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pro vyhledávání: '"Metabolic Control Theory"'
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Akademický článek
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Autor:
Wright, Kevin Matthew
The problem is two fold: how does natural selection operate on systems of interacting genes and how does natural selection operate in natural populations. To address the first problem, I have conducted a theoretical investigation into the evolution o
Externí odkaz:
http://hdl.handle.net/10161/2475
Akademický článek
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Publikováno v:
Annual Plant Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7468967d6708c03a53e966796d54d958
https://doi.org/10.1002/9781119312994.apr0024
https://doi.org/10.1002/9781119312994.apr0024
Publikováno v:
Molecular Biology and Evolution
Molecular Biology and Evolution, 30(8), 1779-1787
Molecular Biology and Evolution 30 (2013) 8
Molecular Biology and Evolution, 30(8), 1779-1787
Molecular Biology and Evolution 30 (2013) 8
Understanding epistasis is central to biology. For instance, epistatic interactions determine the topography of the fitness landscape and affect the dynamics and determinism of adaptation. However, few empirical data are available, and comparing resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b3a112d8b5db418cf543f3027eeca2
http://europepmc.org/articles/PMC3708503
http://europepmc.org/articles/PMC3708503
Autor:
Marta L. Wayne, David W. Hall
Publikováno v:
Genome Biology and Evolution
We explore the evolutionary origins of dosage compensation (DC) in sex chromosomes in the context of metabolic control theory. We consider first the cost of gene loss (hemizygosity) per se in reducing flux, and examine two relationships between flux
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee26b6408ef5c1ac6fc37221dc1826bf
https://doi.org/10.1093/gbe/evs106
https://doi.org/10.1093/gbe/evs106
Autor:
Mark D. Rausher
Publikováno v:
Evolution. 67:34-48
Simulation models of the evolution of genes in a branched metabolic pathway subject to stabilizing selection on flux are described and analyzed. The models are based either on metabolic control theory (MCT), with the assumption that enzymes are far f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::201d3914c1ea211d9cea30bbef96d577
https://doi.org/10.1111/j.1558-5646.2012.01771.x
https://doi.org/10.1111/j.1558-5646.2012.01771.x
Autor:
John P. Blass
Publikováno v:
Annals of the New York Academy of Sciences. 1147:122-128
It is rational to try to normalize changes that correlate with the severity of the clinical disabilities in Alzheimer's disease (AD) rather than focusing on other of the many abnormalities in end-stage AD brain that relate only theoretically to the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6801543d9872cbb671093880b6b0f77d
https://doi.org/10.1196/annals.1427.022
https://doi.org/10.1196/annals.1427.022
Autor:
Reinhard Bürger, O. Mayo
Publikováno v:
Biological Reviews. 72:97-110
The evolution of dominance by the selection of modifiers of the phenotypes of deleterious mutations was proposed as a hypothesis by R. A. Fisher in 1928. It has been strongly criticized ever since, is regarded by many as having been made irrelevant b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1533c380ee8cdd713b4d58bb6f5c2cdc
https://doi.org/10.1111/j.1469-185x.1997.tb00011.x
https://doi.org/10.1111/j.1469-185x.1997.tb00011.x