Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines

Autor: Gabriela García-Cerón, Alba Fernanda Solano-González, Iván Hazael Bello-Cortés, Ileana Andrea Bonilla-Brunner, Daniela Araiza-Olivera, Manuel Gutiérrez-Aguilar, Yazmin Ramiro-Cortés, Marcos Francisco Rosetti, Roeb García-Arrazola

Publikováno v: All Life, Vol 17, Iss 1 (2024)

In the present study, in vitro neuronal cell cultures were exposed to the two most common varieties of EDCs reported in food, phthalates and bisphenol A (BPA). Specifically, Bis (2-ethylhexyl) phthalate (DEHP), Mono-butyl-phthalate (MBP), Di-n-octylp

Externí odkaz: https://doaj.org/article/7330a954408f48edbaa391b4f068b096

A new foe in folate metabolism

Autor: Wai Leong Tam, Zhengwei Wu

Publikováno v: Nature Metabolism. 3:1436-1438

Two studies unmask the essentiality of methionine synthase activity in powering the folate cycle to replenish the tetrahydrofolate pool from 5-methyltetrahydrofolate; this generates nucleotides that support tumour growth. Dietary manipulation alters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ee7de1a2aa48379adc64d6b2ee0e986
https://doi.org/10.1038/s42255-021-00474-9

Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B 12 metabolism

Autor: David Coelho, Jean-Louis Guéant, Viola J Kosgei, Rosa-Maria Guéant-Rodriguez

Publikováno v: Critical Reviews in Biochemistry and Molecular Biology
Critical Reviews in Biochemistry and Molecular Biology, Taylor & Francis, 2021, pp.1-23. ⟨10.1080/10409238.2021.1979459⟩

International audience; Methyl-Cobalamin (Cbl) derives from dietary vitamin B12 and acts as a cofactor of methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of homocysteine to generate methionine and tetrahydrofolate,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b8122971420f510a5de9f85c1b037e
https://hal.univ-lorraine.fr/hal-03411928

Effect of methylcobalamin-C-10-Br from stinky tofu on inhibition of Listeria monocytogenes and alteration of microbiota in an in vitro colonic simulation

Autor: Shi Lihua, Chen Jie, Yalin Zhang, Xiaoming Su, Xuan Zhu, Shasha Xiang, Yin Ge, Haoying Han, Sheng Fang, Yanting Xia, Yiqing Zheng

Publikováno v: LWT. 153:112472

In this study, it was found that methylcobalamin-C-10-Br (MeCbl-C-10-Br) from stinky tofu exerts an inhibitory effect on Listeria monocytogenes, and the minimum inhibitory concentration was 0.125 ng/mL. Here, we studied the effect of MeCbl-C-10-Br on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffb530986728c70767be107537913d4e
https://doi.org/10.1016/j.lwt.2021.112472

Intractable Epilepsy due to MTR Deficiency: Importance of Homocysteine Analysis

Autor: Jonna Komulainen-Ebrahim, Heli Helander, Elisa Rahikkala, Leila Risteli, Reetta Hinttala, Johanna Uusimaa, Heikki Rantala, Eemeli Saastamoinen

Publikováno v: Neuropediatrics. 48(6)

Background Methionine synthase deficiency is a rare inborn error of intracellular cobalamin metabolism caused by mutations in the MTR (5-methyltetrahydrofolate-homocysteine S-methyltransferase) gene, resulting in megaloblastic anemia and neurologic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10104442f530f1fc0d21edbd15d84fc0
https://pubmed.ncbi.nlm.nih.gov/28666289