Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Mete Civelek"'
Publikováno v:
eLife, Vol 12 (2023)
Obesity is a major risk factor for cardiovascular disease, stroke, and type 2 diabetes (T2D). Excessive accumulation of fat in the abdomen further increases T2D risk. Abdominal obesity is measured by calculating the ratio of waist-to-hip circumferenc
Externí odkaz:
https://doaj.org/article/20e27820d0774e8690b2a51b450d67cf
Publikováno v:
HGG Advances, Vol 4, Iss 1, Pp 100164- (2023)
Summary: Circular RNAs (circRNAs) are a class of non-coding RNAs that have cell-type-specific expression and are relevant in cardiovascular disease. Aortic smooth muscle cells (SMCs) play a crucial role in cardiovascular disease. In this study, we em
Externí odkaz:
https://doaj.org/article/0d6a678d5085437c8014a2d7281f5347
Autor:
Mete Civelek, Alan M. Fogelman, Catherine C. Hedrick, Aldons J. Lusis, Casey E. Romanoski, Joseph L. Witztum
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 4, Pp 100180- (2022)
Externí odkaz:
https://doaj.org/article/9195fa147a91497c9578e36c6dc5e092
Autor:
Iina Tuominen, Brie K. Fuqua, Calvin Pan, Nicole Renaud, Kevin Wroblewski, Mete Civelek, Kara Clerkin, Ashot Asaryan, Sara G. Haroutunian, Joseph Loureiro, Jason Borawski, Guglielmo Roma, Judith Knehr, Walter Carbone, Samuel French, Brian W. Parks, Simon T. Hui, Margarete Mehrabian, Clara Magyar, Rita M. Cantor, Chinweike Ukomadu, Aldons J. Lusis, Simon W. Beaven
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 199-220 (2021)
Background & Aims: Liver fibrosis is a multifactorial trait that develops in response to chronic liver injury. Our aim was to characterize the genetic architecture of carbon tetrachloride (CCl4)-induced liver fibrosis using the Hybrid Mouse Diversity
Externí odkaz:
https://doaj.org/article/805a57b68c664391ba2c3054c6d2c50d
Autor:
Wenfan Ke, Jordan N Reed, Chenyu Yang, Noel Higgason, Leila Rayyan, Carolina Wählby, Anne E Carpenter, Mete Civelek, Eyleen J O'Rourke
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009736 (2021)
Obesity and its associated metabolic syndrome are a leading cause of morbidity and mortality. Given the disease's heavy burden on patients and the healthcare system, there has been increased interest in identifying pharmacological targets for the tre
Externí odkaz:
https://doaj.org/article/ca9c57c357704cf4bc78b298a45d7a47
Autor:
Qianyi Yang, Mete Civelek
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Metabolic syndrome (MetSyn) is a combination of metabolic abnormalities that lead to the development of cardiovascular disease (CVD) and Type 2 Diabetes (T2D). Although various criteria for defining MetSyn exist, common abnormalities include abdomina
Externí odkaz:
https://doaj.org/article/ec8917b55f674a2f99abc63f2c7b11f1
Autor:
Robert N Helsley, Venkateshwari Varadharajan, Amanda L Brown, Anthony D Gromovsky, Rebecca C Schugar, Iyappan Ramachandiran, Kevin Fung, Mohammad Nasser Kabbany, Rakhee Banerjee, Chase K Neumann, Chelsea Finney, Preeti Pathak, Danny Orabi, Lucas J Osborn, William Massey, Renliang Zhang, Anagha Kadam, Brian E Sansbury, Calvin Pan, Jessica Sacks, Richard G Lee, Rosanne M Crooke, Mark J Graham, Madeleine E Lemieux, Valentin Gogonea, John P Kirwan, Daniela S Allende, Mete Civelek, Paul L Fox, Lawrence L Rudel, Aldons J Lusis, Matthew Spite, J Mark Brown
Publikováno v:
eLife, Vol 8 (2019)
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane channel-like 4 (TMC4) that associate with increased risk of non-alcoholic fatty liver di
Externí odkaz:
https://doaj.org/article/f9448bea0b9e426ea0147da3a9110b3e
Autor:
David Z. Pan, Kristina M. Garske, Marcus Alvarez, Yash V. Bhagat, James Boocock, Elina Nikkola, Zong Miao, Chelsea K. Raulerson, Rita M. Cantor, Mete Civelek, Craig A. Glastonbury, Kerrin S. Small, Michael Boehnke, Aldons J. Lusis, Janet S. Sinsheimer, Karen L. Mohlke, Markku Laakso, Päivi Pajukanta, Arthur Ko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
GWAS have identified numerous genetic loci for BMI and related traits. Here, Pan et al. generate Promoter Capture Hi-C data for human white adipocytes and integrate these with data of transcription factor motifs, RNA-seq and GWAS to identify eQTL-eGe
Externí odkaz:
https://doaj.org/article/133629e0a6304f2f8d3499574a04d269
Autor:
Maren E. Cannon, Qing Duan, Ying Wu, Monica Zeynalzadeh, Zheng Xu, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Mete Civelek, Aldons J. Lusis, Johanna Kuusisto, Francis S. Collins, Michael Boehnke, Hua Tang, Markku Laakso, Yun Li, Karen L. Mohlke
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 3217-3227 (2017)
Recent genome-wide association studies (GWAS) have identified variants associated with high-density lipoprotein cholesterol (HDL-C) located in or near the ANGPTL8 gene. Given the extensive sharing of GWAS loci across populations, we hypothesized that
Externí odkaz:
https://doaj.org/article/ecc7f25e27af4436b24b3848b1791633
Autor:
Rebecca C. Schugar, Diana M. Shih, Manya Warrier, Robert N. Helsley, Amy Burrows, Daniel Ferguson, Amanda L. Brown, Anthony D. Gromovsky, Markus Heine, Arunachal Chatterjee, Lin Li, Xinmin S. Li, Zeneng Wang, Belinda Willard, YongHong Meng, Hanjun Kim, Nam Che, Calvin Pan, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Richard E. Morton, Carl D. Langefeld, Swapan K. Das, Lawrence L. Rudel, Nizar Zein, Arthur J. McCullough, Srinivasan Dasarathy, W.H. Wilson Tang, Bernadette O. Erokwu, Chris A. Flask, Markku Laakso, Mete Civelek, Sathyamangla V. Naga Prasad, Joerg Heeren, Aldons J. Lusis, Stanley L. Hazen, J. Mark Brown
Publikováno v:
Cell Reports, Vol 19, Iss 12, Pp 2451-2461 (2017)
Summary: Emerging evidence suggests that microbes resident in the human intestine represent a key environmental factor contributing to obesity-associated disorders. Here, we demonstrate that the gut microbiota-initiated trimethylamine N-oxide (TMAO)-
Externí odkaz:
https://doaj.org/article/29084d33ab134b3ea3fa102f1e392396