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Comparative aspects of pulmonary toxicity induced by cytotoxic agents with emphasis on lomustine, and a veterinary case report

Autor: Van Meervenne, Sofie, de Vos, Johan P, Van Ham, Luc, Bavegems, Valérie

Publikováno v: VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT

In veterinary oncology the use of the nitrosourea compound lomustine is increasing. veterinary oncologists need to be aware of the pulmonary toxicity of this drug. Because of the lack of veterinary publications on this subject, the incidence and path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______330::cb91caaf96fb1986008153e0061b8208
https://biblio.ugent.be/publication/664800/file/709510

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Akademický článek

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Chemotherapy of the transplantable acute leukemia L5222 in rats. II. With special consideration of its high sensitivity to 2-chloroethyl-nitrosoureas

Autor: Eisenbrand G, Dietrich Schmähl, W.J. Zeller

Publikováno v: Leukemia Research. 1:229-235

The acute transplantable rat leukemia L5222 is sensitive to a series of clinically established drugs. A satisfactory effect is shown by 6-mercaptopurine, vincristine and daunomycin with respect to increased survival time of treated rats compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e051e3e6ff508ba06200cbcaeca97a4
https://doi.org/10.1016/0145-2126(77)90035-2

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Klinisch-therapeutische Studie (Phase II) mit VP-16/213 und Methyl-CCNU bei Patienten mit inoperablen, rezidivierten bzw. metastasierten Karzinomen des Magen- und Darmtraktes

Autor: J.P. Obrecht, G.A. Stalder, D. Hartmann

Publikováno v: Oncology Research and Treatment. 1:201-206

Bei Patienten mit Malignomen des Magen-Darm-Kanals fuhrten wir eine Phase-II-Studie durch, bei der die Wirksamkeit der Kombination VP-16/213 und ME-CCNU gepruft wurde. Wir untersuchten 15 Patienten (3 Magenkarzinome, 12 Kolonkarzinome) in grostenteil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a827404093ad8c9f5f629c990b77689
https://doi.org/10.1159/000213952

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5FU infusion with mitomycin-C versus 5FU infusion with methyl-CCNU in the treatment of advanced colon cancer.A southwest oncology group study

Autor: Robert M. O'Bryan, Tate Thigpen, P. N. Kim, Charles A. Coltman, R. Bottomley, John D. Bonnet, Joseph D. McCracken, Carl Groppe, Frank Panettiere, Vainutis K. Vaitkevicius, Buroker T, B. Hoogstraten, Henry E. Wilson, Lance K. Heilbrun

Publikováno v: Cancer. 42:1228-1233

The Southwest Oncology Group (SWOG) in a randomized trial evaluated 5FU infusions in combination with either Mitomycin-C or Methyl-CCNU in patients with disseminated large bowel cancer. A response rate of 18% was noted on the 5FU-Mitomycin limb as co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de062e0751164d57bdbe99b1c316a36b
https://doi.org/10.1002/1097-0142(197809)42:3<1228::aid-cncr2820420330>3.0.co

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Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU vs. methyl-CCNU plus bolus weekly 5-FU.A southwest oncology group study

Autor: Vainutis K. Vaitkevicius, Laurence H. Baker, B. W. Ruffner, Edmund A. Gehan, Daniel E. Lehane, Ronald L. Stephens, Francis S. Morrison, Richard Matter, Stephen E. Jones, Talley Rw

Publikováno v: Cancer. 38:1-7

In a randomized and stratified study, 294 patients with advanced gastrointestinal cancer were treated either with 5-fluorouracil (5-FU) 400 mg/m2 weekly intravenously (i.v.) or 5-FU 400 mg/m2 i.v. weekly plus methyl-CCNU 175 mg/m2 orally (p.o.) every

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caa450728c9a1ade213175805d75f71d
https://doi.org/10.1002/1097-0142(197607)38:1<1::aid-cncr2820380102>3.0.co

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Lack of effectiveness of combined 5-fluorouracil and methyl-ccnu therapy in advanced colorectal cancer

Autor: Robert J. Mayer, Emil Frei, Arthur T. Skarin, Jacob J. Lokich

Publikováno v: Cancer. 40:2792-2796

Fifty-two patients with advanced colorectal cancer were treated with a combination of 5-Fluorouracil (FU) plus methyl-1,3-cis (2-chlorethyl)-1-nitrosourea (MeCCNU). The treatment schedule program consisted of 5-FU, 300 mg/m2 i.v. bolus, daily for 5 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::066f0e1ec88052b3f5c42d2b636814f7
https://doi.org/10.1002/1097-0142(197712)40:6<2792::aid-cncr2820400606>3.0.co

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Nitrosourea Combination Chemotherapy: 1-(2-Chloroethyl)-3-(4-Methyl Cyclohexyl)-1 –Nitrosourea (Methyl-CCNU) and Cyclophosphamide

Autor: Jacob J. Lokich, Arthur T. Skarin

Publikováno v: Oncology. 32:169-174

MCCNU and cyclophosphamide are synergistic in animal tumor systems and have different chronology patterns for dose-limiting myelosuppression. The combination was employed in 49 patients with metastatic cancer with each drug administered on successive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2298e0693999bc49a7f4739aaae413
https://doi.org/10.1159/000225063

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