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pro vyhledávání: '"Methajit Methawasin"'
Akademický článek
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Akademický článek
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Autor:
Caiying Guo, Henk Granzier, Charles S. Chung, Kirk R. Hutchinson, Nathan E. Cromer, Methajit Methawasin, Xiuju Luo
Publikováno v:
Biophysical Journal. 102(3)
Titin is a giant protein that functions as a molecular spring and contributes to the passive diastolic stiffness of the left ventricle (LV). Titin's spring region consists of three sequence elements: the tandem Ig, the N2B and the PEVK elements. Mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cd6018f19c79bfe6e4230130515ca1
Autor:
Carlos Hidalgo, Charles S. Chung, O. Lynne Nelson, Michael Gotthardt, Methajit Methawasin, Michael H. Radke, Henk Granzier
Viscosity is proposed to modulate diastolic function, but only limited understanding of the source(s) of viscosity exists. In vitro experiments have shown that the proline-glutamic acid-valine-lysine (PEVK) rich element of titin interacts with actin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31536098c3cfd76dbba88719a4099e4b
https://europepmc.org/articles/PMC3150406/
https://europepmc.org/articles/PMC3150406/
Autor:
Joshua Nedrud, Methajit Methawasin, Henk Granzier, Nicholas M.P. King, Charles S. Chung, Michiel Helmes
Publikováno v:
Biophysical Journal. 100(3)
We investigated the contribution of actomyosin interactions in unactivated intact and skinned cardiomyocytes in physiologic conditions.A carbon fiber based cell-attachment system was used to measure the diastolic stress-sarcomere length (SL) relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2693380ab665951552941125ea343a28
Publikováno v:
Biophysical Journal. 102:559a
Titin is widely considered the main contributor to passive stiffness of cardiac myocytes. To test this we studied a novel mouse model, in which a large fraction of titin's proximal tandem Ig segment is deleted (we refer to the model as IG KO; for det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e179a8ec448bc52dd0230f72d5f3a58f
https://doi.org/10.1016/j.bpj.2011.11.3044
https://doi.org/10.1016/j.bpj.2011.11.3044
Quantification of Titin Based Viscosity: Temperature, Lattice Compression and Integrative Physiology
Publikováno v:
Biophysical Journal. 100:455a
Viscosity is proposed to modulate diastolic function, but there is only limited understanding of the source(s) of viscosity. In-vitro experiments have shown that the proline-glutamic acid-valine-lysine (PEVK) rich element of titin binds actin, causin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c967aee06f6007dc795ac4f1b2c3e648
https://doi.org/10.1016/j.bpj.2010.12.2679
https://doi.org/10.1016/j.bpj.2010.12.2679
Autor:
Michael Gotthardt, O. Lynne Nelson, Charles S. Chung, Henk Granzier, Joseph Popper, Methajit Methawasin
Publikováno v:
Biophysical Journal. 98:553a
Viscosity has recently been hypothesized as an important regulator of diastolic relaxation during isovolumic relaxation and early rapid filling. A viscous interaction between the proline-glutamic acid-valine-lysine (PEVK) rich region of titin and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e2b93a6351ae067c2539a532dcd163
https://doi.org/10.1016/j.bpj.2009.12.2995
https://doi.org/10.1016/j.bpj.2009.12.2995