Zobrazeno 1 - 10 of 403 pro vyhledávání: '"Metrick C"'
1
Akademický článek
Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation.
Autor: Pfaffenbach M; Department of Medicinal Chemistry, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Bolduc PN; Department of Medicinal Chemistry, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Xin Z; Department of Medicinal Chemistry, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gao F; Department of Medicinal Chemistry, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Evans R; Department of Medicinal Chemistry, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Fang T; Department of Acute Neurology, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Chodaparambil JV; Physical Biochemistry, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Henry KL; Department of Acute Neurology, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Li P; Drug Metabolism and Pharmacokinetics, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Mathieu S; Pharmaceutical Operations & Technology, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Metrick C; Physical Biochemistry, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Vera Rebollar JA; Department of Multiple Sclerosis and Immunology, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gu RF; Chemical Biology and Proteomics, Biogen Inc., Cambridge, Massachusetts 02142, United States., Mccarl CA; Department of Multiple Sclerosis and Immunology, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Silbereis J; Department of Multiple Sclerosis and Immunology, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States., Peterson EA; Department of Medicinal Chemistry, Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 May 23; Vol. 67 (10), pp. 8383-8395. Date of Electronic Publication: 2024 May 02.
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2
Akademický článek
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.
Autor: Bolduc PN; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Pfaffenbach M; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Evans R; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Xin Z; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Henry KL; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gao F; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Fang T; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Silbereis J; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Vera Rebollar J; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Li P; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Chodaparambil JV; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Metrick C; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Peterson EA; Department of Medicinal Chemistry;Department of Multiple Sclerosis and Immunology;Drug Metabolism and Pharmacokinetics;Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Apr 26; Vol. 15 (5), pp. 714-721. Date of Electronic Publication: 2024 Apr 26 (Print Publication: 2024).
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3
Akademický článek
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N -(6-methylpyrazolo[1,5- a ]pyrimidin-3-yl)imidazo[1,2- a ]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
Autor: Evans R; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Bolduc PN; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Pfaffenbach M; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gao F; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., May-Dracka T; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Fang T; Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Hopkins BT; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Chodaparambil JV; Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Henry KL; Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Li P; Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Metrick C; Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Nelson A; Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Trapa P; Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Thomas A; Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Burkly L; Department of Acute Neurology, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Peterson EA; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 4676-4690. Date of Electronic Publication: 2024 Mar 11.
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4
Akademický článek
Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases.
Autor: Zhang, Weiwei1 (AUTHOR), Zhu, Feiqi2 (AUTHOR), Zhu, Jie1,3 (AUTHOR), Liu, Kangding1 (AUTHOR)
Publikováno v: Analytical Cellular Pathology: Cellular Oncology. 3/7/2024, Vol. 2024, p1-12. 12p.
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6
Akademický článek
A monomeric uncleaved respiratory syncytial virus F antigen retains prefusion-specific neutralizing epitopes.
Autor: Swanson KA; Novartis Vaccines, Cambridge, Massachusetts, USA., Balabanis K; Novartis Vaccines, Cambridge, Massachusetts, USA., Xie Y; Novartis Vaccines, Cambridge, Massachusetts, USA., Aggarwal Y; Novartis Vaccines, Cambridge, Massachusetts, USA., Palomo C; Centro Nacional de Microbiología and CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain., Mas V; Centro Nacional de Microbiología and CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain., Metrick C; Novartis Vaccines, Cambridge, Massachusetts, USA., Yang H; Novartis Vaccines, Cambridge, Massachusetts, USA., Shaw CA; Novartis Vaccines, Cambridge, Massachusetts, USA., Melero JA; Centro Nacional de Microbiología and CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain., Dormitzer PR; Novartis Vaccines, Cambridge, Massachusetts, USA., Carfi A; Novartis Vaccines, Cambridge, Massachusetts, USA Centro Nacional de Microbiología and CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain andrea.carfi@novartis.com.
Publikováno v: Journal of virology [J Virol] 2014 Oct; Vol. 88 (20), pp. 11802-10. Date of Electronic Publication: 2014 Jul 30.
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7
Akademický článek
Discovery and Development of CNS-Penetrant IRAK4 Inhibitors.
Autor: Stepan, Antonia F., Puleo, Thomas R.
Publikováno v: Synfacts; Aug2024, Vol. 20 Issue 8, p863-863, 1p
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8
Akademický článek
Pressurization technique: principles and impact on quality of meat and meat products.
Autor: Akhtar, Javeed1 (AUTHOR) er.jakhtar@gmail.com, Abrha, Mebrhit Gebremariam1 (AUTHOR)
Publikováno v: Food & Agricultural Immunology. Dec2022, Vol. 33 Issue 1, p264-285. 22p.
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9
Akademický článek
A New Phospholipase D from Moritella sp. JT01: Biochemical Characterization, Crystallization and Application in the Synthesis of Phosphatidic Acid.
Autor: Wang, Fanghua1 (AUTHOR), Mao, Xuejing1 (AUTHOR), Deng, Fuli1 (AUTHOR), Cui, Ruiguo1 (AUTHOR), Li, Lilang1 (AUTHOR), Liu, Siyu1 (AUTHOR), Yang, Bo2 (AUTHOR), Lan, Dongming1 (AUTHOR) dmlan@scut.edu.cn, Wang, Yonghua1 (AUTHOR) dmlan@scut.edu.cn
Publikováno v: International Journal of Molecular Sciences. Oct2022, Vol. 23 Issue 19, p11633. 15p.
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10
Akademický článek
Review: inactivation of very heat-resistant spores of Bacilus sporothermodurans by high pressure treatment combined with others treatments.
Autor: Aouadhi, Chedia1 (AUTHOR) chediaaouadhi@yahoo.fr, Al-zaban, Mayasar I.2 (AUTHOR), Alsaloom, Albandary Nasser2 (AUTHOR), Maaroufi, Abderrazak1 (AUTHOR)
Publikováno v: High Pressure Research. Jun2022, Vol. 42 Issue 2, p236-244. 9p.
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