Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes

Autor: Rotroff, Daniel M, Yee, Sook Wah, Zhou, Kaixin, Marvel, Skylar W, Shah, Hetal S, Jack, John R, Havener, Tammy M, Hedderson, Monique M, Kubo, Michiaki, Herman, Mark A, Gao, He, Mychaleckyi, Josyf C, McLeod, Howard L, Doria, Alessandro, Giacomini, Kathleen M, Pearson, Ewan R, Wagner, Michael J, Buse, John B, Motsinger-Reif, Alison A, MetGen Investigators, ACCORD/ACCORDion Investigators

Publikováno v: Diabetes, vol 67, iss 7

Metformin is the first-line treatment for type 2 diabetes (T2D). Although widely prescribed, the glucose-lowering mechanism for metformin is incompletely understood. Here, we used a genome-wide association approach in a diverse group of individuals w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::91e559e93be8326dd45cfa553d197c59
https://escholarship.org/uc/item/4dc5x41s

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Autor: Kathleen M. Giacomini, Adriaan Kooy, Coen D.A. Stehouwer, MetGen Investigators, Valdis Pirags, Daniel M. Rotroff, Ivan Tkáč, Huan-Chieh Chien, Michael J. Wagner, Shiro Maeda, Federico Innocenti, Joline W.J. Beulens, Monique M. Hedderson, Eric L. Seiser, Sook Wah Yee, Bruno H. Stricker, Accord Investigators, Jozef Židzik, Leen M 't Hart, Rury R. Holman, Alison A. Motsinger-Reif, Jose C. Florez, Albert Hofman, Mattijs Out, Albert M. Levin, Christopher J. Groves, Michiaki Kubo, Longyang Wu, Catherine E. de Keyser, Ewan R. Pearson, Lisa Logie, Calum Sutherland, Sabina Semiz, Tanja Dujic, John S. Witte, Amanda J. Bennett, Kathleen A. Jablonski, Linda Zaharenko, Nienke van Leeuwen, Ling Chen, Dpp Investigators, Roger Tavendale, Ruth L. Coleman, Amber A. van der Heijden, Colin N. A. Palmer, Janis Klovins, Martin Javorský, Ron H.N. van Schaik, Mark I. McCarthy, L. Keoki Williams, Kaixin Zhou

Publikováno v: Nature Genetics, 48(9), 1055
Nature Genetics, 48(9), 1055-+. Nature Publishing Group
Nature Genetics, 48(9), 1055-1059. Nature Publishing Group
Zhou, K, Yee, S W, Seiser, E L, van Leeuwen, N, Tavendalel, R, Bennett, A J, Groves, C J, Coleman, R L, van der Heijden, A A, Beulens, J W, de Keyser, C E, Zaharenkoll, L, Rotroff', D M, Out, M, Jablonski, K A, Chen, L, Javorsky, M, Zidzik, J, Levin, A M, Williams, L K, Dujic, T, Semiz, S, Kubo, M, Chien, H-C, Maeda, S, Witte, J S, Wu, L, Tkac, I, Kooy, A, van Schaik, R H N, Stehouwer, C D A, Logie, L, Sutherland, C, Klovins, J, Pirags, V, Hofman, A, Stricker, B H, Motsinger-Reif, A A, Wagner, M J, Innocenti, F, Hart, L M, Holman, R R, McCarthy, M I, Hedderson, M M, Palmer, C N A, Florez, J C, Giacomini, K M & Pearson, E R 2016, ' Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin ', Nature Genetics, vol. 48, no. 9, pp. 1055-1059 . https://doi.org/10.1038/ng.3632

Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear(1). Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consistin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d8e457d5e17ebbdb7b48c533893063
https://hdl.handle.net/1887/96245