ChemInform Abstract: Synthesis of 3′-Deoxy-2′,3′-didehydro-3′-methylthymidine. A Potential Anti-HIV Agent

Autor: Abdallah Ezzitouni, Stanislas Czernecki, Pierre Krausz

Publikováno v: ChemInform. 22

Starting from 1,2-O-isopropylidene-α-D-xylofuranose, a versatile method for the synthesis of branched 3'-deoxy-2',3'-didehydro nucleosides is described and exemplified for an analogue of 3'-deoxy-2',3'-didehydrothymidine (d4T)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5a7480f1cf07a2335b9a08d9d7c9aca
https://doi.org/10.1002/chin.199101344

Facile synthesis of 3'-O-methylthymidine and 3'-deoxythymidine and related deoxygenated thymidine derivative: a new method for selective deoxygenation of secondary hydroxy groups

Autor: Nakanishi Takeshi, Mitsuo Sekine

Publikováno v: The Journal of Organic Chemistry. 55:924-928

This paper deals with convenient syntheses of 3'-O-methylthymidine and 3'-deoxythymidine (I) which involve Ag 2 O-promoted methylation and Barton-Robins reductive deoxygenation, respectively. New methods for the regioselective 3'- and 5'-deoxygenatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e48bc78a6c9740a15c259a4f48f4729
https://doi.org/10.1021/jo00290a024

[3H]Thymidin-Einbau und DNA-Synthese bei Funaria hygrometrica

Autor: Bernd Knoop

Publikováno v: Planta. 121:75-80

Incubation of caulonema filaments of the moss Funaria hygrometrica with [(3)H]methylthymidine followed by autoradiography fails to show the real amount of DNA-synthesis. Especially nuclei of steadily growing tip cells remain unlabelled, whereas basic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b5f1d9ca5e9a132808df44eac6ba931
https://doi.org/10.1007/bf00384008

Die Synthese von

Autor: K.H. Scheit

Publikováno v: Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 119:425-426

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be0947148482922a4f700fd6a1ec6777
https://doi.org/10.1016/0005-2787(66)90205-x

Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O2-alkylthymidines in human cells.

Autor: Weerasooriya S; Department of Chemistry, University of Connecticut, Storrs, CT 06269, United States., Jasti VP; Department of Chemistry, University of Connecticut, Storrs, CT 06269, United States., Bose A; Department of Chemistry, University of Connecticut, Storrs, CT 06269, United States., Spratt TE; Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, United States., Basu AK; Department of Chemistry, University of Connecticut, Storrs, CT 06269, United States. Electronic address: ashis.basu@uconn.edu.

Publikováno v: DNA repair [DNA Repair (Amst)] 2015 Nov; Vol. 35, pp. 63-70. Date of Electronic Publication: 2015 Sep 21.