RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression

Autor: Stuart W. McKellar, Ivayla Ivanova, Pedro Arede, Rachel L. Zapf, Noémie Mercier, Liang-Cui Chu, Daniel G. Mediati, Amy C. Pickering, Paul Briaud, Robert G. Foster, Grzegorz Kudla, J. Ross Fitzgerald, Isabelle Caldelari, Ronan K. Carroll, Jai J. Tree, Sander Granneman

Publikováno v: McKellar, S W, Ivanova, I, Arede, P, Zapf, R L, Mercier, N, Chu, L-C, Mediati, D G, Pickering, A C, Briaud, P, Foster, R G, Kudla, G, Ross Fitzgerald, J, Caldelari, I, Carroll, R K, Tree, J J & Granneman, S 2022, ' RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression ', Nature Communications, vol. 13, no. 1, 3560, pp. 1-20 . https://doi.org/10.1038/s41467-022-31173-y

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen responsible for significant human morbidity and mortality. Post-transcriptional regulation by small RNAs (sRNAs) has emerged as an important mechanism for controlling virulenc

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Emergence of methicillin resistance predates the clinical use of antibiotics

Autor: Jesper Larsen, Claire L. Raisen, Xiaoliang Ba, Nicholas J. Sadgrove, Guillermo F. Padilla-González, Monique S. J. Simmonds, Igor Loncaric, Heidrun Kerschner, Petra Apfalter, Rainer Hartl, Ariane Deplano, Stien Vandendriessche, Barbora Černá Bolfíková, Pavel Hulva, Maiken C. Arendrup, Rasmus K. Hare, Céline Barnadas, Marc Stegger, Raphael N. Sieber, Robert L. Skov, Andreas Petersen, Øystein Angen, Sophie L. Rasmussen, Carmen Espinosa-Gongora, Frank M. Aarestrup, Laura J. Lindholm, Suvi M. Nykäsenoja, Frederic Laurent, Karsten Becker, Birgit Walther, Corinna Kehrenberg, Christiane Cuny, Franziska Layer, Guido Werner, Wolfgang Witte, Ivonne Stamm, Paolo Moroni, Hannah J. Jørgensen, Hermínia de Lencastre, Emilia Cercenado, Fernando García-Garrote, Stefan Börjesson, Sara Hæggman, Vincent Perreten, Christopher J. Teale, Andrew S. Waller, Bruno Pichon, Martin D. Curran, Matthew J. Ellington, John J. Welch, Sharon J. Peacock, David J. Seilly, Fiona J. E. Morgan, Julian Parkhill, Nazreen F. Hadjirin, Jodi A. Lindsay, Matthew T. G. Holden, Giles F. Edwards, Geoffrey Foster, Gavin K. Paterson, Xavier Didelot, Mark A. Holmes, Ewan M. Harrison, Anders R. Larsen

Publikováno v: Larsen, Jesper; Raisen, Claire L; Ba, Xiaoliang; Sadgrove, Nicholas J; Padilla-González, Guillermo F; Simmonds, Monique S J; Loncaric, Igor; Kerschner, Heidrun; Apfalter, Petra; Hartl, Rainer; Deplano, Ariane; Vandendriessche, Stien; Černá Bolfíková, Barbora; Hulva, Pavel; Arendrup, Maiken C; Hare, Rasmus K; Barnadas, Céline; Stegger, Marc; Sieber, Raphael N; Skov, Robert L; ... (2022). Emergence of methicillin resistance predates the clinical use of antibiotics. Nature, 602(7895), pp. 135-141. Springer Nature Limited 10.1038/s41586-021-04265-w
Larsen, J, Raisen, C L, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Ariane Deplano, A, Vandendriessche, S, Bolfíková, B Č, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L, Nykäsenoja, S, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, J. Teale, C, Waller, A, Pichon, B, Curran, M, Ellington, M, Welch, J, Peacock, S, Seilly, D, Morgan, F, Parkhill, J, Hadjirin, N, Lindsay, J, Holden, M T G, Edwards, G F, Foster, G, Paterson, G, Didelot, X, Holmes, M, Harrison, E & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, no. 7895, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-w
Larsen, J, Raisen, C L, Ba, X, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Deplano, A, Vandendriessche, S, Černá Bolfíková, B, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L J, Nykäsenoja, S M, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H J, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, Teale, C J, Waller, A S, Pichon, B, Curran, M D, Ellington, M J, Welch, J J, Peacock, S J, Seilly, D J, Morgan, F J E, Parkhill, J, Hadjirin, N F, Lindsay, J A, Holden, M T G, Edwards, G F, Foster, G, Paterson, G K, Didelot, X, Holmes, M A, Harrison, E M & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135–141 . https://doi.org/10.1038/s41586-021-04265-w
Paterson, G K 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-w

