Zobrazeno 1 - 10 of 71 pro vyhledávání: '"Metabolic window"'
1
Abaloparatide, the second generation osteoanabolic drug: Molecular mechanisms underlying its advantages over the first-in-class teriparatide
Autor: Subhashis Pal, Naibedya Chattopadhyay, Sharmistha Bhattacharyya
Publikováno v: Biochemical Pharmacology. 166:185-191
Abaloparatide is an analog of human parathyroid hormone-related protein (PTHrP) that has recently been approved for the treatment of post-menopausal osteoporosis. Abaloparatide is a stimulator of bone formation similar to teriparatide (1-34 PTH/TPTD)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05ca31a520e634bc355c97aa3bb8d07
https://doi.org/10.1016/j.bcp.2019.05.024
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2
Osteoporosis treatment with anti-sclerostin antibodies-mechanisms of action and clinical application
Autor: Elena Tsourdi, Hanna Taipaleenmäki, Elizabeth M. Winter, Martina Rauner
Publikováno v: Journal of Clinical Medicine, 10(4). MDPI
Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 10, Iss 787, p 787 (2021)
Osteoporosis is characterized by reduced bone mass and disruption of bone architecture, resulting in increased risk of fragility fractures and significant long-term disability. Although both anti-resorptive treatments and osteoanabolic drugs, such as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e44d50dc3507af4f7115afc5cdda83
https://hdl.handle.net/1887/3237882
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3
PTH and PTHrP Analogs: Treatment of Osteoporosis
Autor: John P. Bilezikian, Gaia Tabacco
Publikováno v: Osteoporosis ISBN: 9783319692869
Until 2002, antiresorptive agents defined our pharmacological approach to osteoporosis. With the introduction of teriparatide, PTH (1-34), and, more recently abaloparatide, PTHrP (1-34), as treatments for osteoporosis, we now have available a class o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6305b0b660796aecccc76eb6137523d
https://doi.org/10.1007/978-3-319-69287-6_17
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5
Sarcopenia: Causes and Treatments
Autor: H Wackerhage
Publikováno v: Deutsche Zeitschrift für Sportmedizin. 2017:178-184
››Low birth rates and increased life expectancies have led to population aging e.g. in Japan and Europe. Aging is a time-dependent functional decline that affects most living organisms. ››The loss of muscle mass and function during normal agi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0900fc23a978accc1adcb5f7fe01cd45
https://doi.org/10.5960/dzsm.2017.289
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6
Is There a Postworkout Anabolic Window of Opportunity for Nutrient Consumption? Clearing up Controversies
Autor: Brad J. Schoenfeld, Alan A. Aragon
Publikováno v: The Journal of orthopaedic and sports physical therapy. 48(12)
Nutrient timing is a popular strategy for enhancing muscular adaptations and athletic performance. From the standpoint of muscle hypertrophy, the concept of a "postworkout anabolic window of opportunity" has been proposed, whereby a limited time exis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ceb34906bc559b8df8e20691688058
https://pubmed.ncbi.nlm.nih.gov/30702982
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7
Frequent administration of abaloparatide shows greater gains in bone anabolic window and bone mineral density in mice: A comparison with teriparatide
Autor: Yoshimasa Takahashi, Tomoka Hasegawa, Hideko Takagi, Norio Amizuka, Akito Makino, Naoki Hase
Publikováno v: Bone. 142:115651
Abaloparatide (ABL) is a novel 34-amino acid peptide analog of parathyroid hormone-related protein. In clinical studies, although ABL showed a greater bone mineral density (BMD) increase than teriparatide (TPTD, human parathyroid hormone 1–34), the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff112b8e538207516fe36b5c3d58b2b0
https://doi.org/10.1016/j.bone.2020.115651
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8
Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: A pilot study
Autor: Eric M. Bluman, Elizabeth Matzkin, Bharti Khurana, Jennifer Baima, Shelley Hurwitz, Christopher P. Chiodo, Meryl S. LeBoff, Lisa Y. Chi, Ellen A. Almirol
Publikováno v: Journal of Clinical & Translational Endocrinology
Journal of Clinical & Translational Endocrinology, Vol 5, Iss C, Pp 7-14 (2016)
Highlights • Teriparatide (TPTD) and fracture healing studies in premenopausal women is limited. • Brief TPTD administration showed a greater anabolic window compared to placebo. • Bone formation markers increased in TPTD- vs. placebo-treated g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d17da27f0e3dad20a1a0cd4a74e9876
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9
Protein timing has no effect on lean mass, strength and functional capacity gains induced by resistance exercise in postmenopausal women: A randomized clinical trial
Autor: Kely R. C. Teixeira, Paula C. Nahas, Erick P. de Oliveira, Fábio Lera Orsatti, Gersiel N. de Oliveira, Luana T. Rossato, Flávia M.S. de Branco, Marcelo A S Carneiro
Publikováno v: Clinical nutrition (Edinburgh, Scotland). 39(1)
Short-term studies have shown that protein intake immediately post-exercise increases muscle protein synthesis. However, the effect of protein timing (comparing protein intake post-exercise vs. several hours after exercise) on lean mass and strength
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed390d7595dd7ce7abda95bb33e28a7
https://pubmed.ncbi.nlm.nih.gov/30691866
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10
Daytime and nighttime casein supplements similarly increase muscle size and strength in response to resistance training earlier in the day: a preliminary investigation
Autor: K Shane Broughton, Jordan M. Joy, Nancy M. DiMarco, Robert Wildman, Roxanne M. Vogel, Urszula Kudla, Jason M. Davison, Nathaniel Y. Kerr
Publikováno v: Journal of the International Society of Sports Nutrition, 15:24
Journal of the International Society of Sports Nutrition
Journal of the International Society of Sports Nutrition, Vol 15, Iss 1, Pp 1-9 (2018)
BACKGROUND: Casein protein consumed before sleep has been suggested to offer an overnight supply of exogenous amino acids for anabolic processes. The purpose of this study was to compare supplemental casein consumed earlier in the day (DayTime, DT) v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d23a1106f0cd817a5053dbdee542d94
https://doi.org/10.1186/s12970-018-0228-9
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