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Akademický článek

Demonstration of relative bioavailability of newly developed and innovator drug metaxalone 800 mg in healthy subjects under fed condition

Autor: Socorrina Colaco, N Ramesh, Ramakrishna Shabaraya

Publikováno v: Journal of Advanced Pharmaceutical Technology & Research, Vol 13, Iss 2, Pp 123-127 (2022)

The notable unbiased of this research work was to evaluate the well-being and effectiveness of metaxalone by administering the newly developed test and reference drug. A two-period, two-categorization, crossover bioavailability study in fed condition

Externí odkaz: https://doaj.org/article/eb3fe1e1cd824d4bad8598b242ff8445

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Akademický článek

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Akademický článek

Quantitative determination of metaxalone in human plasma by LC-MS and its application in a pharmacokinetic study

Autor: Lanting Zhao, Qian Li, Chang Shu, Keli Wang, Li Ding

Publikováno v: Asian Journal of Pharmaceutical Sciences, Vol 11, Iss 5, Pp 668-672 (2016)

A simple and rapid method using liquid chromatography–mass spectrometry (LC-MS) for the determination of metaxalone in human plasma has been developed and validated. Letrozole was used as the internal standard (IS). The plasma samples were simply t

Externí odkaz: https://doaj.org/article/1b4e3b591bd840b79d6d27776026e2df

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Akademický článek

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MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells

Autor: Francesco Squadrito, Giovanni Pallio, Luigi Cardia, Giacomo Picciolo, Domenica Altavilla, Letteria Minutoli, Alessandra Bitto, Natasha Irrera, Angela D'Ascola, Federica Mannino, Violetta Squadrito

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8425, p 8425 (2021)

Experimental and clinical studies have suggested that several neurological disorders are associated with the occurrence of central nervous system neuroinflammation. Metaxalone is an FDA-approved muscle relaxant that has been reported to inhibit monoa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e31f9c8a808e1a431212172c361d69

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Metaxalone Suppresses Production of Inflammatory Cytokines Associated with Painful Conditions in Mouse Macrophages RAW264.7 Cells in Vitro: Synergistic Effect with β-caryophyllene

Autor: Robert M. Levy, Masayoshi Yamaguchi

Publikováno v: Current Molecular Medicine. 20:643-652

Backgrounds and Objective: Inflammation is implicated in the pathogenesis of many diseases. Inflammatory cytokines with painful conditions are well known as biomarkers in human muscle pain, and they are produced by macrophages. Metaxalone is used as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7afe4532d9bb27244e69f7ca93e6aa3
https://doi.org/10.2174/1566524020666200217102508

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Chirality-dependent supramolecular synthons based on the 1,3-oxazolidin-2-one framework: chiral drugs mephenoxalone, metaxalone and 114 other examples

Autor: Alexander A. Bredikhin, Aidar T. Gubaidullin, Zemfira A. Bredikhina

Publikováno v: CrystEngComm. 22:7252-7261

In four of the five crystalline modifications of the muscle relaxants mephenoxalone 3 and metaxalone 2, chain supramolecular motifs of three different types are realized. The centrosymmetric cyclic dimer, which is considered typical of amides, was fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62568343b3abd98728dace39e885714e
https://doi.org/10.1039/d0ce00116c

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Isostructural cocrystals of metaxalone with improved dissolution characteristics

Autor: Sunil Kumar Vinubhai Gohel, Girij Pal Singh, Vasanthi Palanisamy, Palash Sanphui, Vladimir V. Chernyshev, Muthuramalingam Prakash

Publikováno v: RSC advances. 11(49)

Muscle relaxant and pain reliever metaxalone (MET) is a biopharmaceutical classification systems (BCS) class II drug with poor aqueous solubility and high permeability. The presence of an aromatic skeleton and cyclic carboxamate moiety are the probab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a9ec79ba9ca1de1fdc300f715a966a
https://pubmed.ncbi.nlm.nih.gov/35479860

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A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain

Autor: Clemencia Solorzano, E. John Gallagher, Michael P. Jones, Purvi D. Shah, Eleftheria Zias, Andrew Wollowitz, Scott Pearlman, Benjamin W. Friedman, Eddie Irizarry

Publikováno v: Ann Emerg Med

Study objective Patients with low back pain are often treated with nonsteroidal anti-inflammatory drugs and skeletal muscle relaxants. We compare functional outcomes and pain among patients with acute low back pain who were randomized to a 1-week cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc52b0dadb67a6bc851b5b7d86afb95
https://doi.org/10.1016/j.annemergmed.2019.02.017

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