X.D. was funded by a grant from the National Institute for Health Research (NIHR) Health Protection Research Unit in Genomics and Enabling Data (no. NIHR200892). M.A.H. was supported by grants from the Medical Research Council (nos. G1001787/1, MR/N0

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Evolution and Population Dynamics of Clonal Complex 152 Community-Associated Methicillin-Resistant Staphylococcus aureus

Autor: Aina Elisabeth Fossum Moen, Marc Stegger, Paal Skytt Andersen, Ivana Cirkovic, Frieder Schaumburg, Frédéric Laurent, Berit Lilje, Graeme R. Nimmo, Patricia Martins Simoes, Anne Tristan, Sara Mernelius, Sharmin Baig, Thor Bech Johannesen, Michael Z. David, Dominique S. Blanc, Anders Rhod Larsen, Iris Spiliopoulou, Beverly Egyir

Publikováno v: Baig, S, Rhod Larsen, A, Martins Simões, P, Laurent, F, Johannesen, T B, Lilje, B, Tristan, A, Schaumburg, F, Egyir, B, Cirkovic, I, Nimmo, G R, Spiliopoulou, I, Blanc, D S, Mernelius, S, Moen, A E F, David, M Z, Andersen, P S & Stegger, M 2020, ' Evolution and Population Dynamics of Clonal Complex 152 Community-Associated Methicillin-Resistant Staphylococcus aureus ', mSphere, vol. 5, no. 4, e00226-20 . https://doi.org/10.1128/mSphere.00226-20
mSphere, vol. 5, no. 4, pp. e00226-20
mSphere, Vol 5, Iss 4, p e00226-20 (2020)
mSphere, Vol 5, Iss 4 (2020)

Since the late 1990s, changes in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) were recognized with the emergence of community-associated MRSA (CA-MRSA). CA-MRSA belonging to clonal complex 152 (CC152), carrying the small sta

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https://doi.org/10.1128/msphere.00226-20

Concentration of Airborne Staphylococcus aureus (MRSA and MSSA), Total Bacteria, and Endotoxins in Pig Farms

Autor: Masclaux, Frédéric G., Sakwinska, Olga, Charrière, Nicole, Semaani, Eulalia, Oppliger, Anne

Publikováno v: The Annals of Occupational Hygiene, vol. 57, no. 5, pp. 550-557

Pigs are very often colonized by Staphylococcus aureus and transmission of such pig-associated S. aureus to humans can cause serious medical, hygiene, and economic problems. The transmission route of zoonotic pathogens colonizing farm animals to huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4d4f9e5a7fd36f1d5dfd82eabf0e4ea0
http://doc.rero.ch/record/290912/files/mes098.pdf

Emergence of livestock-associated methicillin-resistant Staphylococcus aureus bloodstream infections in Denmark

Autor: Larsen, Jesper, Petersen, Andreas, Larsen, Anders R, Sieber, Raphael N, Stegger, Marc, Koch, Anders, Aarestrup, Frank M, Price, Lance B, Skov, Robert L, Ripadal, Pernille

Publikováno v: Larsen, J, Petersen, A, Larsen, A R, Sieber, R N, Stegger, M, Koch, A, Aarestrup, F M, Price, L B, Skov, R L, Danish MRSA Study Group & Ripadal, P 2017, ' Emergence of livestock-associated methicillin-resistant Staphylococcus aureus bloodstream infections in Denmark ', Clinical Infectious Diseases, vol. 65, no. 7, pp. 1072-1076 . https://doi.org/10.1093/cid/cix504
Danish MRSA Study Group 2017, ' Emergence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Denmark ', Clinical Infectious Diseases, vol. 65, no. 7, pp. 1072-1076 . https://doi.org/10.1093/cid/cix504
Larsen, J, Petersen, A, Larsen, A R, Sieber, R N, Stegger, M, Koch, A, Aarestrup, F M, Price, L B, Skov, R L & Grp, D MRSA S 2017, ' Emergence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Denmark ', Clinical Infectious Diseases, vol. 65, no. 7, pp. 1072-1076 . https://doi.org/10.1093/cid/cix504
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

Summary Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) CC398 was an increasing cause of bacteremia in Denmark during 2010–2015. Most patients lived in rural areas but had no contact to livestock. Whole-genome sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a8cadaf47bffbe1a72899f171c7553
https://vbn.aau.dk/da/publications/1823c791-6809-4874-b9c7-78dca847159b