Zobrazeno 1 - 10
of 916
pro vyhledávání: '"Metabolic memory"'
Autor:
Farhana Begum, Karpagavel Lakshmanan
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Diabetes mellitus and its complications exploit significantly impact global human well-being and economic burden. Previous studies and clinical trials have provided insights into the concept of metabolic memory, which sustains even after hyp
Externí odkaz:
https://doaj.org/article/8e4a6a0d46f44540912e6252eab2fe2d
Publikováno v:
International Journal of Ophthalmology, Vol 17, Iss 7, Pp 1232-1237 (2024)
AIM: To examine the regulatory role of microRNA-204 (miR-204) on silent information regulator 1 (SIRT1) and vascular endothelial growth factor (VEGF) under high-glucose-induced metabolic memory in human retinal pigment epithelial (hRPE) cells. METHOD
Externí odkaz:
https://doaj.org/article/da8879b586f0455bb0a3e7d36d80e3e1
Autor:
Tongyue Yang, Feng Qi, Feng Guo, Mingwei Shao, Yi Song, Gaofei Ren, Zhao Linlin, Guijun Qin, Yanyan Zhao
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-19 (2024)
Abstract Diabetes mellitus, a chronic metabolic disease, often leads to numerous chronic complications, significantly contributing to global morbidity and mortality rates. High glucose levels trigger epigenetic modifications linked to pathophysiologi
Externí odkaz:
https://doaj.org/article/70b34ffdc77e46258ed1e820b68920c7
Publikováno v:
Journal of Diabetes, Vol 16, Iss 11, Pp n/a-n/a (2024)
Abstract Progression of diabetic retinopathy resists arrest even after institution of intensive glycemic control, suggesting a “metabolic memory” phenomenon, but the mechanism responsible for this phenomenon is still elusive. Gene expression and
Externí odkaz:
https://doaj.org/article/3daecec8dc704d7981bcb70fcc89f477
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundGlomerular fibrosis is a tissue damage that occurs within the kidneys of chronic and diabetic kidney disease patients. Effective treatments are lacking, and the mechanism of glomerular damage reversal is poorly understood.MethodsA mathemati
Externí odkaz:
https://doaj.org/article/dcda3b9867c5435ca3ceeaf68f56d014
Autor:
Abhishek Sheemar, Keerthi Bellala, Sumant Vinayak Sharma, Sarmeela Sharma, Inderjeet Kaur, Padmaja Rani, Sobha Sivaprasad, KM Venkat Narayan, Taraprasad Das, Brijesh Takkar
Publikováno v:
Indian Journal of Ophthalmology, Vol 72, Iss 6, Pp 796-808 (2024)
The response of retinal pathology to interventions in diabetic retinopathy (DR) is often independent of the glycated hemoglobin (HbA1c) values at the point of care. This is despite glucose control being one of the strongest risk factors for the devel
Externí odkaz:
https://doaj.org/article/594280c220c1457a9b5f9db54f693e73
Publikováno v:
Animal, Vol 18, Iss 9, Pp 101261- (2024)
Grazing management significantly contributes to low beef production in cow-calf systems within the Rio de la Plata native grasslands. An herbage allowance (HA) of 4 kg DM/kg BW increased the productive response of primiparous cows grazing shallow soi
Externí odkaz:
https://doaj.org/article/11a34f475a6046d4b89dc321bd657d54
Autor:
Tongyue Yang, Qi Feng, Mingwei Shao, Mengxing Pan, Feng Guo, Yi Song, Fengjuan Huang, Zhao Linlin, Jiao Wang, Lina Wu, Guijun Qin, Yanyan Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Diabetic kidney disease (DKD) is characterized by complex pathogenesis and poor prognosis; therefore, an exploration of novel etiological factors may be beneficial. Despite glycemic control, the persistence of transient hyperglycemia still induces va
Externí odkaz:
https://doaj.org/article/7ca61470a6764da0859fd66d9516d88b
Autor:
Anatoly I. Bozhkov, Nataliia I. Dobrianska, Rustam A. Akzhyhitov, Anna V. Novikova, Stanislav S. Haiovyi, Alona O. Pankratova, Olena O. Ivanova, Illia R. Onipko, Yuliia O. Komburlei
Publikováno v:
Translational Medicine of Aging, Vol 8, Iss , Pp 1-11 (2024)
The study of the young and old animals’ adaptation characteristics to the chronic effect of ethyl alcohol provides a quick solution of problems in biomedicine and gerontology, such as the formation of age related dependencies on pathologies. We stu
Externí odkaz:
https://doaj.org/article/9b61a02c2fbd45df80ed2fcee6531fbc
Autor:
Valeria Pellegrini, Rosalba La Grotta, Francesca Carreras, Angelica Giuliani, Jacopo Sabbatinelli, Fabiola Olivieri, Cesare Celeste Berra, Antonio Ceriello, Francesco Prattichizzo
Publikováno v:
Cells, Vol 13, Iss 19, p 1662 (2024)
Low-grade inflammation (LGI) represents a key driver of type 2 diabetes (T2D) and its associated cardiovascular diseases (CVDs). Indeed, inflammatory markers such as hs-CRP and IL-6 predict the development of T2D and its complications, suggesting tha
Externí odkaz:
https://doaj.org/article/5be04407d8f54fb0a87a1c6fcc8823be