Zobrazeno 1 - 10
of 1 968
pro vyhledávání: '"Metabolic modeling"'
Autor:
Regina Kutscha, Tamara Tomin, Ruth Birner-Gruenberger, Pavlos Stephanos Bekiaris, Steffen Klamt, Stefan Pflügl
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background Due to increasing ecological concerns, microbial production of biochemicals from sustainable carbon sources like acetate is rapidly gaining importance. However, to successfully establish large-scale production scenarios, a solid u
Externí odkaz:
https://doaj.org/article/b9282df3936343e3bad713dfeafaf178
Autor:
Yujiro Hirose, Daniel C. Zielinski, Saugat Poudel, Kevin Rychel, Jonathon L. Baker, Yoshihiro Toya, Masaya Yamaguchi, Almut Heinken, Ines Thiele, Shigetada Kawabata, Bernhard O. Palsson, Victor Nizet
Publikováno v:
mSystems, Vol 9, Iss 9 (2024)
ABSTRACT Streptococcus pyogenes is responsible for a range of diseases in humans contributing significantly to morbidity and mortality. Among more than 200 serotypes of S. pyogenes, serotype M1 strains hold the greatest clinical relevance due to thei
Externí odkaz:
https://doaj.org/article/370f8241006e4225bac7c0888054f2d2
Autor:
Guillem Santamaria, Francisco R. Pinto
Publikováno v:
BioChem, Vol 4, Iss 2, Pp 90-114 (2024)
Metabolites are at the end of the gene–transcript–protein–metabolism cascade. As such, metabolomics is the omics approach that offers the most direct correlation with phenotype. This allows, where genomics, transcriptomics and proteomics fail t
Externí odkaz:
https://doaj.org/article/ab84e9a473ef42d2b778081843b2c3d1
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 1, Pp 33-42 (2024)
Metabolic modeling and machine learning (ML) are crucial components of the evolving next-generation tools in systems and synthetic biology, aiming to unravel the intricate relationship between genotype, phenotype, and the environment. Nonetheless, th
Externí odkaz:
https://doaj.org/article/336fa4e2a8254caf956c0bfea2910a81
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
Mechanistic, constraint-based models of microbial isolates or communities are a staple in the metabolic analysis toolbox, but predictions about microbe-microbe and microbe-environment interactions are only as good as the accuracy of transporter annot
Externí odkaz:
https://doaj.org/article/3d84aa9ed820429e823627cd7de03023
Autor:
Sarah Snanoudj, Céline Derambure, Cheng Zhang, Nguyen Thi Hai Yen, Céline Lesueur, Sophie Coutant, Lénaïg Abily-Donval, Stéphane Marret, Hong Yang, Adil Mardinoglu, Soumeya Bekri, Abdellah Tebani
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34357- (2024)
Fabry disease (FD) is an X-linked lysosomal disease caused by an enzyme deficiency of alpha-galactosidase A (α-gal A). This deficiency leads to the accumulation of glycosphingolipids in lysosomes, resulting in a range of clinical symptoms. The compl
Externí odkaz:
https://doaj.org/article/98f4d6744b8c48ab8fb74841335491bb
Autor:
Leif Tueffers, Aditi Batra, Johannes Zimmermann, João Botelho, Florian Buchholz, Junqi Liao, Nicolás Mendoza Mejía, Antje Munder, Jens Klockgether, Burkhard Tüemmler, Jan Rupp, Hinrich Schulenburg
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT Pseudomonas aeruginosa is a ubiquitous, opportunistic human pathogen. Since it often expresses multidrug resistance, new treatment options are urgently required. Such new treatments are usually assessed with one of the canonical laboratory s
Externí odkaz:
https://doaj.org/article/03e4de67c9534611a14e37d744063dcb
Autor:
Kathleen L. Furtado, Lucas Plott, Matthew Markovetz, Deborah Powers, Hao Wang, David B. Hill, Jason Papin, Nancy L. Allbritton, Rita Tamayo
Publikováno v:
mSphere, Vol 9, Iss 6 (2024)
ABSTRACT In a healthy colon, the stratified mucus layer serves as a crucial innate immune barrier to protect the epithelium from microbes. Mucins are complex glycoproteins that serve as a nutrient source for resident microflora and can be exploited b
Externí odkaz:
https://doaj.org/article/450e725c3eaa4445b01f73bf39855948
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background Microbial communities play a crucial role in ecosystem function through metabolic interactions. Genome-scale modeling is a promising method to understand these interactions and identify strategies to optimize the community. Flux b
Externí odkaz:
https://doaj.org/article/68430eeee1e14322a45f8122119299d7
Autor:
Amandine Paulay, Ghjuvan M. Grimaud, Raphaël Caballero, Béatrice Laroche, Marion Leclerc, Simon Labarthe, Emmanuelle Maguin
Publikováno v:
mSystems, Vol 9, Iss 4 (2024)
ABSTRACTThe gut microbiota plays a crucial role in health and is significantly modulated by human diets. In addition to Western diets which are rich in proteins, high-protein diets are used for specific populations or indications, mainly weight loss.
Externí odkaz:
https://doaj.org/article/9aa081b3c8f344dc8831437e91f127cb