USA., Kraus A; LPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA., Rossi M; IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139, Bologna, Italy., Newell K; Indiana University School of Medicine, Indianapolis, IN, USA., Zanusso G; University of Verona, Verona, Italy., Grinberg LT; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.; Department of Pathology, LIM-22, University of Sao Paulo, Sao Paulo, Brazil., Seeley WW; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Ghetti B; Indiana University School of Medicine, Indianapolis, IN, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Caughey B; LPVD, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA. bcaughey@nih.gov.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2020 Jan; Vol. 139 (1), pp. 63-77. Date of Electronic Publication: 2019 Oct 16.