Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

Autor: Green, CR, Wallace, M, Divakaruni, AS, Phillips, SA, Murphy, AN, Ciaraldi, TP, Metallo, CM

Publikováno v: Nature chemical biology, vol 12, iss 1
Green, CR; Wallace, M; Divakaruni, AS; Phillips, SA; Murphy, AN; Ciaraldi, TP; et al.(2016). Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. Nature Chemical Biology, 12(1), 15-21. doi: 10.1038/nchembio.1961. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5hd6t56w
Nature Chemical Biology, vol 12, iss 1

Adipose tissue plays important roles in regulating carbohydrate and lipid homeostasis, but less is known about the regulation of amino acid metabolism in adipocytes. Here we applied isotope tracing to pre-adipocytes and differentiated adipocytes to q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::331b77c20804fc03953f2fc74e7c9e70
https://escholarship.org/uc/item/6zd459ds

Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (vol 56, pg 425, 2014)

Autor: Vacanti, NM, Divakaruni, AS, Green, CR, Parker, SJ, Henry, RR, Ciaraldi, TP, Murphy, AN, Metallo, CM

Publikováno v: MOLECULAR CELL, vol 56, iss 5
Vacanti, NM; Divakaruni, AS; Green, CR; Parker, SJ; Henry, RR; Ciaraldi, TP; et al.(2014). Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (vol 56, pg 425, 2014). MOLECULAR CELL, 56(5), 717-717. doi: 10.1016/j.molcel.2014.11.017. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6j0659p4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::41d5887439b5670e1079a70a25910560
https://escholarship.org/uc/item/6j0659p4

Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis.

Autor: Gengatharan JM; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Handzlik MK; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Chih ZY; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Ruchhoeft ML; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Secrest P; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Ashley EL; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Green CR; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Wallace M; School of Agriculture and Food Science, University College Dublin, Dublin, Ireland., Gordts PLSM; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA., Metallo CM; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. Electronic address: metallo@salk.edu.

Publikováno v: Cell metabolism [Cell Metab] 2024 Nov 13. Date of Electronic Publication: 2024 Nov 13.

Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase.

Autor: Liu JY; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Kuna RS; Department of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA., Pinheiro LV; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Nguyen PTT; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Welles JE; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Drummond JM; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA., Murali N; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA., Sharma PV; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Supplee JG; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Shiue M; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA., Zhao S; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Farria AT; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA., Kumar A; Department of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA., Ruchhoeft ML; Department of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA., Demetriadou C; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Kantner DS; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Chatoff A; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Megill E; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Titchenell PM; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Snyder NW; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Metallo CM; Department of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: metallo@salk.edu., Wellen KE; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: wellenk@upenn.edu.

Publikováno v: Cell metabolism [Cell Metab] 2024 Oct 28. Date of Electronic Publication: 2024 Oct 28.

Modeling compound lipid homeostasis using stable isotope tracing.

Autor: Wessendorf-Rodriguez K, Ruchhoeft ML, Ashley EL, Galvez HM, Murray CW, McGregor G, Kambhampati S, Shaw RJ, Metallo CM

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.